Friday, November 27, 2015

Nimesulide Tablet Uses

Nimesulide Tablet Uses

Nimesulide medication is a non-steroidal anti-inflammatory drug with analgesic and antyperetic properties, prescribed for painful inflammatory conditions, back pain, dysmenorrhea and etc.

The usual dosage of Nimesulide is 100mg twice a day. For children it should be taken 5mg/kg of body weight in 2 or 3 divided doses

Nimesulide is used to reduce:
  1. Osteoarthritis
  2. Low back Pain
  3. Sports injury
  4. Dental pain
  5. Moderate pain & fever
  6. Dysmenorrhea
Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.

Nimesulide is reported to be beneficial in relieving the symptoms of rhinitis, rhinopharyngitis tubaritis and seceretory otitis media with concomitant antibiotic treatment.

Thursday, November 26, 2015

Nimesulide drug interactions


Nimesulide is a prescribed analgesic, antipyretic and anti-inflammatory agent that differs from conventional nonsteroidal anti-inflammatory drugs both in structure and pharmacological profile.

Its approved indications are the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults.

it’s an ethical medicine suggested to use medicine beneath authorised physician supervision.

Nimesulide is a recently developed analgesic, antipyretic and anti-inflammatory agent that differs from conventional nonsteroidal anti-inflammatory drugs both in structure and pharmacological profile. Since nimesulide may be prescribed for patients receiving concomitant medication, the propensity for drug interactions exists.
Nimesulide is also available in the form of dissolving tablets, granules for oral suspension, and Gel. The fast dissolving tablets of Nimesulide contains superdisintegrants, which accelerates the disintegration of tablets by virtue of their ability to absorb large amount of water when exposed to aqueous Environment.
Major interactions involving interference with drug metabolism have not been described with Nimesulide.
A marginal decrease in plasma theophylline levels (without changes in respiratory function tests) has been described after addition of Nimesulide to chronic theophylline therapy. Nimesulide is available in the market with the dosage of 100Mg.


Nimesulide composition

Nimesulide is a non-steroidal anti-inflammatory agent that is widely used in the treatment of inflammatory pain.The efficacy and tolerability of nimesulide was consistently superior to placebo.

Nimesulide tablet undergoes extensive biotransformation and has a relatively rapid onset of action, with meaningful reductions in pain and inflammation observed within 15 minutes from drug intake.

The drug belongs to the class II of Biopharmaceutical Classification System (low solubility, high permeability) and therefore, absorption of this drug is limited by its dissolution.

 Nimesulide is a Non steroidal anti inflammatory drug (NSAID) and targets COX-2 an enzyme responsible for inflammation & pain.

The nimesulide is preferably used in the composition in an amount of 0.1-5% by weight, more preferably in an amount of 0.1-3% by weight, most preferably in an amount of around 1 % by weight of the composition.
This medication is for the most part used as an issue of the treatment of inflammatory torment and also used for postoperative trauma, sports injuries, acute musculoskeletal disorders.
Uses of Nimesulide:
  • Rapid onset of action within 15 minutes
  • Rapidly relieves pain in arthritis
The nimesulide is preferably used in the composition in an amount of 0.1-5% by weight, more preferably in an amount of 0.1-3% by weight, most preferably in an amount of around 1 % by weight of the composition.
This medication is for the most part used as an issue of the treatment of inflammatory torment and also used for postoperative trauma, sports injuries, acute musculoskeletal disorders

Nimesulide Structure

Nimesulide Structure

Nimesulide is generally utilized as a part of the treatment of inflammatory torment which hinders the protein cyclooxygenase-2 (COX-2) and has better gastro-intestinal mediocrity in addition to different NSAIDs in its class.

Nimesulide (4-nitro-2-phenoxymethanesulfoanilide) This compound, a by-product of p-nitrophenyl methane series sulfa, is structurally a singular non-steroidal anti-inflammatory drug.

It is available in more than 50 countries worldwide.


Features:
  • Amongst most effective yet gastro friendly
  • Non steroidal anti inflammatory drug (NSAID)
  • Nimesulide targets COX-2 an enzyme responsible for inflammation & pain.

Uses of Nimesulide:
  1. Nimesulide tablet has excellent gastrointestinal safety in comparison to other medication.
  2. Rapid onset of action within 15 minutes
  3. Rapidly relieves pain in arthritis

Ninesulide Tablet uses

Nimesulide Tablet Uses

Nimesulide medication is a non-steroidal anti-inflammatory drug with analgesic and antyperetic properties, prescribed for painful inflammatory conditions, back pain, dysmenorrhea and etc.

The usual dosage of Nimesulide is 100mg twice a day. For children it should be taken 5mg/kg of body weight in 2 or 3 divided doses

Nimesulide is used to reduce:
  1. Osteoarthritis
  2. Low back Pain
  3. Sports injury
  4. Dental pain
  5. Moderate pain & fever
  6. Dysmenorrhea
Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.

Nimesulide is reported to be beneficial in relieving the symptoms of rhinitis, rhinopharyngitis tubaritis and seceretory otitis media with concomitant antibiotic treatment.

Precautions:

Women should use the drug with caution during lactation; Nimesulide is contraindicated during pregnancy.

Nimesulide for instant pain relief

Pain relief drug nimesulide which shows the instant pain relief from acute pain (short-term pain)within 15 minitues of drug intake

Nimesulide is a prescription-only drug and must be prescribed by a licensed physician after careful evaluation of the patient’s characteristics and needs.
Clinical studies have been carried out in a wide variety of acute inflammatory and painful conditions with the aim of evaluating the analgesic activity of nimesulide in comparison to placebo and to some of the most common NSAIDs.
In these studies, it is observed that the efficacy of nimesulide was consistently superior to placebo with a particularly fast onset of the analgesic in action.

The rapid action shows the immediate relief within the 15 min from the drug intake for the acute pain.

It must be used under supervision by a doctor in accordance with the approved indications and in compliance with the recommendations .The overall safety profile of nimesulide is in line with that of all other NSAIDs. As with all drugs, it must be used in the most appropriate way to guarantee its best therapeutic value.

Nimesulide Tablet Dose

Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) with analgesic (painrelief) and antipyretic(fever-reducing) effects.
Indications:
Nimesulide is mostly used for treatment of short-term pain(Acute), joint pain (osteoarthritis), period pains (Primary dysmennorhea), Chronic pains (long-term) and many.
Nimesulide Dosage:
  • Adults: 100 mg twice daily
  • Children: 5mg/kg of body weight in 2 or 3 divided doses.
  • Oral
    Dysmenorrhoea
    Adult: 100 mg bid limited to a max of 15 days.
  • Oral
    Osteoarthritis
    Adult: 100 mg bid limited to a max of 15 days.
  • Oral
    Postoperative pain
    Adult: 100 mg bid limited to a max of 15 days.
  • Oral
    Acute pain
    Adult: 100 mg bid limited to a max of 15 days.
The maximum duration and dose of a treatment course with Nimesulide is 15 days, 100 mg twice a day, to minimize the risk of hepatotoxicity.

Uses of Nimesulide:
  • Rapid onset of action within 15 minutes
  • Rapidly relieves pain in arthritis(joints).
  • Nimesulide has superior gastrointestinal safety as compared to other NSAIDs.
  • Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.
The onset of action of nimesulide is faster and also has a potent and long lasting anti-pyretic affect.