Nise pain relief tablet

''Nise'' tablet is a trademark for the drug ''Nimesulide'' which is non-steroidal anti-inflammatory drug (NSAID)
  with analgesic and antipyretic properties.

  It is used for the treatment of acute pain, Primary dysmennorhea and also to treat degenerative joint disease.

 Nimesulide drug was launched in Italy for the first time as Aulin and Mesulid in 1985 and is presently available     in more than 50 countries worldwide with different trademarks such as Nise, Sulide, Nimalox, Nimesil, Nimulid, Nicip, Nimcap, Sulidene, and Zolan etc.

It has superior gastrointestinal safety as compared to other NSAIDs.

Nise tablet also shows rapid analgesic activity which gives reductions for the pain within 15 minutes from drug intake.

It must be used under supervision by a doctor in accordance with the approved indications and in compliance with the recommendations.

 

Nise medicine has the rapid onset of analgesic action which shows the immediate relief within the 15 min from the drug intake for the acute pain.

Nise tablet for rapid onset analgesic action

Nise tablet is a prescribed Non-steroidal anti-inflammatory drug with multifactorial mode of action,characterized by a fast onset of analgesic activity. It’s one of the brand for the Nimesulide medicine.

It’s multifactorial mode of action gives the best results in the treatment of Acute (short term) pain, Painful osteoarthritis (Swelling in the joints) and Primary dysmennorhea ( Period Pains).

Clinical studies have been carried out in a wide variety of acute inflammatory and painful conditions with the aim of evaluating the analgesic activity of Nise.

These studies have proven that efficacy of Nise has a rapid pain relief with in the 15min from drug intake.

Nimesulide is a prescription-only drug and must be prescribed by a licensed physician after careful evaluation of the patient’s characteristics and needs. It is preffered to be used for the shortest duration.

prescribed painkiller drug-nimesulide

The most prescribed anti-inflamatory drug Nimesulide was first developed by Helsinn Healthcare and is marketed world-wide.

NImesulide is available in the form of tablets (100 mg), granules for oral suspension (100 mg), suppositories (200 mg) and gel (3%).

The anti-inflammatory drug mechanism of Nimesulide should only be prescribed as second line treatment. It provides the fast onset of the analgesic action.

The rapid onset of the analgesic action is crucial for the patients with acute pain and also in case of treatment with systemic NSAIDs

The harmonized indications in the EU are acute pain, primary dysmenorrhoea. The dosage of Nimesulide ought to be used is 100 mg twice daily, the duration prescribed is 15 days to minimize the risk of hepatotoxicity.

The drug must be used under supervision by a licensed physician in accordance with the approved indications. Prescription of the Nimesulide must be based on assessment of the patients’ characteristics and needs.

Nimesulide is contraindicated in children below 12 years and in patients suffering from liver problems.

Nimesulide efficay in pain

The abilities of NSAID’s drug nimesulide to inhibit COX-2 preferentially and to exert other novel anti-inflammatory actions are consistent with good efficacy and safety with highly effective in reducing pain, inflammation and also helps in better penetration of the antibiotics.

Nimesulide posses analgesic properties with multifactorial mode of action for the treatment of musculoskeletal system, dysmenorrhoea, and acute pain .

It also undergoes extensive biotransformation. The recent study on the basis of analgesic activity of nimesulide has proved that Nimesulide had a quicker onset which shows relief from pain relief and inflammation within 15 minutes from drug intake.

Nimesulide is recommended for the shortest duration necessary to control symptoms in patients with acute pain or primary dysmenorrhoea.

Nimesulide is available in distinctive brands, for instance, Sulide, Nimalox, Nimesil, Nimulid, Nicip, Nimcap, Nise, Sulidene, Zolan and etc.

Nimesulide tablet for cancer treatment

Cancer, also known as a malignant tumour or malignant neoplasm, is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. Cyclooxygenase-2 (COX-2) inhibitor Nimesulide inhibits the proliferation of various types of cancer cells mainly via COX-2 independent mechanisms, which makes it a good lead compound for anti-cancer drug development.

There are more than 100 types of cancer, including breast cancer, skin cancer, lung cancer, colon cancer, prostate cancer, and lymphoma. Symptoms vary depending on the type.

A series of new nimesulide analogs were synthesized based on the structure–function analysis generated previously. It displayed very potent anti-cancer activity.

significantly suppresses the growth of multiple cancer. By usng Nimesulide the sizes of the colon carcinomas were also decreased.

Pharmacokinetic studies demonstrate the good bioavailability of the compound. A set of non-COX-2 active Nimesulide anti-cancer derivatives were synthesized. It works as a good lead compound for anti-cancer drug development

Nimesulide granules

Nimesulide Granules is non-steroidal anti-inflammatory drugs, indicated for the treatment of juvenile chronic arthritis, postoperative pain, acute pain after trauma and primary dysmenorrhea.

Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties.

Its approved indications are the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old.

Active ingredients: nimodipine. Indication: nimesulide granules is non-steroidal anti-inflammatory drugs, indicated for the treatment of juvenile chronic arthritis, postoperative pain, acute pain after trauma and primary dysmenorrhea.

Packaging: 1g / sack; 6, 8, 10 sacks / pack. Contact us for more information.

usage and consumption: oral, the goods only for adults only, a 50 mg to 100 mg daily twice postprandial taking. In accordance with the severity of the conditions and the needs of the patients can be increased to 0.2g, the second service.

elderly patients of the medication should strictly comply with the provisions of doctors. Doctors can reduce under appropriate in the circumstances listed above dosage.

Nimesulide 100mg Drug Interactions

Nimesulide is a leading NSAID’S drug with anti-inflammatory agent that differs from conventional nonsteroidal anti-inflammatory drugs both in structure and pharmacological profile.

Its main purpose is to treat acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea .

Nimesulide Tablet shows the result from pain within 15min from the drug intake

Nimesulide is available in the from of tablet, capsule and gel with the dosage of 100mg. Nimesulide is preffered for the shortest duration to minimize the risk of hepatotoxicity.

NImesulide tablet has a properties of analgesic (pain relief)and antipyretic (reduction of body temperature) 

Non-steroidal anti-inflammatory drug Nimesulide, prescribed for painful inflammatory conditions, back pain, dysmenorrhea, postoperative pain, osteoarthritis, and fever.

Nimesulide is also indicated in painful inflammatory conditions associated with musculoskeletal system, dysmenorrhoea, Thrombophlebitis, dental pain and in ENT inflammation.

Usage of Nimesulide 100mg- Tablet

• Analgesic and antipyretic.
• Rheumatoid arthritis, osteoarthritis, other degenerative joint disorders.
• Musculo skeletal disorders.
• Thrombophlebitis.

Nimesulide tablet has great analgesic and antipyretic properties which is nothing but relief from pain and reduction of body temperature.

Nimesulide should be used only with the medical prescription . A prescription can be considered appropriate when it is in accordance with the approved indications of a drug in terms of demonstrated efficacy, dosage, and treatment duration.

Nimesulide pill

A non-steroidal anti-inflammatory most prescribed drug – Nimesulide that contains dose of 100mg and it’s used for treating acute (short-term) pain, painful osteoarthritis (swelling in the joints), and Primary dysmennorhea (Period Pains).

Nimesuilde is first launched in 1985and currently it’s on the market in worldwide of over 50 countries as orginal product with the trademarks of Nise, Nimopen-MP, Nic-Spas, Nimulid, Nicip, e.t.c.

Nimesulide is a recently developed analgesic, antipyretic and anti-inflammatory agent that differs from conventional nonsteroidal anti-inflammatory drugs both in structure and pharmacological profile. Since nimesulide may be prescribed for patients receiving concomitant medication, the propensity for drug interactions exists.

This trademark also has several products by the brand name of Nimulid, Nise.

Popular NSAID drug Nimesulide is available in various forms including tablets, suppositories, soluble powders, and topical gels.

Major interactions involving interference with drug metabolism have not been described with Nimesulide.

Nimesulide is a leading NSAID’S srug with analgesic, antipyretic and anti-inflammatory Its main purpose is to treat acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea .

Nimesulide Tablet shows the result from pain within 15min from the drug intake

Nimesulide medicine uses

Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) which acts as a cyclooxygenase- 2 inhibitor. It has become a leading NSAID in over 50 countries worldwide.

Nimesulide tablet is used for the treatment of osteoarthritis, postoperative trauma, sports injuries, acute musculoskeletal disorders including tendonitis, tenosynovitis, sprains, strains and low back pain, ear, nose and throat disorders

Nimesulide a specific Cox-2 anti-inflammatory medication which have been turned out to be fundamentally more suitable in giving symptomatic alleviation for intense agony, symptomatic treatment of horrifying degenerative joint sickness and first dysmenorrhoea.

The European Medicines Agency has finished an review of the security and viability of solutions containing Nimesulide (capsules, tablets, suppositories and powder or granules for oral suspension).

Usage of Nimesulide 100mg- Tablet:

Nimesulide has less gastrointestinal adverse effects than other NSAIDs
It has superior benefit-risk ratio to other drugs with a comparable safety and tolerability to placebo.
Its multifactorial mode of action gives it a unique and broad action on inflammatory.
Nimesulide is also safe in sensitive asthmatic patients. It is reported to be beneficial in relieving the symptoms of rhinitis, rhinopharyngitis tubaritis and seceretory otitis media with concomitant antibiotic treatment.

Nimesulide efficacy

Nimesulide is used for the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea.

The efficacy and tolerability of nimesulide was consistently superior to placebo.

Therapy appropriateness when using nimesulide is of outmost importance to safeguard patient’s health and guarantee the product’s therapeutic value.

As for other NSAIDs the use of nimesulide is recommended for the shortest duration necessary to control symptoms in patients with acute pain or primary dysmenorrhoea.

The abilities of NSAID’s drug Nimesulide to inhibit COX-2 preferentially and to exert other novel anti-inflammatory actions are consistent with good efficacy and safety with highly effective in reducing pain, inflammation and also helps in better penetration of the antibiotics.

Nimesulide posses analgesic properties with multifactorial mode of action for the treatment of musculoskeletal system, dysmenorrhoea, and acute pain.

It also undergoes extensive biotransformation. The recent study on the basis of analgesic activity of Nimesulide has proved that it has a quicker onset which shows relief from pain relief and inflammation within 15 minutes from drug intake.

Nimesulide Medicine

Nimesulide a particular Cox-2 anti-inflammatory medication which have been proved to be significantly more viable in giving symptomatic relief for acute pain, symptomatic treatment of excruciating degenerative joint ailment and first dysmenorrhoea.

The European Medicines Agency has completed a review of the safety and effectiveness of medicines containing Nimesulide (capsules, tablets, suppositories and powder or granules for oral suspension).

It has concluded that Nimesulide has great benefits and shows rapid pain relief in 15 min from the drug intake. It issued a recommendation that it shouldbe used for the shortest duration (<15days)

Nimesulide Medicine is used for

cancer treatment – by inhibiting proliferation of various types of cancer cells mainly via COX-2 independent mechanisms, which makes it a good lead compound for anti-cancer drug development.
Joint pain –  Nimesulide represents an effective agent for the treatment of joint pain, with particular reference to the rapid onset of its analgesic effect.Dry skin/ to improve skin toneFeverAnalgesic and antipyretic.Thrombophlebitis. 

Features:
Desirable resultsHelpful and beneficialNo side effectsFast and quick effects

Desirable resultsHelpful and beneficialNo side effectsFast and quick effects

Nimesulide Solubility

Nimesulide is a unique non- steroidal anti-inflammatory drug that acts specifically on cyclo-oxygenase-2 and does not affect cyclo-oxygenase-1. Hence, it exerts its anti-inflammatory action characteristics of non- steroidal anti-inflammatory drug. Solubility of Nimesulide Increased on solubilization of drug in semi-polar solvents and non-ionic surfactants.

Solubility of Nimesulide was studied using different cosolvent mixtures and various classes of non-ionic surfactant. Solubility increased drastically (>70 mg/rnl) when polyethylene glycol 300 and polyethylene glycol 400 were used as solvents.

The quick dissolving tablets of Nimesulide contains superdisintegrants, that accelerates the disintegration of tablets by virtue of their ability to soak up great deal of water once exposed to binary compound surroundings.

Nimesulide is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, Nimesulide should first be dissolved in ethanol and then diluted with the aqueous buffer of choice. Nimesulide has a solubility of approximately <200 μg/ml in a 10% DMSO in PBS (pH 7.2) solution using this method.

Nimesulide Combination

The generic Nimesulide combination is manufactured by 399 companies and has nearly 522 Brands of Generics of Nimesulide.

Nimesulide is a Non steroidal anti inflammatory drug (NSAID) and targets COX-2 an enzyme responsible for inflammation & pain.

The Nimesulide is preferably used in the composition in an amount of 0.1-5% by weight, more preferably in an amount of 0.1-3% by weight, most preferably in an amount of around 1 % by weight of the composition.

Some of brands of Nimesulide are:

• Nepar – Nimuselide 100 mg + Paracetamol 500 mg
• Nimular Plus – Nimesulide, Acetaminophen
• Nipar (100 mg) – Nimesulide, Paracetamol
• Abinim-P – Nimesulide 100 mg, paracetamol 500 mg.Nimesulide is distributed world-wide through a network of selected international partners.

Nimesulide is mainly used for the treatment of:

• Back Pain
• Dysmenorrhea
• Osteoarthritis
• Rheumatoid Arthritis

Nimesulide is always recommended to use under a licensed physician supervision

Nimesulide drug information

Nimesulide medication developed by Helsinn Healthcare is a non-steroidal anti-inflammatory drug, indicated for painful inflammatory conditions, back pain, dysmenorrhea, postoperative pain, osteoarthritis, and fever. Nimesulide tablets are authorised in a number of Member States. They are only available with a prescription. 

It also used for the treatment of

• Skin Tone
• Heart Disease
• Dry Skin

It posses anti-inflammatory and analgesic properties. it’s an ethical medicine suggested to use medicine beneath authorised physician supervision.

Nimesulide is also available in the form of dissolving tablets, granules for oral suspension, and Gel. The fast dissolving tablets of Nimesulide contains superdisintegrants, which accelerates the disintegration of tablets by virtue of their ability to absorb large amount of water when exposed to aqueous environment.

The Nimesulide Tablets are highly effective in reducing pain, inflammation and also helps in better penetration of the antibiotics.

Nimesulide Analgesic Action

Nimesulide drug for pain relief has a relatively rapid onset of the analgesic action for the patients suffering from acute pain which shows meaningful reductions observed within 15 minutes from drug intake.

Nimesulide is a prescription-only drug and must be prescribed by a licensed physician after careful evaluation of the patient’s characteristics and needs.
As per the recent evaluations on the safety profile of nimesulide confirms that nimesulide has a favourable benefit/risk profile in the approved indications.

Nimesulide shows multifactorial mode of action for the treatment of for post-traumatic inflammation, acute musculoskeletal disorders including sprains, strains, tendinitis, tenosynovitis, low back pain, periarthritis (shoulder pain) and osteoarthritis (joint pains), stiffness.

Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.

Nimesulide tablet has great analgesic and antipyretic properties which is nothing but relief from pain and reduction of body temperature.

The overall safety profile of nimesulide is in line with that of all other NSAIDs. As with all drugs, it must be used in the most appropriate way to guarantee its best therapeutic value.

As for other NSAIDs the use of Nimesulide is preffered for the shortest duration necessary to control symptoms in patients with acute pain or primary dysmenorrhoea. The efficacy of Nimesulide was consistently superior to placebo with its particularly rapid onset action.

Nimesulide Formulation And Features

Nimesulide, a widely prescribed anti-inflammatory analgesic drug belongs to BCS class II and exhibit low and variable oral bioavailability.

Nimesulide (4-nitro-2-phenoxymethanesulfoanilide) is a selective COX-2 NSAID drug. This compound, a derivative of p-nitrophenyl methane sulfonamide, is structurally a unique non-steroidal anti-inflammatorydrug. It belongs to selective COX-2inhibitors, with a potent analgesic activity.

it’s indicated as second line treatment for acute pain, symptomatic treatment of painful osteoarthritis and primary dysmenorrhoea.

It’s also used for the treatment of skintone, Heart diseases and dry skin.

Features include

• Desirable results
• Helpful and beneficial
• No side effects
• Fast and quick effects              
•  Usage of Nimesulide 100mg- Tablet
• Analgesic and antipyretic.
• Rheumatoid arthritis, osteoarthritis, other degenerative joint disorders treatment
• Musculo skeletal disorders treatment
• Thrombophlebitis.
• Improves skintone
• Cancer treatment

Nimesulide patent gel Nimulid for Acute pain

A brand from Nimesulide Transdermal Gel, reffered as a Nimulid Transgel within which the composition contains 10mg of nimsulide in each gram of Nimulid.

 Nimesulide gel preparations for localized topical application are indicated for the treatment of symptomatic relief of pain associated with sprains and acute traumatic tendinitis. 

Nimullid Transgel is indicated for post-traumatic inflammation, acute musculoskeletal disorders including sprains, strains, tendinitis, tenosynovitis, low back pain, periarthritis (shoulder pain) and osteoarthritis (joint pains), stiffness. 

The dose needed to be applied is three to four times per day depending on the dimension of the affected size and response.

 Medicalcare ought to be reviewed after 4 weeks. In addition to medicament activity of Nimulid Transgel is also evaluated for primary skin irritation, eye irritation and photo toxicity in rabbits. 

Nimulid Transgel doesn’t cause allergic manifestation, reddening etc.

Nimesulide Brands

Nimesulide Brands

The most powerfull painkiller NSAIDs tablet Nimesulide is been available since 1985 and authorised in worldwide over 50 countries.

It has superior gastrointestinal safety as compared to other NSAIDs.

It is available in various forms apart from tablets such as in the form of Gell, powder, and suppositories. It’s also available in several trademarks.

Nimesulide brands such as Sulide, Nimalox, Nimesil, Nimulid, Nicip, Nimcap, Nise, Sulidene and Zolan.

Nimulid is also obtaining in the form of gel.

The Nimulid Transgel a brand from Nimesulide Transdermal Gel is indicated for post-traumatic inflammation, acute musculoskeletal disorders including sprains, strains, tendinitis, tenosynovitis, low back pain, periarthritis (shoulder pain) and osteoarthritis (joint pains), stiffness.

NIMESULIDE GEL SYSTEM FOR TOPICAL USE

Nimesulide is a known Antiinflamatory agent whose therapeutical efficacy has been proved. Nimesulide is available in various forms like Gel, Powder, etc.

 Nimesulide Gel is used to treat chronic and acute musculoskeletal disorders such as soft tissue injuries or non-articular rheumatic disorders, including discomfort in the muscles, tendonitis, back pain/ache, arthritis, tenosynovitis sprains, or strains.

 The onset of pain relief was normally observed within 15-60 minutes. 

Nimesulide transdermal gel was statistically more significant in reducing the mean scores of pain intensity

Nimesulide synthesis

Nimesulide is a COX-2 selective drug which has the properties of antiinflammatory and antihistaminic, it also possesses analgesic properties.

Apart for the treatment of acute pain, osteoarthritis and primary dysmenorrhoea. Nimesulide is also being widely used for anticancer and antiviral agents.

A variety of new nimesulide derivatives were synthesized through incorporation of a 5-LOX pharmacophore into Nimesulide followed with some structural modifications. which were then characterized for dual enzyme inhibitors for these two types of enzymes (Cyclooxygenase-½ (COX-½) and 5-lipoxygenase (5-LOX) )

Nimesulide is available in various forms like powder/granules, gel, and suppositories.

Clinically it has proven that it supports a particularly good profile in terms of gastrointestinal tolerability.

Its main purpose is to treat acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea.

As for other NSAIDs the use of Nimesulide preffered for the shortest duration necessary to control symptoms in patients with acute pain or primary dysmenorrhoea. The efficacy of Nimesulide was consistently superior to placebo with its particularly rapid onset action.