Nimesulide Tablet 100mg

The best prescribed Nimesulide tablet is used for the treatment of acute pain, Primary dysmennorhea and also to treat degenerative joint disease.

Forms: A variety of Nimesulide forms are available in the market like in the form of tablets and syrup for oral administration and gels for topical application.

Nimesulide 100mg Therapeutic indications:

• Treatment of acute pain
• Symptomatic treatment of painful osteoarthritis
• Primary dysmenorrhoea.

Nimesulide 100mg Tablets/granules should be used for the shortest possible duration, as required by the clinical situation.

Absorption:
Well absorbed from GI tract following oral admin. Peak plasma levels:1-3 hours. With bid admin of 100 mg, steady-state is achieved within 24-36 hours.

Nimesulide 100mg Uses:

• Analgesic and antipyretic.
• Rheumatoid arthritis, osteoarthritis, other degenerative joint disorders.
• Musculo skeletal disorders.
• Thrombophlebitis.

Nimesulide is commercially available in Europe as tablets (100 mg), granules for oral suspension (100 mg), suppositories (200 mg) and gel (3%).

Nimesulide BP

Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory pain killer drug(NSAID) prescribed for treatment of acute pain, Primary dysmennorhea and degenerative joint disease.

This medicine has potent analgesic, anti pyretic and anti-inflammatory activity on oral & rectal administration.

Nimesulide BP 100mg prevents the release of prostaglandins which is responsible for inflammation, pain & fever.

Nimesulide is a selective inhibitor of prostaglandin synthesis but appears to exert its therapeutic effect by a variety of other mechanisms like inhibition of platelet-activating factor (PAF), tumour necrosis factor-alpha (TNF alpha,) Proteinase & histamine etc.

Nimesulide is Indicated in reducing pain, fever and inflammatory symptoms of:

• Chronic arthritis
• Osteo arthritis
• Otorhinolary diseases
• Soft tissues and oral cavity inflammation
• Dysmenorrhoea
• Thrombosis
• Urogenital disease
• Postoperative pain states
• Sports injuries

Nimesulide Drugbank

Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties which, preferentially inhibits the enzyme cyclooxygenase-2 (COX-2) and has better gastro-intestinal tolerability among other NSAIDs in its class

Its approved indications are the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea, sports injuries etc.

It is used for treatment of all types of pains resulting from sports injury, depression etc.

Nimesulide dose should be taken by prescription of physician and doctor which will help to take proper dose for good result.

Pharmacology: Food, gender and advanced age have negligible effects on Nimesulide pharmacokinetics.

Brands:

Nimesulide is accessible in worldwide among 50 nations with different brands like Sulide, Nimalox, Nimesil, Nimulid, Nicip, Nimcap, Nise, Sulidene and Zolan.

Nimesulide Tablet Efiicacy

The abilities of NSAID’s drug Nimesulide to inhibit COX-2 preferentially and to exert other novel anti-inflammatory actions are consistent with good efficacy and safety with highly effective in reducing pain, inflammation and also helps in better penetration of the antibiotics.

Nimesulide posses analgesic properties with multifactorial mode of action for the treatment of musculoskeletal system, dysmenorrhoea, and acute pain.

It also undergoes extensive biotransformation. The recent study on the basis of analgesic activity of Nimesulide has proved that it has a quicker onset which shows relief from pain relief and inflammation within 15 minutes from drug intake.

Nimesulide is recommended for the shortest duration necessary to control symptoms in patients with acute pain or primary dysmenorrhoea.

Nimesulide Analgesic action and Antipyretic properties

Nimesulide drug for pain relief has a relatively rapid onset of the analgesic action for the patients suffering from acute pain which shows meaningful reductions observed within 15 minutes from drug intake.

Nimesulide is a prescription-only drug and must be prescribed by a licensed physician after careful evaluation of the patient’s characteristics and needs.

As per the recent evaluations on the safety profile of nimesulide confirms that nimesulide has a favourable benefit/risk profile in the approved indications.

Nimesulide shows multifactorial mode of action for the treatment of for post-traumatic inflammation, acute musculoskeletal disorders including sprains, strains, tendinitis, tenosynovitis, low back pain, periarthritis (shoulder pain) and osteoarthritis (joint pains), stiffness.

Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.

Nimesulide tablet has great analgesic and antipyretic properties which is nothing but relief from pain and reduction of body temperature.

The overall safety profile of nimesulide is in line with that of all other NSAIDs. As with all drugs, it must be used in the most appropriate way to guarantee its best therapeutic value.

As for other NSAIDs the use of Nimesulide is preffered for the shortest duration necessary to control symptoms in patients with acute pain or primary dysmenorrhoea. The efficacy of Nimesulide was consistently superior to placebo with its particularly rapid onset action.

Nimesulide Drug Synthesis

Nimesulide is a non-steroidal anti-inflammatory agent that is generally utilized as a part of the treatment of inflammatory torment which hinders the protein cyclooxygenase-2 (COX-2) and has better gastro-intestinal mediocrity in addition to different NSAIDs in its class.

Its approved signs are the treatment of intense torment, the symptomatic treatment of osteoarthritis and essential dysmenorrhoea, sports wounds and so on.

A variety of new Nimesulide derivatives were synthesized through incorporation of a 5-LOX pharmacophore into nimesulide followed with some structural modifications, which were then characterized for dual enzyme inhibitors for these two types of enzymes (Cyclooxygenase-½ (COX-½) and 5-lipoxygenase (5-LOX) ). Their structure-activity relationships (SARs) were studied, and compound 20f was found to be an excellent dual enzyme inhibitor.

Its binding conformation and interaction mode were studied with molecular docking experiments. Compound 20f could become a lead compound for further development for potential anti-inflammatory drugs.

Clinically it has demonstrated that it supports an especially good profile as far as gastrointestinal tolerability.

Nimesulide Medicine for Joint pain treatment

Joint ache influenced by osteoarthritis (OA) which is a gathering of mechanical abnormailities including debasement of joints, and NSAID’s – Nimesulide is most regularly used to treat agony connected with OA.

The primary symptom is agony, creating loss of capacity and regularly solidness. Osteoarthritis (OA) is brought about by aging joints, damage, and obesity. OA usually influences the hands, feet, spine, and the expansive weight bearing joints, for example, the hips and knees.


Nimesulide proved to be significantly more viable in giving symptomatic relief. Nimesulide speaks to a successful operator for the treatment of joint ache, with specific reference to the quick onset of its pain relieving impact.

It additionally utilized for the treatment of primary Dysmenorrhea, and Acute ache.

Nimesulide shows significant diminishments in pain and irritation observed in 15 minutes with pain relieving and antipyretic properties.