Nise pain relief tablet

''Nise'' tablet is a trademark for the drug ''Nimesulide'' which is non-steroidal anti-inflammatory drug (NSAID)
  with analgesic and antipyretic properties.

  It is used for the treatment of acute pain, Primary dysmennorhea and also to treat degenerative joint disease.

 Nimesulide drug was launched in Italy for the first time as Aulin and Mesulid in 1985 and is presently available     in more than 50 countries worldwide with different trademarks such as Nise, Sulide, Nimalox, Nimesil, Nimulid, Nicip, Nimcap, Sulidene, and Zolan etc.

It has superior gastrointestinal safety as compared to other NSAIDs.

Nise tablet also shows rapid analgesic activity which gives reductions for the pain within 15 minutes from drug intake.

It must be used under supervision by a doctor in accordance with the approved indications and in compliance with the recommendations.

 

Nise medicine has the rapid onset of analgesic action which shows the immediate relief within the 15 min from the drug intake for the acute pain.

Nise tablet for rapid onset analgesic action

Nise tablet is a prescribed Non-steroidal anti-inflammatory drug with multifactorial mode of action,characterized by a fast onset of analgesic activity. It’s one of the brand for the Nimesulide medicine.

It’s multifactorial mode of action gives the best results in the treatment of Acute (short term) pain, Painful osteoarthritis (Swelling in the joints) and Primary dysmennorhea ( Period Pains).

Clinical studies have been carried out in a wide variety of acute inflammatory and painful conditions with the aim of evaluating the analgesic activity of Nise.

These studies have proven that efficacy of Nise has a rapid pain relief with in the 15min from drug intake.

Nimesulide is a prescription-only drug and must be prescribed by a licensed physician after careful evaluation of the patient’s characteristics and needs. It is preffered to be used for the shortest duration.

Nimesulide Combination

The generic Nimesulide combination is manufactured by 399 companies and has nearly 522 Brands of Generics of Nimesulide.

Nimesulide is a Non steroidal anti inflammatory drug (NSAID) and targets COX-2 an enzyme responsible for inflammation & pain.

The Nimesulide is preferably used in the composition in an amount of 0.1-5% by weight, more preferably in an amount of 0.1-3% by weight, most preferably in an amount of around 1 % by weight of the composition.

Some of brands of Nimesulide are:

• Nepar – Nimuselide 100 mg + Paracetamol 500 mg
• Nimular Plus – Nimesulide, Acetaminophen
• Nipar (100 mg) – Nimesulide, Paracetamol
• Abinim-P – Nimesulide 100 mg, paracetamol 500 mg.Nimesulide is distributed world-wide through a network of selected international partners.

Nimesulide is mainly used for the treatment of:

• Back Pain
• Dysmenorrhea
• Osteoarthritis
• Rheumatoid Arthritis

Nimesulide is always recommended to use under a licensed physician supervision

Nimesulide drug information

Nimesulide medication developed by Helsinn Healthcare is a non-steroidal anti-inflammatory drug, indicated for painful inflammatory conditions, back pain, dysmenorrhea, postoperative pain, osteoarthritis, and fever. Nimesulide tablets are authorised in a number of Member States. They are only available with a prescription. 

It also used for the treatment of

• Skin Tone
• Heart Disease
• Dry Skin

It posses anti-inflammatory and analgesic properties. it’s an ethical medicine suggested to use medicine beneath authorised physician supervision.

Nimesulide is also available in the form of dissolving tablets, granules for oral suspension, and Gel. The fast dissolving tablets of Nimesulide contains superdisintegrants, which accelerates the disintegration of tablets by virtue of their ability to absorb large amount of water when exposed to aqueous environment.

The Nimesulide Tablets are highly effective in reducing pain, inflammation and also helps in better penetration of the antibiotics.

Nimesulide Analgesic Action

Nimesulide drug for pain relief has a relatively rapid onset of the analgesic action for the patients suffering from acute pain which shows meaningful reductions observed within 15 minutes from drug intake.

Nimesulide is a prescription-only drug and must be prescribed by a licensed physician after careful evaluation of the patient’s characteristics and needs.
As per the recent evaluations on the safety profile of nimesulide confirms that nimesulide has a favourable benefit/risk profile in the approved indications.

Nimesulide shows multifactorial mode of action for the treatment of for post-traumatic inflammation, acute musculoskeletal disorders including sprains, strains, tendinitis, tenosynovitis, low back pain, periarthritis (shoulder pain) and osteoarthritis (joint pains), stiffness.

Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.

Nimesulide tablet has great analgesic and antipyretic properties which is nothing but relief from pain and reduction of body temperature.

The overall safety profile of nimesulide is in line with that of all other NSAIDs. As with all drugs, it must be used in the most appropriate way to guarantee its best therapeutic value.

As for other NSAIDs the use of Nimesulide is preffered for the shortest duration necessary to control symptoms in patients with acute pain or primary dysmenorrhoea. The efficacy of Nimesulide was consistently superior to placebo with its particularly rapid onset action.

Nimesulide synthesis

Nimesulide is a COX-2 selective drug which has the properties of antiinflammatory and antihistaminic, it also possesses analgesic properties.

Apart for the treatment of acute pain, osteoarthritis and primary dysmenorrhoea. Nimesulide is also being widely used for anticancer and antiviral agents.

A variety of new nimesulide derivatives were synthesized through incorporation of a 5-LOX pharmacophore into Nimesulide followed with some structural modifications. which were then characterized for dual enzyme inhibitors for these two types of enzymes (Cyclooxygenase-½ (COX-½) and 5-lipoxygenase (5-LOX) )

Nimesulide is available in various forms like powder/granules, gel, and suppositories.

Clinically it has proven that it supports a particularly good profile in terms of gastrointestinal tolerability.

Its main purpose is to treat acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea.

As for other NSAIDs the use of Nimesulide preffered for the shortest duration necessary to control symptoms in patients with acute pain or primary dysmenorrhoea. The efficacy of Nimesulide was consistently superior to placebo with its particularly rapid onset action.

Nimesulide solubility

NSAID drug NImesulide has proven benefits in the treatment of Acute (short term) pain, Painful osteoarthritis (Swelling in the joints) and Primary dysmennorhea (Period Pains).

Nimesulide is available in various forms like Nimesulide Tablets, Nimesulide Powder, Nimesulide Gell, suppositories etc.

Nimesulide is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF). 

nimesulide is an effective and safe therapeutic choice for the treatment of various painful inflammatory conditions, with a rapid onset of analgesic activity.

Nimesulide is a unique non- steroidal anti-inflammatory drug that acts specifically on cyclo-oxygenase-2 and does not affect cyclo-oxygenase-1. Hence, it exerts its anti-inflammatory action characteristics of non- steroidal anti-inflammatory drug. Solubility of Nimesulide Increased on solubilization of drug in semi-polar solvents and non-ionic surfactants.

Solubility of Nimesulide was studied using different cosolvent mixtures and various classes of non-ionic surfactant. Solubility increased drastically (>70 mg/rnl) when polyethylene glycol 300 and polyethylene glycol 400 were used as solvents.

The quick dissolving tablets of Nimesulide contains superdisintegrants, that accelerates the disintegration of tablets by virtue of their ability to soak up great deal of water once exposed to binary compound surroundings.

Nimesulide structure

Nimesulide is generally utilized as a part of the treatment of inflammatory torment which hinders the protein cyclooxygenase-2 (COX-2) and has better gastro-intestinal mediocrity in addition to different NSAIDs in its class.

Nimesulide (4-nitro-2-phenoxymethanesulfoanilide) This compound, a by-product of p-nitrophenyl methane series sulfa, is structurally a singular non-steroidal anti-inflammatory drug.

It is available in more than 50 countries worldwide.

Features:

• Amongst most effective yet gastro friendly
• Non steroidal anti inflammatory drug (NSAID)
• Nimesulide targets COX-2 an enzyme responsible for inflammation & pain.

Uses of Nimesulide:

• Nimesulide tablet has excellent gastrointestinal safety in comparison to other medication.
• Rapid onset of action within 15 minutes
• Rapidly relieves pain in arthritis

Indications:

• acute pain
• primary dysmenorrhoea

Nimesulide gel

Nimesulide Gel

Nimesulide is available in the market in various forms including tablets (100 mg), granules for oral suspension (100 mg), suppositories (200 mg) and gel (3%).

Nimesulide Gel should be applied to the affected area, for 2 to 4 times every day.

Gel is used for the treatment of chronic and acute musculoskeletal disorders including discomfort in the muscles, tendonitis (cord), back pain/ache, arthritis, tenosynovitis(swelling in tendon) sprains, or strains.

Some patients were analysed for assessing the efficacy and safety of this gel. 

This studies results in better relief from pain and inflammation(redness/ swelling in a part of a body) parameters in more number of patients with nimesulide Gel.

Nimesulide exhibited better efficacy, and demonstrated faster onset of action.

 Nimesulide provides significant analgesic (painrelief) activity when applied topically. Peak analgesic effect was observed at 120 min from teatment

It functions by inhibiting particular nerve impulses sent from the periphery to your central system, leading to a decrease of sensitivity from the kinds of symptoms associated with the conditions above.

Nimesulide Analgesic action and Antipyretic properties

Nimesulide Analgesic action and Antipyretic properties

Nimesulide drug for pain relief has a relatively rapid onset of the analgesic action for the patients suffering from acute pain which shows meaningful reductions observed within 15 minutes from drug intake.

Nimesulide is a prescription-only drug and must be prescribed by a licensed physician after careful evaluation of the patient’s characteristics and needs.
As per the recent evaluations on the safety profile of nimesulide confirms that nimesulide has a favourable benefit/risk profile in the approved indications.

Nimesulide shows multifactorial mode of action for the treatment of for post-traumatic inflammation, acute musculoskeletal disorders including sprains, strains, tendinitis, tenosynovitis, low back pain, periarthritis (shoulder pain) and osteoarthritis (joint pains), stiffness.

Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.

Nimesulide tablet has great analgesic and antipyretic properties which is nothing but relief from pain and reduction of body temperature.

The overall safety profile of nimesulide is in line with that of all other NSAIDs. As with all drugs, it must be used in the most appropriate way to guarantee its best therapeutic value.

As for other NSAIDs the use of Nimesulide is preffered for the shortest duration necessary to control symptoms in patients with acute pain or primary dysmenorrhoea. The efficacy of Nimesulide was consistently superior to placebo with its particularly rapid onset action.

Nimesulide Drugbank

Nimesulide Drugbank

Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties which, preferentially inhibits the enzyme cyclooxygenase-2 (COX-2) and has better gastro-intestinal tolerability among other NSAIDs in its class

Its approved indications are the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea, sports injuries etc.

It is used for treatment of all types of pains resulting from sports injury, depression etc.

Nimesulide dose should be taken by prescription of physician and doctor which will help to take proper dose for good result.

Pharmacology: Food, gender and advanced age have negligible effects on Nimesulide pharmacokinetics.

Brands:

Nimesulide is accessible in worldwide among 50 nations with different brands like Sulide, Nimalox, Nimesil, Nimulid, Nicip, Nimcap, Nise, Sulidene and Zolan.

Nimesulide 100mg

Nimesulide Tablet 100mg

The best prescribed Nimesulide tablet is used for the treatment of acute pain, Primary dysmennorhea and also to treat degenerative joint disease.

Forms: A variety of Nimesulide forms are available in the market like in the form of tablets and syrup for oral administration and gels for topical application.

Nimesulide 100mg Therapeutic indications:

• Treatment of acute pain
• Symptomatic treatment of painful osteoarthritis
• Primary dysmenorrhoea.

Nimesulide 100mg Tablets/granules should be used for the shortest possible duration, as required by the clinical situation.

Absorption:
Well absorbed from GI tract following oral admin. Peak plasma levels:1-3 hours. With bid admin of 100 mg, steady-state is achieved within 24-36 hours.

Nimesulide 100mg Uses:

• Analgesic and antipyretic.
• Rheumatoid arthritis, osteoarthritis, other degenerative joint disorders.
• Musculo skeletal disorders.
• Thrombophlebitis.

Nimesulide is commercially available in Europe as tablets (100 mg), granules for oral suspension (100 mg), suppositories (200 mg) and gel (3%).

Nimesulide Combination

Monday, November 2, 2015

Nimesulide Combination

The generic Nimesulide combination is manufactured by 399 companies and has nearly 522 Brands of Generics of Nimesulide.

Nimesulide is a Non steroidal anti inflammatory drug (NSAID) and targets COX-2 an enzyme responsible for inflammation & pain.

The Nimesulide is preferably used in the composition in an amount of 0.1-5% by weight, more preferably in an amount of 0.1-3% by weight, most preferably in an amount of around 1 % by weight of the composition.

Some of brands of Nimesulide are:

• Nepar – Nimuselide 100 mg + Paracetamol 500 mg
• Nimular Plus – Nimesulide, Acetaminophen
• Nipar (100 mg) – Nimesulide, Paracetamol
• Abinim-P – Nimesulide 100 mg, paracetamol 500 mg.Nimesulide is distributed world-wide through a network of selected international partners.

Nimesulide is mainly used for the treatment of:

• Back Pain
• Dysmenorrhea
• Osteoarthritis
• Rheumatoid Arthritis

Nimesulide is always recommended to use under a licensed physician supervision

Nimesulide Gel Uses

Nimesulide is available in the market in various forms including tablets (100 mg), granules for oral suspension (100 mg), suppositories (200 mg) and gel (3%).

Nimesulide Gel should be applied to the affected area, for 2 to 4 times every day.

Gel is used for the treatment of chronic and acute musculoskeletal disorders including discomfort in the muscles, tendonitis (cord), back pain/ache, arthritis, tenosynovitis(swelling in tendon) sprains, or strains.

Some patients were analysed for assessing the efficacy and safety of this gel. This studies results in better relief from pain and inflammation(redness/ swelling in a part of a body) parameters in more number of patients with Nimesulide Gel.

Nimesulide exhibited better efficacy, and demonstrated faster onset of action. Nimesulide provides significant analgesic (painrelief) activity when applied topically. Peak analgesic effect was observed at 120 min from treatment.

It functions by inhibiting particular nerve impulses sent from the periphery to your central system, leading to a decrease of sensitivity from the kinds of symptoms associated with the conditions above.

Nimesulide Tablets for Treatement of Headache

Nimesulide Tablets for Treatement of Headache

Postoperative headache may be caused by hypoglycemia and/or dehydration due to prolonged fasting, caffeine withdrawal, anxiety, and can be associated with preexisting migraine or headache.

NSAIDs- Nimesulide, is the first line pharmacological approaches to postoperative headache.

Nimesulide gives rapid onset of pharmacological action, good pain relief and stable effect for many hours is an ideal drug for postoperative headache with no contraindications.

It is also used for the treatment of acute musculoskeletal disorders including tendonitis, tenosynovitis, sprains, strains and low back pain, ear, nose and throat disorders, acute pain, osteoarthritis, primarydysmenorrhoea.

Dosage & When it is to be taken : 

The usual dose is 100mg twice a day.

Children: 5mg/kg of body weight in 2 or 3 divided doses.

Nimesulide Tablets for Headache

Nimesulide Tablets for Treatement of Headache

Postoperative headache may be caused by hypoglycemia and/or dehydration due to prolonged fasting, caffeine withdrawal, anxiety, and can be associated with preexisting migraine or headache.

NSAIDs- Nimesulide, is the first line pharmacological approaches to postoperative headache.

Nimesulide gives rapid onset of pharmacological action, good pain relief and stable effect for many hours is an ideal drug for postoperative headache with no contraindications.

It is also used for the treatment of acute musculoskeletal disorders including tendonitis, tenosynovitis, sprains, strains and low back pain, ear, nose and throat disorders, acute pain, osteoarthritis, primarydysmenorrhoea.

Dosage & When it is to be taken : 

The usual dose is 100mg twice a day.

Children: 5mg/kg of body weight in 2 or 3 divided doses.

Nimesulide Tablet Dosage

The main purpose of Nimesulide tablets is for the treatment of painful inflammatory conditions, back pain, dysmenorrhea, postoperative pain, osteoarthritis, and fever.

The usual dose is 100mg twice a day.
Children: 5mg/kg of body weight in 2 or 3 divided doses.

The minimum effective dose should be used for the shortest duration to reduce the undesirable effects.

The maximum duration of a treatment course with Nimesulide is 15 days.

Nimesulide 100mg Tablets/granules should be used for the shortest possible duration, as required by the clinical situation.

Adults:
100mg bid after meal.

Elderly:
In elderly patients there is no need to reduce the daily dosage

Children (< 12 years):
Nimesulide 100mg Tablets/granules is contraindicated in these patients.

Adolescents (from 12 to 18 years):
on the basis of the kinetic profile in adults and on the pharmacodynamic characteristics of nimesulide, no dosage adjustment in these patients is necessary.

Oral dosage form prescribed for the shortest duration

In adults:100 mg In children: 5 mg/kg/day in 2 or 3 divided doses.

Nimesulide has superior gastrointestinal safety as compared to other NSAIDs. Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.

Nimesulide tablet prevents cancer by inhibiting the proliferation of various types of cancer cells mainly via COX-2 independent mechanisms. It is also used for dry skin, to improve skin-tone,and to increase energy.

Nimesulide treatment also brought about an immediate and significant improvement in over-all pain, exudation, oedema and headache.

Nimesulide Tablet for Osteoarthritis

Osteoarthritis (OA) is caused by aging joints, injury, and obesity. OA symptoms include joint pain and stiffness.

Nimesulide is used for the treatment of post-traumatic inflammation, acute musculoskeletal disorders including sprains, strains, tendinitis, tenosynovitis, low back pain, periarthritis (shoulder pain) and osteoarthritis (joint pains), stiffness.

Nimesulide drugs also reduce inflammation. Inflammation is the body's response to irritation or injury and is characterized by redness, warmth, swelling, and pain. 

Nimesulide drug was launched in Italy for the first time as Aulin and Mesulid in 1985 and is presently available in more than 50 countries worldwide with different trademarks.

It is an analgesic and antipyretic in action. Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.

The maximum duration and dose of a treatment course with Nimesulide medicine is 15 days, 100 mg twice a day, to minimize the risk of hepatotoxicity.

Nimesulide Tablet Chemical Formula

Nimesulide Tablet Chemical Formula

Nimesulide, a wide prescribed medication analgesic drug belongs to BCS category II and exhibit low and variable oral bioavailability.

Nimesulide (4-nitro-2-phenoxymethanesulfoanilide) may be a selective Cox-2 anti-inflammatory drug drug. This compound, a by-product of p-nitrophenyl methane series sulfa, is structurally a singular non-steroidal anti-inflammatorydrug. It belongs to selective COX-2inhibitors, with a potent analgesic activity.

it’s indicated as second line treatment for acute pain, symptomatic treatment of painful degenerative joint disease and first dysmenorrhoea.

It’s conjointly used for the treatment of skin-tone, Heart diseases and dry skin.

Features include :

• Fascinating results
• Useful and helpful
• No facet effects
• Quick and fast effects

Usage of Nimesulide 100mg- pill :

• Analgesic and antipyretic.
• Rheumatic inflammatory disease, degenerative joint disease, alternative chronic joint disorders treatment
• Musculo skeletal disorders treatment
• Thrombophlebitis.
• Improves skintone
• Heart Diseases
• Dry Skin
• Cancer treatment

Nimesulide Uses

Nimesulide Tablet Uses

Nimesulide medication is a non-steroidal anti-inflammatory drug with analgesic and antyperetic properties, prescribed for painful inflammatory conditions, back pain, dysmenorrhea and etc.

The usual dosage of Nimesulide is 100mg twice a day. For children it should be taken 5mg/kg of body weight in 2 or 3 divided doses

Nimesulide is used to reduce:

1. Osteoarthritis
2. Low back Pain
3. Sports injury
4. Dental pain
5. Moderate pain & fever
6. Dysmenorrhea

Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.

Nimesulide is reported to be beneficial in relieving the symptoms of rhinitis, rhinopharyngitis tubaritis and seceretory otitis media with concomitant antibiotic treatment.