Nepar is a combination of Nimesulide and Paracetamol is a anti-inflammatory, analgesic. Available as nimesulide – 100mg and paracetamol – 500mg.
Pharmacodynamic
Nimesulide – is an inhibitor of cyclooxygenase so it inhibits synthesis of destructive prostaglandins and spares cytoprotective prostaglandins. Nimesulide appears to exert its effects also through a variety of other mechanisms and involves interference with the production action of mediators other than prostaglandins such as enzymes, toxic oxygen derivatives, cytokines, platelet activating factor and histamine.
Paracetamol – is a valuable central analgesic but weak peripheral anti-inflammatory agent and exhibits agent and exhibits antipyretic action.
Pharmacokinetic
Nimesulide – after oral administration the peak plasma concentrations of 1.98-9.85 mg/L are achieved within 1 to 3 hrs.
Paracetamol – is rapidly and completely absorbed from gastrointestinal tract. Peak plasma is achieved within 0.5 to 2 hrs.
Nimesulide suspension (1.5 mg/kg three times daily) or paracetamol syrup (10 mg/kg four times daily) were administered orally till fever resolved. blood heat was recorded and native pain and general discomfort assessed.
Indications
The other recent study with the patients aged between twelve and sixty years on the premise of analgesic effectiveness and tolerability has well-tried that the analgesic results of Nimesulide had a faster onset (<15 minutes) and was stronger (based on patient opinion). And were well tolerated.
Pharmacodynamic
Nimesulide – is an inhibitor of cyclooxygenase so it inhibits synthesis of destructive prostaglandins and spares cytoprotective prostaglandins. Nimesulide appears to exert its effects also through a variety of other mechanisms and involves interference with the production action of mediators other than prostaglandins such as enzymes, toxic oxygen derivatives, cytokines, platelet activating factor and histamine.
Paracetamol – is a valuable central analgesic but weak peripheral anti-inflammatory agent and exhibits agent and exhibits antipyretic action.
Pharmacokinetic
Nimesulide – after oral administration the peak plasma concentrations of 1.98-9.85 mg/L are achieved within 1 to 3 hrs.
Paracetamol – is rapidly and completely absorbed from gastrointestinal tract. Peak plasma is achieved within 0.5 to 2 hrs.
Nimesulide suspension (1.5 mg/kg three times daily) or paracetamol syrup (10 mg/kg four times daily) were administered orally till fever resolved. blood heat was recorded and native pain and general discomfort assessed.
Indications
- Sprains, wounds, injury
- Post Surgical pain
- Dental pain
- Arthritic pain
- Pyrexia of unknown origin
- Pain, fever inflammation accompanying respiratory tract infection and ENT conditions
- Gentio urinary inflammation
The other recent study with the patients aged between twelve and sixty years on the premise of analgesic effectiveness and tolerability has well-tried that the analgesic results of Nimesulide had a faster onset (<15 minutes) and was stronger (based on patient opinion). And were well tolerated.
No comments:
Post a Comment