Nimesulide dosage

Nimesulide is a Non steroidal anti inflammatory drug (NSAID) and targets COX-2 an enzyme responsible for inflammation & pain.

The nimesulide is preferably used in the composition in an amount of 0.1-5% by weight, more preferably in an amount of 0.1-3% by weight, most preferably in an amount of around 1 % by weight of the composition.

This medication is for the most part used as an issue of the treatment of inflammatory torment and also used for postoperative trauma, sports injuries, acute musculoskeletal disorders.

Nimesulide have pain relieving and antipyretic properties which, specially restrains the protein cyclooxygenase-2 (COX-2) and has better gastro-intestinal bearableness in addition to different Nsaids in its class.

Dosage:

The usual dose is 100mg twice a day.
Children: 5mg/kg of body weight in 2 or 3 divided doses.

The minimum effective dose should be used for the shortest duration to reduce the undesirable effects.

The maximum duration of a treatment course with Nimesulide is 15 days.

Nimesulide 100mg Tablets/granules should be used for the shortest possible duration, as required by the clinical situation.

Nimesulide drug uses

Nimesulide has a potent Anti-Inflammatory action.It behaves as a competetive inhibitor of histamine release in-vivo and in-vitro, hence posseses antihistaminic and antiallergic properties.

Indications: Nimesulide is indicated in painful inflammatory conditions associated with musculoskeletal system, dysmenorrhoea, Thrombophlebitis, dental pain and in ENT inflammation. Absorption Well absorbed from GI tract following oral admin. Peak plasma levels:1-3 hours. With bid admin of 100 mg, steady-state is achieved within 24-36 hours.

Routes of Administration and Dosage: Oral dosage form in adults :100 mg b.i.d In children : 5 mg/kg/day in 2 or 3 divided doses.

Nimesulide Drug uses: 

• Nimesulide has less gastrointestinal adverse effects than other NSAIDs.
• It has superior benefit-risk ratio to other drugs with a comparable safety and tolerability to placebo.
• Its multifactorial mode of action gives it a unique and broad action on inflammatory.
• Nimesulide is also safe in sensitive asthmatic patients.
• It is reported to be beneficial in relieving the symptoms of rhinitis, rhinopharyngitis tubaritis and seceretory otitis media with concomitant antibiotic treatment.
• Nimesulide has potent analgesic, anti-inflammatory and antipyretic activities.
  

Nimesulide gel

Nimesulide is available in various forms including tablets, suppositories, water-soluble powders, and topical gels.

Original Nimesulide is commercially available as tablets (100 mg), granules for oral suspension (100 mg), suppositories (200 mg) and gel (3%).

Nimesulide gel possesses higher anti-inflammatory activity compared to other gel’s.

Dosage and Administration

Nimesulide Gel is apply to the affected area, rubbing in a thin layer of the gel 2 to 4 times every day. For best results, wash the application area beforehand to clean away any oil, grease, or bacteria, allowing the gel to absorb more easily.

Nimesulide is available in assortment of structures like as tablets and syrup for oral organization and gels for topical application.

The anti-inflammatory activity of topically applied Nimesulide gel demonstrations particularly on cyclo-oxygenase-2 which applies less gastrointestinal antagonistic impacts than different NSAIDs.

The superior analgesic activity of Nimesulide transdermal gel has reported good results in terms of decreasing pain and improved functions in musculoskeletal conditions after topical application.

Nimesulide Tablet Uses

Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) which means it provides analgesic (pain-killing) and antipyretic(fever-reducing) effects. Nimesulide is mostly used for treatment of short-term pain(Acute), joint pain (osteoarthritis), period pains (Primary dysmennorhea), Chronic pains and many.

Acute Pain: starts suddenly and usually feels sharp. Broken bones, burns, or cuts are examples of acute pain. Acute pain lasts just a moment or it may last for weeks or months. Some times it may also lead to Chronic pain (long-term pain).

Ex of Chronic pains:

• Headache
• Low back pain
• Cancer pain
• Arthritis pain
• Pain caused by nerve damage

Nimesulide shows positive reaction in the treatment of several painful situations with an acute inflammatory component including primary dysmenorrhea because of the rapid onset of the analgesic action. which Nimesulide shows meaningful reductions observed within 15 minutes from drug intake.

Osteoarthritis: It is most common in middle-aged and older people, and its symptoms can range from very mild to very severe it mostly affects hands and weight-bearing joints such as Knees, hips, feet and the back, but can affect almost any joint in the body.

Joint pains mostly caused due to Obesity, Injury, Heridity, Joint overuse(Over use of any joint like repeated bending of knees), and most common cause is Age.

Nimesulide ease pain and make it favorable in the treatment of joint diseases. A clinical study has been carried out with patients suffering from join pains. This study has proved efficacy and tolerability in patients.

Primary dysmennorhea: It shows pain in lower abdomen which is very common problem in young women (occurring in the absence of pelvic pathology).

Nimesulide is useful in the treatment of pain associated with primary dysmenorrhea. Nimesulide alleviates pain within 30 min. The drug changes the painful state of uterine contracture to painless cyclic contractions.

Nimesulide advantages

Nimesulide Drug is a non-steroidal anti-inflammatory drug (NSAID) developed by Helsinn Healthcare indicated for the treatment of acute pain and primary dysmenorrhoea.

It has been on the market for more than 25 years and it is estimated that more than 9.18 billion treatment days have been prescribed world-wide so far.

Nimesulide Drug is a prescription-only drug and must be prescribed by a licensed physician after careful evaluation of the patient's characteristics and needs.

Except for the topical gel formulation, it is not available "over the counter".

Nimesulide Advantages

• It has superior gastrointestinal safety as compared to other NSAIDs.
• Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.
• It has proven benefits in the treatment of Acute (short term) pain, Painful osteoarthritis (Swelling in the joints) and Primary dysmennorhea ( Period Pains).

Nimesulide's therapeutic value in effectively and rapidly controlling inflammation and pain is supported by significant clinical evidence.

Clinical studies have been carried out in a wide variety of acute inflammatory and painful conditions with the aim of evaluating the analgesic activity of nimesulide in comparison to placebo and to some of the most common NSAIDs.

The overall safety profile of nimesulide is in line with that of all other NSAIDs.

As with all drugs, it must be used in the most appropriate way to guarantee its best therapeutic value.

Advantages reviewed below.

• To treat acute pain
• To treat osteoarthritis
• To treat primary dysmenorrhoea in adolescents and adults above 12 years old.
• Increasing Energy
• Improving Skin Tone

Nimesulide Drug Usage

It must be prescribed by a licensed physician as second line treatment in the approved indications.

Daily dose is 100mg twice-a-day.

The maximum duration of a treatment course is 15 days and, as for other NSAIDs.

Nimesulide Drug is not indicated in children younger than 12.

The overall safety profile of nimesulide is in line with that of all other NSAIDs.

As with all drugs, Nimesulide Drug must be used in the most appropriate way to guarantee its best therapeutic value.

Nimesulide in treatment of dengue

Nimesulide is prescribed for the treatment of Dengue. Dengue i s the most rapidly spreading mosquito-borne viral disease in the world it is an acute febrile viral disease frequently presenting with headaches, bone or joint and muscular pains, rash and leukopenia as symptoms.

Nimesulide is COX-2 selective non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic propertiesNimesulide is available with the dosage of 100 mg for tablets, 100 mg for granules for oral suspension, 200mg for suppositories and 3% of gel.

Nimesulide Tablet is used for:

• Rapid onset of action within 15 minutes
• Nimesulide has less gastrointestinal adverse effects than other NSAIDs.
• Its multifactorial mode of action gives it a unique and broad action on inflammatory.
• Nimesulide is also safe in sensitive asthmatic patients. It is reported to be beneficial in relieving the symptoms

Nimesulide Formulation

Nimesulide, a widely prescribed anti-inflammatory analgesic drug belongs to BCS class II and exhibit low and variable oral bioavailability.

Nimesulide (4-nitro-2-phenoxymethanesulfoanilide) may be a particular Cox-2 anti-inflammatory medication. This compound, a by-result of p-nitrophenyl methane arrangement sulfa, is structurally a solitary non-steroidal anti-inflammatory drug. It has a place with particular COX-2inhibitors, with an intense pain relieving movement.

its shown as second line treatment for  acute pain, symptomatic treatment of excruciating degenerative joint ailment and first dysmenorrhoea.

Nimesulide tablet incorporates:

• Fast results
• Helpful and supportive
• No feature impacts
• Fast and quick effects

Nimesulide Tablet Advantages:

• Nimesulide has less gastrointestinal adverse effects than other NSAIDs
• It has superior benefit-risk ratio to other drugs with a comparable safety and tolerability to placebo.
• Its multifactorial mode of action gives it a unique and broad action on inflammatory.
• Nimesulide is also safe in sensitive asthmatic patients. It is reported to be beneficial in relieving the symptoms of rhinitis, rhinopharyngitis tubaritis and seceretory otitis media with concomitant antibiotic treatment.
• Nimesulide has potent analgesic, anti-inflammatory and antipyretic activities