Nimesulide Paracetamol Tablets

The effectivity and tolerability of Nimesulide were compared with those of paracetamol in an exceedingly non blind randomized study that recruited 110 kids (64 males, 46 females; aged 3 to 6 years) with inflammation of the higher tract and fever.

Nimesulide suspension (1.5 mg/kg three times daily) or paracetamol sirup (10 mg/kg four times daily) were administered orally till fever resolved. blood heat was recorded and native pain and general discomfort assessed.

Pharmacodynamic

Nimesulide – is an inhibitor of cyclooxygenase so it inhibits synthesis of destructive prostaglandins and spares cytoprotective prostaglandins. Nimesulide appears to exert its effects also through a variety of other mechanisms and involves interference with the production action of mediators other than prostaglandins such as enzymes, toxic oxygen derivatives, cytokines, platelet activating factor and histamine.

Paracetamol – is a valuable central analgesic but weak peripheral anti-inflammatory agent and exhibits agent and exhibits antipyretic action.

Nimesulide was as effective as paracetamol in reducing fever, local pain, and general discomfort. Nimesulide therefore appears to be a minimum of as effective as paracetamol in terms of antipyretic and anti inflammatory activity in children with inflammation of the upper tract and fever.

The other recent study with the patients aged between twelve and sixty years on the premise of analgesic effectiveness and tolerability has well-tried that the analgesic results of Nimesulide had a faster onset (<15 minutes) and was stronger (based on patient opinion). And were well tolerated.

Nimesulide is suggested for the shortest length necessary to regulate symptoms in patients with acute pain or primary dysmenorrhoea.

Nimesulide Tablet Forms

The best prescribed Nimesulide tablet is used for the treatment of acute pain, Primary dysmennorhea and also to treat degenerative joint disease.

Forms: A variety of Nimesulide forms are available in the market like in the form of tablets and syrup for oral administration and gels for topical application.

Dose: Nimesulide is available with the dosage of 100 mg for tablets, 100 mg for granules for oral suspension, 200mg for suppositories and 3% of gel.

Nimesulide tablets exerts less gastrointestinal adverse effects than other NSAIDs. It is available in different brands in worldwide among 50 countries.

Nimesulide is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF).

Nimesulide transdermal gel is a well tolerated novel hydroalcoholic microcarrier based drug delivery system with penetration enhancer, indicated for a variety of conditions characterized by pain, inflammation and stiffness, such as osteoarthritis, periarthritis, post-traumatic or acute musculoskeletal disorders including tendinitis, tenosynovitis, sprains, strains and low back pain.

Solubility of Nimesulide was studied using different cosolvent mixtures and various classes of non-ionic surfactant. Solubility increased drastically (>70 mg/rnl) when polyethylene glycol 300 and polyethylene glycol 400 were used as solvents.

The quick dissolving tablets of Nimesulide contains superdisintegrants, that accelerates the disintegration of tablets by virtue of their ability to soak up great deal of water once exposed to binary compound surroundings.

Nimesulide for the Treatment of Dengue.

Nimesulide is prescribed for the treatment of Dengue. Dengue i s the most rapidly spreading mosquito-borne viral disease in the world it is an acute febrile viral disease frequently presenting with headaches, bone or joint and muscular pains, rash and leukopenia as symptoms.

Nimesulide is COX-2 selective non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties, used because of less gastrointestinal side effects compared to other non-selective NSAIDs absorbed rapidly and completely after administration.

Nimesulide is available with the dosage of 100 mg for tablets, 100 mg for granules for oral suspension, 200mg for suppositories and 3% of gel.

Nimesulide Tablet is used for: 

• Rapid onset of action within 15 minutes
• Nimesulide has less gastrointestinal adverse effects than other NSAIDs.
• Its multifactorial mode of action gives it a unique and broad action on inflammatory.
• Nimesulide is also safe in sensitive asthmatic patients. It is reported to be beneficial in relieving the symptoms

Nimesulide Drug Interactions

Nimesulide is analgesic, antipyretic and anti-inflammatory agent that differs from conventional nonsteroidal anti-inflammatory drugs both in structure and pharmacological profile.

It inhibits prostaglandin synthetase/cyclooxygenase, which limits prostaglandin production. Its cyclooxygenase inhibiting potency is intermediate, but is relatively selective for the cyclo-oxygenase-2 (COX-2) thus the potential for gastric injury and intolerance is less. It is also a free radical scavenger, and helps protect against the tissue damage that occurs during inflammation.

It is Well absorbed from GI tract following oral admin. Peak plasma levels:1-3 hours. With bid admin of 100 mg, steady-state is achieved within 24-36 hours.

Therapeutic Categories

• Analgesic, antipyretic and anti-inflammatory agent
• Non-steroidal anti-inflammatory drug, NSAID

It behaves as a competetive inhibitor of histamine release in-vivo and in-vitro, hence posseses antihistaminic and antiallergic properties.

Nimesulide Combination

The generic Nimesulide combination is manufactured by 399 companies and has nearly 522 Brands of Generics of Nimesulide.

Nimesulide is a Non steroidal anti inflammatory drug (NSAID) and targets COX-2 an enzyme responsible for inflammation & pain.

The Nimesulide is preferably used in the composition in an amount of 0.1-5% by weight, more preferably in an amount of 0.1-3% by weight, most preferably in an amount of around 1 % by weight of the composition.

Some of brands of Nimesulide are:

• Nepar - Nimuselide 100 mg + Paracetamol 500 mg
• Nimular Plus - Nimesulide, Acetaminophen
• Nipar (100 mg) - Nimesulide, Paracetamol
• Abinim-P - Nimesulide 100 mg, paracetamol 500 mg.

Nimesulide is distributed world-wide through a network of selected international partners. 

Nimesulide is mainly used for the treatment of:

• Back Pain 
• Dysmenorrhea
• Osteoarthritis
• Rheumatoid Arthritis

Nimesulide is always recommended to use under a licensed physician supervision

Nimesulide Gel System for Topical Use

Nimesulide is a known Anti inflamatory agent whose therapeutical efficacy has been proved for acute Acute pain relief and Primary dysmennorhea and and also to treat degenerative joint disease

Nimesulide is available in various forms like Gel, Powder, etc. Nimesulide Gel is used to treat chronic and acute musculoskeletal disorders such as soft tissue injuries or non-articular rheumatic disorders, including discomfort in the muscles, tendonitis, back pain/ache, arthritis, tenosynovitis sprains, or strains. The onset of pain relief was normally observed within 15-60 minutes.

Nimesulide transdermal gel was statistically more significant in reducing the mean scores of pain intensity

Nimesulide is available in assortment of structures like as tablets and syrup for oral organization and gels for topical application.

The anti-inflammatory activity of topically applied Nimesulide gel demonstrations particularly on cyclo-oxygenase-2 which applies less gastrointestinal antagonistic impacts than different NSAIDs.

Nimesulide Solubility in Organic Solvents

NSAID drug Nimesulide has tried advantages within the treatment of Acute (short term) pain, Painful degenerative arthritis (Swelling within the joints) and first dysmennorhea (Period Pains).

Nimesulide is out there in varied forms like Nimesulide Tablets, Nimesulide Powder, Nimesulide Gel, suppositories etc.

Nimesulide is soluble in organic solvents like fermentation alcohol, DMSO, and dimethyl formamide (DMF).

Nimesulide is a good and safe therapeutic selection for the treatment of assorted painful inflammatory conditions, with a speedy onset of analgesic activity.

The prescription of a drug is suitable once the profit it’s able to give to a selected patient outweigh the risks related to its use. A careful analysis of individual risk factors is thus of crucial importance.

As for different NSAIDs the utilization of Nimesulide is suggested for the shortest length necessary to regulate symptoms in patients with acute pain or primary dysmenorrhoea.