Nimesulide Solubility

Nimesulide is a preferential COX-2 inhibitor most commonly prescribed for the treatment of various inflammatory conditions such as tonsillitis, pharyngitis, stomatitis, rheumatoid arthritis, osteoarthritis, low back pain.

It has high anti-inflammatory, antipyretic. Solubility of Nimesulide was studied using different cosolvent mixtures and various classes of non-ionic surfactant.

Solubility Increased on solubilization of drug in semi-polar solvents and non-ionic surfactants. Solubility increased drastically (>70 mg/rnl) when polyethylene glycol 300 and polyethylene glycol 400 were used as solvents.

The quick dissolving tablets of Nimesulide contains superdisintegrants, that accelerates the disintegration of tablets by virtue of their ability to soak up great deal of water once exposed to binary compound surroundings.

Nimesulide Tablet

Nimesulide drug is a prescribed non-steroidal anti-inflammatory medication (NSAID) developed by Helsinn Healthcare with a multifactorial mode of action. Nimesulide is indicated for the treatment of acute pain and primary dysmenorrhoea. Nimesulide has superior canal safety as compared to other NSAIDs. Food, gender and advanced age have negligible effects on Nimesulide pharmacokinetics. It is available in a very form of forms like tablets, powder for dissolution in water, suppositories, mouth dissolving tablets and topical gel. Nimesulide's therapeutic value in effectively and rapidly controlling inflammation and pain is supported by vital clinical evidence. The prescription of a drug is suitable when the benefit is able to provide to a particular patient outweigh the risks associated with its use. A careful analysis of individual risk factors is therefore of crucial importance. The maximum duration and dose of a treatment course with Nimesulide is 15 days, 100 mg twice a day, to minimize the risk of hepatotoxicity.