Nimesulide Dosage

Nimesulide Dosage

The most prescribed pain killer drug- Nimesulide is been available since 1985 with a multifactorial mode of action.

Nimesulide is indicated for the treatment of acute pain, Painful osteoarthritis (Swelling in the joints) and primary dysmenorrhoea.

The maximum duration and dose of a treatment course with nimesulide is recommended with the shortest period of 15 days, 100 mg twice a day, to minimize the risk of hepatotoxicity.

Nimesulide should only be prescribed as second line treatment. The decision to prescribe nimesulide should be based on assessment of the individual patient.

Nimesulide has superior gastrointestinal safety as compared to other NSAIDs. Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.

Nimesulide also improves the skin tone and to increase in energy levels. Food, gender and advanced age have negligible effects on Nimesulide pharmacokinetics.

Nimesulide Composition

Nimesulide is a Non steroidal anti inflammatory drug (NSAID) and targets COX-2 an enzyme responsible for inflammation & pain.

The Nimesulide is preferably used in the composition in an amount of 0.1-5% by weight, more preferably in an amount of 0.1-3% by weight, most preferably in an amount of around 1 % by weight of the composition.

This medication is for the most part used as an issue of the treatment of inflammatory torment and also used for postoperative trauma, sports injuries, acute musculoskeletal disorders.

Nimesulide have pain relieving and antipyretic properties which, specially restrains the protein cyclooxygenase-2 (COX-2) and has better gastro-intestinal bearableness in addition to different NSAIDs in its class.

Forms: A variety of Nimesulide forms are available in the market like in the form of tablets and syrup for oral administration and gels for topical application.

Dose: Nimesulide is available with the dosage of 100 mg for tablets, 100 mg for granules for oral suspension, 200mg for suppositories and 3% of gel.

Nimesulide tablet for Primary dysmennorhea

The most powerfull painkiller NSAIDs tablet Nimesulide is used for treating acute (short-term) pain, painful osteoarthritis (swelling in the joints), and Primary dysmennorhea (Period Pains).

Nimesulide is available in the form of tablets (100 mg), granules for oral suspension (100 mg), suppositories (200 mg) and gel (3%).

The maximum duration and dose of a treatment course with nimesulide is 15 days, 100 mg twice a day, to minimize the risk of hepatotoxicity.

Clinical studies have been carried out in a wide variety of acute inflammatory and painful conditions with the aim of evaluating the analgesic activity of nimesulide in comparison to placebo and to some of the most common NSAIDs.In these studies, it is observed that the efficacy of nimesulide was consistently superior to placebo with a particularly fast onset of the analgesic in action.The rapid action shows the immediate relief within the 15 min from the drug intake for the acute pain.

Continuous use of NImesulide may cause certain side effects like Diarrhea, vomiting, skin rash etc., It also preffered to use for the age above 12. Women should use the drug with caution during lactation and it is contraindicated during pregnancy.

Nimesulide Tablet and its Antipyretic Properties

Nimesulide is a nonsteroidal arylsulfonamide with anti-inflammatory properties.

Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties.

Nimesulide shows multifactorial mode of action for the treatment of for post-traumatic inflammation, acute musculoskeletal disorders including sprains, strains, tendinitis, tenosynovitis, low back pain, periarthritis (shoulder pain) and osteoarthritis (joint pains), stiffness.

The drug is developed by Helsinn Healthcare. Medicines containing Nimesulide are on the market since 1985 and are authorised in a number of Member States.

Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.

Nimesulide is available in the form of tablets (100 mg), granules for oral suspension (100 mg), suppositories (200 mg) and gel (3%).

The maximum duration and dose of a treatment course with Nimesulide is 15 days, 100 mg twice a day, to minimize the risk of hepatotoxicity.

Nimesulide Uses

Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) which acts as a cyclooxygenase- 2 inhibitor. It has become a leading NSAID in over 50 countries worldwide.

Nimesulide tablet is used for the treatment of osteoarthritis, postoperative trauma, sports injuries, acute musculoskeletal disorders including tendonitis, tenosynovitis, sprains, strains and low back pain, ear, nose and throat disorders.

Usage of Nimesulide 100mg- Tablet:

• Nimesulide has less gastrointestinal adverse effects than other NSAIDs.
• It has superior benefit-risk ratio to other drugs with a comparable safety and tolerability to placebo.
• Its multifactorial mode of action gives it a unique and broad action on inflammatory.
• Nimesulide is also safe in sensitive asthmatic patients. It is reported to be beneficial in relieving the symptoms of rhinitis, rhinopharyngitis tubaritis and seceretory otitis media with concomitant antibiotic treatment.
• Nimesulide has potent analgesic, anti-inflammatory and antipyretic activities.

Nimesulide tablet undergoes extensive biotransformation and has a relatively rapid onset of action, with meaningful reductions in pain and inflammation observed within 15 minutes from drug intake.

Its an anti-inflammatory with analgesic and antipyretic activity. It is also has low gastro-intestinal and renal toxicity.

Nimesulide Pills

A non-steroidal anti-inflammatory most prescribed drug - Nimesulide that contains dose of 100mg and it’s used for treating acute (short-term) pain, painful osteoarthritis (swelling in the joints), and Primary dysmennorhea (Period Pains).

Nimesuilde is first launched in 1985and currently it’s on the market in worldwide of over 50 countries as orginal product with the trademarks of Nise, Nimopen-MP, Nic-Spas, Nimulid, Nicip, e.t.c.

This trademark also has several products by the brand name of Nimulid, Nise.

Popular NSAID drug Nimesulide is available in various forms including tablets, suppositories, soluble powders, and topical gels. 

Apart from its anti inflammatory it’s also an analgesic and antipyretic in action, and it’s an ethical medicine suggested to use medicine beneath authorised physician supervision. 

The drug is recommended to use for the age above 12 years and women ought to use the drug with caution throughout lactation and it is contraindicated during pregnancy. 

Nimesulide Solubility (Newest posts first) - MedsChat - The People's Medicine Community

Nimesulide Solubility (Newest posts first) - MedsChat - The People's Medicine Community

Comparison of the time to analgesic and anti-inflammatory effect in the treatment of gouty arthritis with Nimesulide and sodium Diclofenac

Objective:

To compare the time to presentation of the analgetic and anti-inflammatory effects of granulated and tablet Nimesulide and sodium Diclofenac since the start of therapy for gouty arthritis (GA).

Methods:

90 males with gout were randomized into 3 equal groups. The patients were of age over 18 years, had acute arthritis for less than 3 weeks, affection of 4 and more joints. For 7 days patients of group 1 received Nimesulide (200 mg/day), those of group 2-Nimesulide(200 mg/day), group 3 - Sodium Diclofenac (150 mg/day). Swelling, articular, pain indices were estimated daily for 7 days.

Results:

Patients of group 1 (Nimesulide) experienced pain relief on min 20; patients of Group 2 (Nimesulide) experienced pain attenuation within the first hour. Pain (at rest and movement) and the indices declined faster in group 1 and 2 compared to group 3. Arthritis was arrested in 24 (80%) patients of group 1, 11 (36%) of group 2 and 4 (13%) of group 3.

Conclusions:

Efficacy of Nimesulide for arrest of an acute gout attack exceeds that of sodium diclofenac.

Effects of Nimesulide Drug were more marked than for celecoxib, with evidence of a faster onset of the analgesic action.

Objective:

One Study was designed to investigate the analgesic effects of nimesulide and celecoxib in patients with knee osteoarthritis (OA).

Methods:

44 Patients, Nimesulide (100 mg twice a day) or Celecoxib (200 mg once a day) for 2 weeks. The intensity of joint pain was assessed with a 100-mm visual analogue scale (VAS).

Results:

Effects of Nimesulide were more marked than for celecoxib, with evidence of a faster onset of the analgesic action.

Both after a single or repeated administration, Nimesulide significantly reduced the synovial fluid concentrations of SP and IL-6. Celecoxib, on the other hand, did not change the concentrations of SP and significantly reduced the levels of IL-6 only on day 14. None of the drugs affected IL-8. Both drugs were generally well tolerated.

Conclisions:

These results provide evidence that Nimesulide Drug is an effective agent for the symptomatic treatment of OA.

Nimesulide and Paracetamol

The efficacy and tolerability of nimesulide 100mg were compared with those of paracetamol in a nonblind randomised study that recruited 110 children (64 males, 46 females; aged 3 to 6 years) with inflammation of the upper respiratory tract and fever. Nimesulide suspension (1.5 mg/kg 3 times daily) or paracetamol syrup (10 mg/kg 4 times daily) were administered orally until fever resolved. Body temperature was recorded and local pain and general discomfort assessed. Three patients treated with nimesulide and 6 patients treated with paracetamol withdrew from the study as a result of adverse events, and 1 paracetamol-treated patient discontinued because of a requirement for therapy with steroids. Nimesulide was as effective as paracetamol in reducing fever, local pain, and general discomfort. Nimesulide therefore appears to be at least as effective as paracetamol in terms of antipyretic and anti-inflammatory activity in children with inflammation of the upper respiratory tract and fever.

Nimesulide Use

Nimesulide Use

Nimesulide 100mg is a non-steroidal anti-inflammatory drug, prescribed for painful inflammatory conditions, back pain, dysmenorrhea, postoperative pain, osteoarthritis, and fever.

Nimesulide 100mg  has superior gastrointestinal safety as compared to other NSAIDs.

Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.

It has proven benefits in the treatment of Acute (short term) pain, Painful osteoarthritis (Swelling in the joints) and Primary dysmennorhea ( Period Pains).

Nimesulide Usage:

Nimesulide must be prescribed by a licensed physician as second line treatment in the approved indications and in compliance with the recommendations expressed in the Summary of Product Characteristics.

Daily dose is 100mg twice-a-day.

The maximum duration of a treatment course is 15 days and, as for other NSAIDs, treatment should be as short as possible. Nimesulide is not indicated in children younger than 12.

Other Precautions : 

 Avoid excess dosage. 

Storage Conditions :

Store it in cool place. 

Nimesulide Solubility

The lipophilicity and solubility profile of nimesulide was investigated over a broad pH range. Lipophilicity was assessed by direct partitioning experiments in the octanol-water system using the shake flask method, as well as by reversed-phase HPLC using methanol as organic modifier with or without addition of n-octanol. In the latter case the extrapolated retention factors logk(w) were considered as lipophilicity indices. The presence of n-octanol in the mobile phase proved to be a crucial factor for the establishment of a logk(w)/pH profile very similar to the logD/pH profile of nimesulide. Solubility was determined by the shake flask method using saturated buffer solutions. Both lipophilicity and solubility--pH profiles of nimesulide showed deviations from the theoretically expected behavior as dictated by the Henderson-Hasselbach equation and the usually recorded difference of 4 log units between the corresponding values of the neutral and ionized species in the case of a weak acid. As a consequence the lipophilicity and solubility profiles were found not to be mirror images of each other. However, the pK(a) value of nimesulide could be accurately calculated using part of both lipophilicity and solubility profiles since deviations affected mostly the values at increased ionization.

Nimesulide Drug

Nimesulide Drug:

Nimesulide Drug is a non-steroidal anti-inflammatory drug, prescribed for painful inflammatory conditions, back pain, dysmenorrhea, postoperative pain, osteoarthritis, and fever.

How it should be taken : It comes as a tablet to take by mouth, with food.

Nimesulide  Adavantages:

Nimesulide has superior gastrointestinal safety as compared to other NSAIDs.Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.It has proven benefits in the treatment of Acute (short term) pain, Painful osteoarthritis (Swelling in the joints) and Primary dysmennorhea ( Period Pains).

Nimesulide  Usage:

Nimesulide drug must be prescribed by a licensed physician as second line treatment in the approved indications and in compliance with the recommendations expressed in the Summary of Product Characteristics.

Daily dose is 100mg twice-a-day.

The maximum duration of a treatment course is 15 days and, as for other NSAIDs, treatment should be as short as possible. Nimesulide is not indicated in children younger than 12.

The overall safety profile of nimesulide is in line with that of all other NSAIDs.

As with all drugs, it must be used in the most appropriate way to guarantee its best therapeutic value.

Other Precautions :  Avoid excess dosage. 

Storage Conditions : Store it in cool place. 

Nimesulide is a Safe Drug

Recent evaluations on the safety profile of nimesulide confirm that nimesulide has a favourable benefit/risk profile in the approved indications.
The overall safety profile of nimesulide is in line with that of all other NSAIDs.
As with all drugs, it must be used in the most appropriate way to guarantee its best therapeutic value.

Recently, the High Court dismissed the prohibition on the pediatric version of Nimesulide. 
Now, all forms of Nimesulide are freely available and used by Doctors in more than 50 countries.
Moreover, it has been evaluated by the European Medical agencies which are
one of the most stringent agencies and has been found safe for use. 
As long as you do not take Nimesulide for more than 15 days, its alright.