Nimesulide medicine for osteoarthritis

Nimesulide drug was launched in Italy for the first time as Aulin and Mesulid in 1985 and is presently available in more than 50 countries worldwide with different trademarks.

Osteoarthritis is one of the most common joint disorders. The severity of pain often treated with nonsteroidal anti-inflammatory drug- Nimesulide. Nimesulide has already proved that the Worldwide experience shows nonsteroidal anti-inflammatory drug has a number of pharmacological properties that makes it favorable in the treatment of joint diseases.

Nimesulide is used for the treatment of post-traumatic inflammation, acute musculoskeletal disorders including sprains, strains, tendinitis, tenosynovitis, low back pain, periarthritis (shoulder pain) and osteoarthritis (joint pains), stiffness.

Apart from gastrointestinal safety It also has analgesic and antipyretic properties. Its multifactorial mode of action gives it a unique and broad action on inflammatory process.

Nimesulide brands such as Sulide, Nimalox, Nimesil, Nimulid, Nicip, Nimcap, Nise, Sulidene and Zolan.

 It has superior gastrointestinal safety as compared to other NSAIDs.

The maximum duration and dose of a treatment course with Nimesulide medicine is 15 days, 100 mg twice a day, to minimize the risk of hepatotoxicity.

Nimesulide Efficacy

The efficacy of nimesulide (100mg twice daily) was compared with that of naproxen (500mg twice daily) in 53 adult patients with nonbacterial acute inflammation of the ear, nose or throat in a double-blind phase III clinical investigation. Both drugs were administered orally after meals for a mean duration of 8.7 days.

In this setting, nimesulide was associated with relief of pain and inflammatory signs (exudation and swelling). Indeed, treatment with nimesulide led to clinical improvement superior to that obtained with naproxen in terms of both rapidity of action and improvement of the symptoms at the end of therapy. Nimesulide therapy was also very well tolerated and no patient reported an adverse event. In contrast, 2 naproxen-treated patients reported episodic gastralgia of moderate intensity.

Nimesulide's therapeutic value in effectively and rapidly controlling inflammation and pain is supported by significant clinical evidence.

Clinical studies have been carried out in a wide variety of acute inflammatory and painful conditions with the aim of evaluating the analgesic activity of nimesulide in comparison to placebo and to some of the most common NSAIDs.

In these studies, the efficacy of nimesulide was consistently superior to placebo and at least comparable, or in some cases superior, to that observed for the reference drugs, with a particularly fast onset of the analgesic action.

Nimesulide posses analgesic properties with multifactorial mode of action for the treatment of musculoskeletal system, dysmenorrhoea, and acute pain.
The abilities of NSAID’s drug nimesulide to inhibit COX-2 preferentially and to exert other novel anti-inflammatory actions are consistent with good efficacy and safety with highly effective in reducing pain, inflammation and also helps in better penetration of the antibiotics.

It also undergoes extensive biotransformation. The recent study on the basis of analgesic activity of Nimesulide has proved that it has a quicker onset which shows relief from pain relief and inflammation within 15 minutes from drug intake.

Nimesulide is recommended for the shortest duration necessary to control symptoms in patients with acute pain or primary dysmenorrhoea.

Nimesulide Uses

Nimesulide Tablet Uses

Nimesulide medication is a non-steroidal anti-inflammatory drug with analgesic and antyperetic properties, prescribed for painful inflammatory conditions, back pain, dysmenorrhea and etc.

The usual dosage of Nimesulide is 100mg twice a day. For children it should be taken 5mg/kg of body weight in 2 or 3 divided doses

Nimesulide is used to reduce:

1. Osteoarthritis
2. Low back Pain
3. Sports injury
4. Dental pain
5. Moderate pain & fever
6. Dysmenorrhea

Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.

Nimesulide is reported to be beneficial in relieving the symptoms of rhinitis, rhinopharyngitis tubaritis and seceretory otitis media with concomitant antibiotic treatment.

Nimesulide Tablets Use

Nimesulide Tablets Use

Nimesulide is a popular NSAID prescribed for painful inflammatory conditions, back pain, dysmenorrhea associated with musculoskeletal system, Thrombophlebitis, dental pain and in ENT inflammation. 

Nimesulide is a prescription drug with important analgesic properties. Therefore it is always recommended to use this medicine under a licensed physician supervision and as per approved indications.

Nimesulide is available in various forms including tablets, suppositories, water-soluble powders, and topical gels. It is an analgesic and antipyretic in action.

Nimesulide Drug uses: 

• Nimesulide has less gastrointestinal adverse effects than other NSAIDs.
• It has superior benefit-risk ratio to other drugs with a comparable safety and tolerability to placebo.
• Rapid onset of action within 15 minutes
• Rapidly relieves pain in arthritis
• Its multifactorial mode of action gives it a unique and broad action on inflammatory.
• Nimesulide is also safe in sensitive asthmatic patients.
• It is reported to be beneficial in relieving the symptoms of rhinitis, rhinopharyngitis tubaritis and seceretory otitis media with concomitant antibiotic treatment.
• Nimesulide has potent analgesic, anti-inflammatory and antipyretic activities.

Nimesulide Brands in India

Nimesulide Brands in India

NSAID’s tablet Nimesulide is a widely prescribed anti-inflammatory analgesic drug belongs to BCS class II which is required for the quick treatment of severe muscular pains and inflammatory problems.

NSAID’s tablet Nimesulide is been available since 1985 and sanction with assorted trade names in worldwide in abundance of 50 countries.

Nimesulide is distributed world-wide through a network of selected international partners. 

Different trademarks of Nimesulide are: For Oral Use: Sulide, Nimalox, Nimesil, Nimulid, Nicip (India),, Nimcap, Nise, Sulidene and Zolan, Pain Lock(VIP Pharma India ), Nilden (Mexico),

Why Nimesulide Drugs are Used?

The main purpose of using Nimesulide are:

• To treat acute pain
• To treat osteoarthritis
• To treat primary dysmenorrhoea in adolescents and adults above 12 years old.

Nimesulide tablet incorporates:

• Fast results
• Helpful and supportive
• No feature impacts
• Fast and quick effects

Nimesulide treatment for acute pain

Nimesulide tablet is a prescription anti-inflammatory drug used for treating acute (short-term) pain, painful osteoarthritis (swelling in the joints), and Primary dysmennorhea (Period Pains).

Original nimesulide was developped by Helsinn Healthcare and is marketed world-wide through a network of selected international partners.

Clinical studies have been carried out in a wide variety of acute inflammatory and painful conditions with the aim of evaluating the analgesic activity of nimesulide in comparison to placebo and to some of the most common NSAIDs.

In these studies, it is observed that the efficacy of nimesulide was consistently superior to placebo with a particularly fast onset of the analgesic in action.

The rapid action shows the immediate relief within the 15 min from the drug intake for the acute pain.

The maximum duration and dose of a treatment course with nimesulide is 15 days, 100 mg twice a day, to minimize the risk of hepatotoxicity.

Nimesulide should only be prescribed as second line treatment. The decision to prescribe nimesulide should be based on assessment of the individual patient’s overall risks.

Nimesulide Uses

Nimesulide Tablet Uses

Nimesulide medication is a non-steroidal anti-inflammatory drug with analgesic and antyperetic properties, prescribed for painful inflammatory conditions, back pain, dysmenorrhea and etc.

The usual dosage of Nimesulide is 100mg twice a day. For children it should be taken 5mg/kg of body weight in 2 or 3 divided doses

Nimesulide is used to reduce:

1. Osteoarthritis
2. Low back Pain
3. Sports injury
4. Dental pain
5. Moderate pain & fever
6. Dysmenorrhe                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
   Nimesulide Drug uses: 
   
7. Nimesulide has less gastrointestinal adverse effects than other NSAIDs.
8. It has superior benefit-risk ratio to other drugs with a comparable safety and tolerability to placebo.
9. Rapid onset of action within 15 minutes
10. Rapidly relieves pain in arthritis
11. Its multifactorial mode of action gives it a unique and broad action on inflammatory.
12. Nimesulide is also safe in sensitive asthmatic patients.
13. It is reported to be beneficial in relieving the symptoms of rhinitis, rhinopharyngitis tubaritis and seceretory otitis media with concomitant antibiotic treatment.
14. Nimesulide has potent analgesic, anti-inflammatory and antipyretic activities.

Nimesulide composition

Nimesulide is a non-steroidal anti-inflammatory agent that is widely used in the treatment of inflammatory pain.The efficacy and tolerability of nimesulide was consistently superior to placebo.

Nimesulide tablet undergoes extensive biotransformation and has a relatively rapid onset of action, with meaningful reductions in pain and inflammation observed within 15 minutes from drug intake.

The drug belongs to the class II of Biopharmaceutical Classification System (low solubility, high permeability) and therefore, absorption of this drug is limited by its dissolution.

 Nimesulide is a Non steroidal anti inflammatory drug (NSAID) and targets COX-2 an enzyme responsible for inflammation & pain.

The nimesulide is preferably used in the composition in an amount of 0.1-5% by weight, more preferably in an amount of 0.1-3% by weight, most preferably in an amount of around 1 % by weight of the composition.

This medication is for the most part used as an issue of the treatment of inflammatory torment and also used for postoperative trauma, sports injuries, acute musculoskeletal disorders.

Uses of Nimesulide:

• Rapid onset of action within 15 minutes
• Rapidly relieves pain in arthritis

The nimesulide is preferably used in the composition in an amount of 0.1-5% by weight, more preferably in an amount of 0.1-3% by weight, most preferably in an amount of around 1 % by weight of the composition.

This medication is for the most part used as an issue of the treatment of inflammatory torment and also used for postoperative trauma, sports injuries, acute musculoskeletal disorders

Nimesulide Composition

Nimesulide is a Non steroidal anti inflammatory drug (NSAID) and targets COX-2 an enzyme responsible for inflammation & pain.

The Nimesulide is preferably used in the composition in an amount of 0.1-5% by weight, more preferably in an amount of 0.1-3% by weight, most preferably in an amount of around 1 % by weight of the composition.

This medication is for the most part used as an issue of the treatment of inflammatory torment and also used for postoperative trauma, sports injuries, acute musculoskeletal disorders.

Nimesulide have pain relieving and antipyretic properties which, specially restrains the protein cyclooxygenase-2 (COX-2) and has better gastro-intestinal bearableness in addition to different NSAIDs in its class.

Forms: A variety of Nimesulide forms are available in the market like in the form of tablets and syrup for oral administration and gels for topical application.

Dose: Nimesulide is available with the dosage of 100 mg for tablets, 100 mg for granules for oral suspension, 200mg for suppositories and 3% of gel.

Nimesulide Analgesic action and Antipyretic properties

Nimesulide drug for pain relief has a relatively rapid onset of the analgesic action for the patients suffering from acute pain which shows meaningful reductions observed within 15 minutes from drug intake.

Nimesulide is a prescription-only drug and must be prescribed by a licensed physician after careful evaluation of the patient’s characteristics and needs.

As per the recent evaluations on the safety profile of nimesulide confirms that nimesulide has a favourable benefit/risk profile in the approved indications.

Nimesulide shows multifactorial mode of action for the treatment of for post-traumatic inflammation, acute musculoskeletal disorders including sprains, strains, tendinitis, tenosynovitis, low back pain, periarthritis (shoulder pain) and osteoarthritis (joint pains), stiffness.

Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.

Nimesulide tablet has great analgesic and antipyretic properties which is nothing but relief from pain and reduction of body temperature.

The overall safety profile of nimesulide is in line with that of all other NSAIDs. As with all drugs, it must be used in the most appropriate way to guarantee its best therapeutic value.

As for other NSAIDs the use of Nimesulide is preffered for the shortest duration necessary to control symptoms in patients with acute pain or primary dysmenorrhoea. The efficacy of Nimesulide was consistently superior to placebo with its particularly rapid onset action.

Nimesulide Tablets Use

Nimesulide is a popular NSAID prescribed for painful inflammatory conditions, back pain, dysmenorrhea associated with musculoskeletal system, Thrombophlebitis, dental pain and in ENT inflammation. 

Nimesulide is a prescription drug with important analgesic properties. Therefore it is always recommended to use this medicine under a licensed physician supervision and as per approved indications.

Nimesulide is available in various forms including tablets, suppositories, water-soluble powders, and topical gels. It is an analgesic and antipyretic in action.

Nimesulide Drug uses: 

• Nimesulide has less gastrointestinal adverse effects than other NSAIDs.
• It has superior benefit-risk ratio to other drugs with a comparable safety and tolerability to placebo.
• Rapid onset of action within 15 minutes
• Rapidly relieves pain in arthritis
• Its multifactorial mode of action gives it a unique and broad action on inflammatory.
• Nimesulide is also safe in sensitive asthmatic patients.
• It is reported to be beneficial in relieving the symptoms of rhinitis, rhinopharyngitis tubaritis and seceretory otitis media with concomitant antibiotic treatment.
• Nimesulide has potent analgesic, anti-inflammatory and antipyretic activities.

Nimesulide Tablet Uses

Nimesulide medication is a non-steroidal anti-inflammatory drug with analgesic and antyperetic properties, prescribed for painful inflammatory conditions, back pain, dysmenorrhea and etc.

The usual dosage of Nimesulide is 100mg twice a day. For children it should be taken 5mg/kg of body weight in 2 or 3 divided doses

Nimesulide is used to reduce:

1. Osteoarthritis
2. Low back Pain
3. Sports injury
4. Dental pain
5. Moderate pain & fever
6. Dysmenorrhea

Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.

Nimesulide is reported to be beneficial in relieving the symptoms of rhinitis, rhinopharyngitis tubaritis and seceretory otitis media with concomitant antibiotic treatment.

Precautions:

Women should use the drug with caution during lactation; Nimesulide is contraindicated during pregnancy.

Nimesulide Tablet Composition

Nimesulide is a Non steroidal anti inflammatory drug (NSAID) and targets COX-2 an enzyme responsible for inflammation & pain.

Nimesulide is used in the treatment of Osteoarthritis, Low back Pain, Sports injury, Dental pain, Moderate pain & fever, and Dysmenorrhea.

Uses of Nimesulide:

• Rapid onset of action within 15 minutes
• Rapidly relieves pain in arthritis

The nimesulide is preferably used in the composition in an amount of 0.1-5% by weight, more preferably in an amount of 0.1-3% by weight, most preferably in an amount of around 1 % by weight of the composition.

This medication is for the most part used as an issue of the treatment of inflammatory torment and also used for postoperative trauma, sports injuries, acute musculoskeletal disorders

Nimesulide Gel for pain relief

Nimesulide transdermal gel is a well endured novel hydroalcoholic microcarrier based drug delivery system with penetration enhancer. This is reason for predominant adequacy of Nimesulide Transdermal Gel and it is connected principally for topical agony administration.

Nimesulide is a non-steroidal mitigating( (NSAID) operators which have pain relieving properties. The product has been formed utilizing a novel mix of solvents for solubilization of Nimesulide.

Nimesulide gel is indicated for a variety of conditions portrayed by agony, aggravation and solidness, for example, osteoarthritis, periarthritis, post-traumatic or intense musculoskeletal issue including tendinitis, tenosynovitis, sprains, strains and low back torment. It Functions by restraining specific nerve motivations sent from the outskirts to your focal framework.

Nimesulide displayed better efficacy it likewise exhibited speedier onset of activity. Significant concentration of Nimesulide could be detected in the blood within 30 minutes of treatment and persisted for 8 hours post treatment

Nimesulide Tablet Solubility

Nimesulide NSAID’s tablet is an efficient and safe therapeutic selection for the treatment of assorted painful inflammatory conditions like inflammation, sore throat, stomatitis, arthritis, degenerative joint disease, low back pain etc., with a speedy onset of analgesic activity.

The quick dissolving tablets of Nimesulide contains superdisintegrants, that accelerates the disintegration of tablets by virtue of their ability to soak up great deal of water once exposed to binary compound surroundings.

Nimesulide is soluble in organic solvents like alcohol, DMSO, and dimethyl formamide (DMF).

Nimesulide is out there in varied forms like Nimesulide Tablets, Nimesulide Powder/granules, Nimesulide Gel, suppositories.

Clinical proved that it is available to support a particularly good profile in terms of gastrointestinal tolerability.

The employment of Nimesulide is usually recommended for the shortest length necessary to regulate symptoms in patients with acute pain or primary dysmenorrhoea.

Drug bank of Nimesulide medicine

Non-steroidal drug Nimesulide endorsed evidences are the treatment of intense agony, the symptomatic treatment of osteoarthritis and essential dysmenorrhoea, sports wounds and so on.

It has special properties of pain relieving and antipyretic which, specially inhibits the chemical cyclooxygenase-2 (COX-2) and has better gastro-intestinal tolerability.

It is utilized for treatment of different sorts of agonies coming about because of games harm, despondency and so on.

Dose:
Nimesulide is available with the dosage of 100mg its measurements ought to be taken by medicine of doctor and specialist which will help to take proper dosage for good come about.

Pharmacology:
Sustenance, sexual orientation and progressed age have insignificant impacts on nimesulide pharmacokinetics.

Uses:

• Analgesic and antipyretic.
• Rheumatoid arthritis, osteoarthritis, other degenerative joint disorders.
• Musculo skeletal disorders.
• Thrombophlebitis.

Nimesulide Drug Composition

Nimesulide, a wide recommended medication analgesic drug belongs to sulfonanilide class II and exhibit low and variable oral bioavailability.

Nimesulide (4-nitro-2-phenoxymethanesulfoanilide) is a selective Cox-2 anti-inflammatory drug. This compound, a by-product of p-nitrophenyl methane series sulfa, is structurally a singular non-steroidal anti-inflammatory drug.

It posses antihistaminic, analgesic and antipyretic properties.

NImesulide medication is used in the treatment for acute pain, symptomatic treatment of painful degenerative joint disease and first dysmenorrhoea.

It’s conjointly used for the treatment of skin-tone, Heart diseases, Cancer and dry skin. It likewise gives Quick and quick impacts with its rapid pain relief. It is also used for increasing energy

Forms of Nimesulide Tablet

Nimesuilde is a pain killer NSAIDs drug is the best prescribed drug for treatment of acute pain, Primary dysmennorhea and also to treat degenerative joint disease.

Nimesulide drug was launched in Italy for the first time as Aulin and Mesulid in 1985 and is presently available in more than 50 countries worldwide with different trademarks.

Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.

It has superior gastrointestinal safety as compared to other NSAIDs. It is an analgesic and antipyretic in action, other than its anti inflammatory action.

Unlike, other NSAIDs, the chemical structure of Nimesulide does not contain a carboxylic group but a sulfonanilide moiety as the acidic group.

Apart from tablet the drug- Nimesulide is also available in various forms such as in the form of Gell, powder, and suppositories. It’s also available in various brand names of Sulide, Nimalox, Nimesil, Nimulid, Nicip, Nimcap, Nise, Sulidene and Zolan e.t.c.

The Nimulid Transgel a brand from Nimesulide Transdermal Gel is indicated for post-traumatic inflammation, acute musculoskeletal disorders including sprains, strains, tendinitis, tenosynovitis, low back pain, periarthritis (shoulder pain) and osteoarthritis (joint pains), stiffness.

As with all drugs, therapy appropriateness when using Nimesulide is of out most importance to safeguard patient’s health and guarantee the product’s therapeutic value.

Nimesulide is available in the dosage of 100 mg for tablets, 100 mg for granules for oral suspension, 200mg for suppositories and 3% of gel. And the prescribed duration to use is for 15 days. 

Comparison of Suspension Composition of Nimesulide

Nimesulide is a non-steroidal anti-inflammatory agent that is widely used in the treatment of inflammatory pain.The efficacy and tolerability of nimesulide was consistently superior to placebo.

Nimesulide tablet undergoes extensive biotransformation and has a relatively rapid onset of action, with meaningful reductions in pain and inflammation observed within 15 minutes from drug intake.

The drug belongs to the class II of Biopharmaceutical Classification System (low solubility, high permeability) and therefore, absorption of this drug is limited by its dissolution.

Unlike, other NSAIDs, the chemical structure of nimesulide does not contain a carboxylic group but a sulfonanilide moiety as the acidic group.

Nimesulide is indicated in the treatment of a variety of painful inflammatory conditions including those associated with osteoarthritis, postoperative trauma, sports injuries, acute musculoskeletal disorders including tendonitis, tenosynovitis, sprains, strains and low back pain, ear, nose and throat disorders, dental surgery, bursitis/tendonitis, thrombophlebitis, pharyngitis and gynaecological disorders.