Nimesulide tablet for cancer treatment

Cancer, also known as a malignant tumour or malignant neoplasm, is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. Cyclooxygenase-2 (COX-2) inhibitor Nimesulide inhibits the proliferation of various types of cancer cells mainly via COX-2 independent mechanisms, which makes it a good lead compound for anti-cancer drug development.

There are more than 100 types of cancer, including breast cancer, skin cancer, lung cancer, colon cancer, prostate cancer, and lymphoma. Symptoms vary depending on the type.

A series of new nimesulide analogs were synthesized based on the structure–function analysis generated previously. It displayed very potent anti-cancer activity.

significantly suppresses the growth of multiple cancer. By usng Nimesulide the sizes of the colon carcinomas were also decreased.

Pharmacokinetic studies demonstrate the good bioavailability of the compound. A set of non-COX-2 active Nimesulide anti-cancer derivatives were synthesized. It works as a good lead compound for anti-cancer drug development

Nimesulide granules

Nimesulide Granules is non-steroidal anti-inflammatory drugs, indicated for the treatment of juvenile chronic arthritis, postoperative pain, acute pain after trauma and primary dysmenorrhea.

Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties.

Its approved indications are the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old.

Active ingredients: nimodipine. Indication: nimesulide granules is non-steroidal anti-inflammatory drugs, indicated for the treatment of juvenile chronic arthritis, postoperative pain, acute pain after trauma and primary dysmenorrhea.

Packaging: 1g / sack; 6, 8, 10 sacks / pack. Contact us for more information.

usage and consumption: oral, the goods only for adults only, a 50 mg to 100 mg daily twice postprandial taking. In accordance with the severity of the conditions and the needs of the patients can be increased to 0.2g, the second service.

elderly patients of the medication should strictly comply with the provisions of doctors. Doctors can reduce under appropriate in the circumstances listed above dosage.

Nimesulide pill

A non-steroidal anti-inflammatory most prescribed drug – Nimesulide that contains dose of 100mg and it’s used for treating acute (short-term) pain, painful osteoarthritis (swelling in the joints), and Primary dysmennorhea (Period Pains).

Nimesuilde is first launched in 1985and currently it’s on the market in worldwide of over 50 countries as orginal product with the trademarks of Nise, Nimopen-MP, Nic-Spas, Nimulid, Nicip, e.t.c.

Nimesulide is a recently developed analgesic, antipyretic and anti-inflammatory agent that differs from conventional nonsteroidal anti-inflammatory drugs both in structure and pharmacological profile. Since nimesulide may be prescribed for patients receiving concomitant medication, the propensity for drug interactions exists.

This trademark also has several products by the brand name of Nimulid, Nise.

Popular NSAID drug Nimesulide is available in various forms including tablets, suppositories, soluble powders, and topical gels.

Major interactions involving interference with drug metabolism have not been described with Nimesulide.

Nimesulide is a leading NSAID’S srug with analgesic, antipyretic and anti-inflammatory Its main purpose is to treat acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea .

Nimesulide Tablet shows the result from pain within 15min from the drug intake

Nimesulide medicine uses

Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) which acts as a cyclooxygenase- 2 inhibitor. It has become a leading NSAID in over 50 countries worldwide.

Nimesulide tablet is used for the treatment of osteoarthritis, postoperative trauma, sports injuries, acute musculoskeletal disorders including tendonitis, tenosynovitis, sprains, strains and low back pain, ear, nose and throat disorders

Nimesulide a specific Cox-2 anti-inflammatory medication which have been turned out to be fundamentally more suitable in giving symptomatic alleviation for intense agony, symptomatic treatment of horrifying degenerative joint sickness and first dysmenorrhoea.

The European Medicines Agency has finished an review of the security and viability of solutions containing Nimesulide (capsules, tablets, suppositories and powder or granules for oral suspension).

Usage of Nimesulide 100mg- Tablet:

Nimesulide has less gastrointestinal adverse effects than other NSAIDs
It has superior benefit-risk ratio to other drugs with a comparable safety and tolerability to placebo.
Its multifactorial mode of action gives it a unique and broad action on inflammatory.
Nimesulide is also safe in sensitive asthmatic patients. It is reported to be beneficial in relieving the symptoms of rhinitis, rhinopharyngitis tubaritis and seceretory otitis media with concomitant antibiotic treatment.

Nimesulide synthesis

Nimesulide is a COX-2 selective drug which has the properties of antiinflammatory and antihistaminic, it also possesses analgesic properties.

Apart for the treatment of acute pain, osteoarthritis and primary dysmenorrhoea. Nimesulide is also being widely used for anticancer and antiviral agents.

A variety of new nimesulide derivatives were synthesized through incorporation of a 5-LOX pharmacophore into Nimesulide followed with some structural modifications. which were then characterized for dual enzyme inhibitors for these two types of enzymes (Cyclooxygenase-½ (COX-½) and 5-lipoxygenase (5-LOX) )

Nimesulide is available in various forms like powder/granules, gel, and suppositories.

Clinically it has proven that it supports a particularly good profile in terms of gastrointestinal tolerability.

Its main purpose is to treat acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea.

As for other NSAIDs the use of Nimesulide preffered for the shortest duration necessary to control symptoms in patients with acute pain or primary dysmenorrhoea. The efficacy of Nimesulide was consistently superior to placebo with its particularly rapid onset action.

Nimesulide medicine for osteoarthritis

Nimesulide drug was launched in Italy for the first time as Aulin and Mesulid in 1985 and is presently available in more than 50 countries worldwide with different trademarks.

Osteoarthritis is one of the most common joint disorders. The severity of pain often treated with nonsteroidal anti-inflammatory drug- Nimesulide. Nimesulide has already proved that the Worldwide experience shows nonsteroidal anti-inflammatory drug has a number of pharmacological properties that makes it favorable in the treatment of joint diseases.

Nimesulide is used for the treatment of post-traumatic inflammation, acute musculoskeletal disorders including sprains, strains, tendinitis, tenosynovitis, low back pain, periarthritis (shoulder pain) and osteoarthritis (joint pains), stiffness.

Apart from gastrointestinal safety It also has analgesic and antipyretic properties. Its multifactorial mode of action gives it a unique and broad action on inflammatory process.

Nimesulide brands such as Sulide, Nimalox, Nimesil, Nimulid, Nicip, Nimcap, Nise, Sulidene and Zolan.

 It has superior gastrointestinal safety as compared to other NSAIDs.

The maximum duration and dose of a treatment course with Nimesulide medicine is 15 days, 100 mg twice a day, to minimize the risk of hepatotoxicity.

Nimesulide tablet for headache

Postoperative headache may be caused by hypoglycemia and/or dehydration due to prolonged fasting, caffeine withdrawal, anxiety, and can be associated with preexisting migraine or headache.

NSAIDs- Nimesulide, is the first line pharmacological approaches to postoperative headache.

Nimesulide gives rapid onset of pharmacological action, good pain relief and stable effect for many hours is an ideal drug for postoperative headache with no contraindications.

It is also used for the treatment of acute musculoskeletal disorders including tendonitis, tenosynovitis, sprains, strains and low back pain, ear, nose and throat disorders, acute pain, osteoarthritis, primarydysmenorrhoea.

Nimesulide is available in various forms including tablets, suppositories, water-soluble powders, and topical gels.

The maximum duration of a treatment course with Nimesulide is 15 days.

Nimesulide 100mg Tablets/granules should be used for the shortest possible duration, as required by the clinical situation.