Nimesulide Dose

Nimesulide medication is a non-steroidal anti-inflammatory drug, prescribed for painful inflammatory conditions, back pain, dysmenorrhea, postoperative pain, osteoarthritis, and fever.

Dosage:

The usual dose is 100mg twice a day.

Children: 5mg/kg of body weight in 2 or 3 divided doses.

The minimum effective dose should be used for the shortest duration to reduce the undesirable effects.

The maximum duration of a treatment course with Nimesulide is 15 days.

Nimesulide 100mg Tablets/granules should be used for the shortest possible duration, as required by the clinical situation.

Adults:
100mg bid after meal.

Elderly:
In elderly patients there is no need to reduce the daily dosage

Children (< 12 years):
Nimesulide 100mg Tablets/granules is contraindicated in these patients.

Adolescents (from 12 to 18 years):
on the basis of the kinetic profile in adults and on the pharmacodynamic characteristics of nimesulide, no dosage adjustment in these patients is necessary.

Nimesulide Tablet Synthesis

Nimesulide is a non-steroidal anti-inflammatory agent that is generally utilized as a part of the treatment of inflammatory torment which hinders the protein cyclooxygenase-2 (COX-2) and has better gastro-intestinal mediocrity in addition to different NSAIDs in its class.

Its approved signs are the treatment of intense torment, the symptomatic treatment of osteoarthritis and essential dysmenorrhoea, sports wounds and so on.

A variety of new Nimesulide derivatives were synthesized through incorporation of a 5-LOX pharmacophore into nimesulide followed with some structural modifications, which were then characterized for dual enzyme inhibitors for these two types of enzymes (Cyclooxygenase-½ (COX-½) and 5-lipoxygenase (5-LOX) ). Their structure-activity relationships (SARs) were studied, and compound 20f was found to be an excellent dual enzyme inhibitor.

Its binding conformation and interaction mode were studied with molecular docking experiments. Compound 20f could become a lead compound for further development for potential anti-inflammatory drugs.

Clinically it has demonstrated that it supports an especially good profile as far as gastrointestinal tolerability.

Nimesulide Brands

Nimesulide is a popular NSAID and available in various forms including tablets, suppositories, water-soluble powders, and topical gels.

It is an analgesic and antipyretic in action, apart from its anti inflammatory action. Nimesulide is always recommended to use under a licensed physician supervision and as per approved indications.

Nimesulide is distributed world-wide through a network of selected international partners.

The most popular brands are:

sulide, nimalox, mesulid, Drexel, Donulide, Aulin, Ainex, Heugan, Mesulid, Minapon, NeRelid, Edrigyl, Enetra, Eskaflam, Nexen, Nidolon, Nilden (Mexico), Nimulid, Nimutab, Nise, Nisulid, Nimed, Nimedex, Nimesil, Nodard Plus, Nicip (India), Novolid, Pain Lock(VIP Pharma India ), Relmex (Ecuador), Scaflam, Scaflan.

Why Nimesulide Drugs are Used?

The main purpose of using nimesulide are:

• To treat acute pain
• To treat osteoarthritis
• To treat primary dysmenorrhoea in adolescents and adults above 12 years old.

Nimesulide Tablets

Features:

• Amongst most effective yet gastro friendly
• Non steroidal anti inflammatory drug (NSAID)
• Nimesulide targets COX-2 an enzyme responsible for inflammation & pain.

Indications:

• Osteoarthritis
• Low back Pain
• Sports injury
• Dental pain
• Moderate pain & fever
• Dysmenorrhea

Uses of Nimesulide:Offered tablet has excellent gastrointestinal safety in comparison to other medication.

• Rapid onset of action within 15 minutes
• Rapidly relieves pain in arthritis

Nimesulide Offered tablet has excellent gastrointestinal safety in comparison to other medication.

Nimesulide Uses

Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) which acts as a cyclooxygenase- 2 inhibitor. It has become a leading NSAID in over 50 countries worldwide.

Nimesulide tablet is used for the treatment of osteoarthritis, postoperative trauma, sports injuries, acute musculoskeletal disorders including tendonitis, tenosynovitis, sprains, strains and low back pain, ear, nose and throat disorders.

Usage of Nimesulide 100mg- Tablet:

• Nimesulide has less gastrointestinal adverse effects than other NSAIDs.
• It has superior benefit-risk ratio to other drugs with a comparable safety and tolerability to placebo.
• Its multifactorial mode of action gives it a unique and broad action on inflammatory.
• Nimesulide is also safe in sensitive asthmatic patients. It is reported to be beneficial in relieving the symptoms of rhinitis, rhinopharyngitis tubaritis and seceretory otitis media with concomitant antibiotic treatment.
• Nimesulide has potent analgesic, anti-inflammatory and antipyretic activities.

Nimesulide tablet undergoes extensive biotransformation and has a relatively rapid onset of action, with meaningful reductions in pain and inflammation observed within 15 minutes from drug intake.

Its an anti-inflammatory with analgesic and antipyretic activity. It is also has low gastro-intestinal and renal toxicity.

Nimesulide Tablet for the treatment of Headache

Postoperative headache may be caused by hypoglycemia and/or dehydration due to prolonged fasting, caffeine withdrawal, anxiety, and can be associated with preexisting migraine or headache. NSAIDs- Nimesulide, is the first line pharmacological approaches to postoperative headache.

Nimesulide gives rapid onset of pharmacological action, good pain relief and stable effect for many hours is an ideal drug for postoperative headache with no contraindications.

It is also used for the treatment of acute musculoskeletal disorders including tendonitis, tenosynovitis, sprains, strains and low back pain, ear, nose and throat disorders, acute pain, osteoarthritis, primary dysmenorrhoea.

Dosage & When it is to be taken :

The usual dose is 100mg twice a day.

Children: 5mg/kg of body weight in 2 or 3 divided doses.

Nimesulide Gel

Nimesulide Gel (Nimesulide/Methyl Salicylate/Menthol/Capsaicin) is used to treat chronic and acute musculoskeletal disorders such as soft tissue injuries or non-articular rheumatic disorders, including discomfort in the muscles, tendonitis, back pain/ache, arthritis, tenosynovitis sprains, or strains.

Nimesulide is used topically as an analgesic with NSAID benefits and functions by inhibiting particular nerve impulses sent from the periphery to your central system, leading to a decrease of sensitivity from the kinds of symptoms.


Dosage and Administration

Nimesulide Gel is apply to the affected area, rubbing in a thin layer of the gel 2 to 4 times every day. For best results, wash the application area beforehand to clean away any oil, grease, or bacteria, allowing the gel to absorb more easily.

Nimesulide is available in assortment of structures like as tablets and syrup for oral organization and gels for topical application.

The anti-inflammatory activity of topically applied Nimesulide gel demonstrations particularly on cyclo-oxygenase-2 which applies less gastrointestinal antagonistic impacts than different NSAIDs

 

Nimesulide Tablets Use

Nimesulide is a popular NSAID and available in various forms including tablets, suppositories, water-soluble powders, and topical gels. It is an analgesic and antipyretic in action, apart from its anti inflammatory action.

It is absorbed rapidly and completely after oral administration.  Nimesulide is a prescription drug with important analgesic properties. Therefore it is always recommended to use this medicine under a licensed physician supervision

Nimesulide Tablet Uses:

The main purpose of using Nimesulide are:

• To treat acute pain
• To treat osteoarthritis
• To treat primary dysmenorrhoea in adolescents and adults above 12 years old.

It is also used for the treatment of  acute musculoskeletal disorders including tendonitis, tenosynovitis, sprains, strains and low back pain, ear, nose and throat disorders.

Nimesulide is used to treat  mild to moderate pain as well as to reduce fever, dental pain and inflammation

that is used to treat mild to moderate pain as well as reduce fever and inflammation.

Read more : http://www.ehow.com/about_5569318_nimesulide-side-effects.html

that is used to treat mild to moderate pain as well as reduce fever and inflammation.

Read more : http://www.ehow.com/about_5569318_nimesulide-side-effects.html

 

Nimesulide and Paracetamol Uses

Pharmacodynamic Nimesulide – is an inhibitor of cyclooxygenase so it inhibits synthesis of destructive prostaglandins and spares cytoprotective prostaglandins. Nimesulide appears to exert its effects also through a variety of other mechanisms and involves interference with the production action of mediators other than prostaglandins such as enzymes, toxic oxygen derivatives, cytokines, platelet activating factor and histamine.

Paracetamol – is a valuable central analgesic but weak peripheral anti-inflammatory agent and exhibits agent and exhibits antipyretic action.

Pharmacokinetic Nimesulide – after oral administration the peak plasma concentrations of 1.98-9.85 mg/L are achieved within 1 to 2hrs.

Paracetamol – is rapidly and completely absorbed from gastrointestinal tract. Peak plasma is achieved within 2 to 3hrs.

Nimesulide suspension (1.5 mg/kg three times daily) or paracetamol syrup (10 mg/kg four times daily) were administered orally till fever resolved. blood heat was recorded and native pain and general discomfort assessed.

According to the result, Nimesulide was as effective as paracetamol in reducing fever, local pain, and general discomfort. Nimesulide therefore appears to be a minimum of as effective as paracetamol in terms of antipyretic and anti inflammatory activity in children with inflammation of the upper tract and fever.

The other recent study with the patients aged between twelve and sixty years on the premise of analgesic effectiveness and tolerability has well-tried that the analgesic results of Nimesulide had a faster onset (<15 minutes) and was stronger (based on patient opinion). And were well tolerated.

Indications:

Sprains, wounds, injury Post surgical plan Dental pain Arthritic Pain pain, fever inflammation accompanying respiratory track infection and ENT conditions

Nimesulide Solubility

Nimesulide is a unique non- steroidal anti-inflammatory drug that acts specifically on cyclo-oxygenase-2 and does not affect cyclo-oxygenase-1. Hence, it exerts its anti-inflammatory action characteristics of non- steroidal anti-inflammatory drug. Solubility of Nimesulide Increased on solubilization of drug in semi-polar solvents and non-ionic surfactants.

Solubility of Nimesulide was studied using different cosolvent mixtures and various classes of non-ionic surfactant. Solubility increased drastically (>70 mg/rnl) when polyethylene glycol 300 and polyethylene glycol 400 were used as solvents.

The quick dissolving tablets of Nimesulide contains superdisintegrants, that accelerates the disintegration of tablets by virtue of their ability to soak up great deal of water once exposed to binary compound surroundings.

Nimesulide is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, Nimesulide should first be dissolved in ethanol and then diluted with the aqueous buffer of choice. Nimesulide has a solubility of approximately

<200 μg/ml in a 10% DMSO in PBS (pH 7.2) solution using this method.

Nimesulide Tablet Benefits

NSAIDs prescribed painkiller drug- Nimesulide tablet is used for the treatment of acute pain, Primary dysmennorhea and also to treat degenerative joint disease.

Nimesulide tablet was launched in Italy for the first time as Aulin and Mesulid in 1985 and is presently available in more than 50 countries worldwide.

It is available in a variety of forms: tablets, powder for dissolution in water, suppositories, mouth dissolving tablets and topical gel.

Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.

Nimesulide also has superior gastrointestinal safety as compared to other NSAIDs.

NImesulide is available in the dosage of 100mg for tablets, 100mg for granules for oral suspension, 200mg for suppositories and 3% of gel.

The prescribed duration for the tablet to use is15 days and the dosage to be used is 100mgs.

Nimesulide tablet should be used under doctor supervision.

Nimesulide Drug Bank Medicine

Nimesulide Indication:

It is used for the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old. It also proven that Food, gender and advanced age have negligible effects on nimesulide pharmacokinetics.

Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties.

Brands:
Nimesulide is accessible in worldwide among 50 nations with different brands like Sulide, Nimalox, Nimesil, Nimulid, Nicip, Nimcap, Nise, Sulidene and Zolan.

Nimesulide tablets also give relief from headaches and mild pains and aches

Nimesulide Painkiller Drug

Nimesulide is used in giving relief from acute pain associated with rheumatoid arthritis, osteoarthritis and primary dysmenorrhoea in adolescents and adults.

The drug is also an effective antipyretic and used to treat headaches and flu. It is also used in treating inflammatory conditions in humans and pain caused by arthritis or severe injury.

Nimesulide is a popular NSAID and available in various forms including tablets, suppositories, water-soluble powders, and topical gels.

Working of Nimesulide

It acts by inhibiting the release of tumour necrosis factor-alpha, acts as a competitive inhibitor of histamine release and reduces superoxide anion formation

Nimesulide Dosage

Adults: 100 mg twice daily
Children: 5mg/kg of body weight in 2 or 3 divided doses.