Nimesulide Solubility

Nimesulide Solubility

Nimesulide is a unique non- steroidal anti-inflammatory drug that acts specifically on cyclo-oxygenase-2 and does not affect cyclo-oxygenase-1. Hence, it exerts its anti-inflammatory action characteristics of non- steroidal anti-inflammatory drug. Solubility of Nimesulide Increased on solubilization of drug in semi-polar solvents and non-ionic surfactants.

Solubility of Nimesulide was studied using different cosolvent mixtures and various classes of non-ionic surfactant. Solubility increased drastically (>70 mg/rnl) when polyethylene glycol 300 and polyethylene glycol 400 were used as solvents.

The quick dissolving tablets of Nimesulide contains superdisintegrants, that accelerates the disintegration of tablets by virtue of their ability to soak up great deal of water once exposed to binary compound surroundings.

Nimesulide is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, Nimesulide should first be dissolved in ethanol and then diluted with the aqueous buffer of choice. Nimesulide has a solubility of approximately <200 μg/ml in a 10% DMSO in PBS (pH 7.2) solution using this method.

Nimesulide Solubility

Nimesulide is a unique non- steroidal anti-inflammatory drug that acts specifically on cyclo-oxygenase-2 and does not affect cyclo-oxygenase-1. Hence, it exerts its anti-inflammatory action characteristics of non- steroidal anti-inflammatory drug. Solubility of Nimesulide Increased on solubilization of drug in semi-polar solvents and non-ionic surfactants.

Solubility of Nimesulide was studied using different cosolvent mixtures and various classes of non-ionic surfactant. Solubility increased drastically (>70 mg/rnl) when polyethylene glycol 300 and polyethylene glycol 400 were used as solvents.

The quick dissolving tablets of Nimesulide contains superdisintegrants, that accelerates the disintegration of tablets by virtue of their ability to soak up great deal of water once exposed to binary compound surroundings.

Nimesulide is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, Nimesulide should first be dissolved in ethanol and then diluted with the aqueous buffer of choice. Nimesulide has a solubility of approximately <200 μg/ml in a 10% DMSO in PBS (pH 7.2) solution using this method.

Nimesulide Solubility

Nimesulide is a preferential COX-2 inhibitor most commonly prescribed for the treatment of various inflammatory conditions such as tonsillitis, pharyngitis, stomatitis, rheumatoid arthritis, osteoarthritis, low back pain.

It has high anti-inflammatory, antipyretic. Solubility of Nimesulide was studied using different cosolvent mixtures and various classes of non-ionic surfactant.

Solubility Increased on solubilization of drug in semi-polar solvents and non-ionic surfactants. Solubility increased drastically (>70 mg/rnl) when polyethylene glycol 300 and polyethylene glycol 400 were used as solvents.

The quick dissolving tablets of Nimesulide contains superdisintegrants, that accelerates the disintegration of tablets by virtue of their ability to soak up great deal of water once exposed to binary compound surroundings.

Nimesulide Tablet Solubility

Nimesulide NSAID’s tablet is an efficient and safe therapeutic selection for the treatment of assorted painful inflammatory conditions like inflammation, sore throat, stomatitis, arthritis, degenerative joint disease, low back pain etc., with a speedy onset of analgesic activity.

The quick dissolving tablets of Nimesulide contains superdisintegrants, that accelerates the disintegration of tablets by virtue of their ability to soak up great deal of water once exposed to binary compound surroundings.

Nimesulide is soluble in organic solvents like alcohol, DMSO, and dimethyl formamide (DMF).

Nimesulide is out there in varied forms like Nimesulide Tablets, Nimesulide Powder/granules, Nimesulide Gel, suppositories.

Clinical proved that it is available to support a particularly good profile in terms of gastrointestinal tolerability.

The employment of Nimesulide is usually recommended for the shortest length necessary to regulate symptoms in patients with acute pain or primary dysmenorrhoea.