Nimesulide Painkiller Drug

Nimesulide is used in giving relief from acute pain associated with rheumatoid arthritis, osteoarthritis and primary dysmenorrhoea in adolescents and adults.

The drug is also an effective antipyretic and used to treat headaches and flu. It is also used in treating inflammatory conditions in humans and pain caused by arthritis or severe injury.

Nimesulide is a popular NSAID and available in various forms including tablets, suppositories, water-soluble powders, and topical gels.

Working of Nimesulide

It acts by inhibiting the release of tumour necrosis factor-alpha, acts as a competitive inhibitor of histamine release and reduces superoxide anion formation

Nimesulide Dosage

Adults: 100 mg twice daily
Children: 5mg/kg of body weight in 2 or 3 divided doses.

Nimesulide Drug Uses

Pharmacokinetic:

Nimesulide has a potent Anti-Inflammatory action.It behaves as a competetive inhibitor of histamine release in-vivo and in-vitro, hence posseses antihistaminic and antiallergic properties.

Indications:

Nimesulide is indicated in painful inflammatory conditions associated with musculoskeletal system, dysmenorrhoea, Thrombophlebitis, dental pain and in ENT inflammation.

Absorption:

Well absorbed from GI tract following oral admin. Peak plasma levels:1-3 hours. With bid admin of 100 mg, steady-state is achieved within 24-36 hours.


Routes of Administration and Dosage:

Oral dosage form in adults :100 mg b.i.d In children : 5 mg/kg/day in 2 or 3 divided doses.

Nimesulide Drug uses:

• Nimesulide has less gastrointestinal adverse effects than other NSAIDs
• It has superior benefit-risk ratio to other drugs with a comparable safety and tolerability to placebo.
• Its multifactorial mode of action gives it a unique and broad action on inflammatory.
• Nimesulide is also safe in sensitive asthmatic patients. It is reported to be beneficial in relieving the symptoms of rhinitis, rhinopharyngitis tubaritis and seceretory otitis media with concomitant antibiotic treatment.
• Nimesulide has potent analgesic, anti-inflammatory and antipyretic activities

Nimesulide Painkiller tablet

A unique Non-steroidal anti inflammatory drug Nimesulide was developed by Helsinn Healthcare and is marketed world-wide around 50 countries. It has proven benefits in the treatment of Acute (short term) pain, Painful osteoarthritis (Swelling in the joints) and Primary dysmennorhea ( Period Pains).

Nimesulide is a prescription anti-inflammatory drug with significant analgesic properties and antipyretic properties. It has superior gastrointestinal safety as compared to other NSAIDs.

Indications:

• Pain relief
• Rheumatoid arthritis
• Osteoarthritis
• Low back pain
• Post operative pain management
• Gynecological surgery: Hysterectomy,
• Dental pain

Nimesulide drug must be prescribed by a physician and doctor and is usually recommended for the age higher than 12 years.

Nimesulide is available with distinctive brands like Sulide, Nimalox, Nimesil, Nimulid, Nicip, Nimcap, Nise, Sulidene and Zolan.