Nimesulide granules

Nimesulide Granules is non-steroidal anti-inflammatory drugs, indicated for the treatment of juvenile chronic arthritis, postoperative pain, acute pain after trauma and primary dysmenorrhea.

Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties.

Its approved indications are the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old.

Active ingredients: nimodipine. Indication: nimesulide granules is non-steroidal anti-inflammatory drugs, indicated for the treatment of juvenile chronic arthritis, postoperative pain, acute pain after trauma and primary dysmenorrhea.

Packaging: 1g / sack; 6, 8, 10 sacks / pack. Contact us for more information.

usage and consumption: oral, the goods only for adults only, a 50 mg to 100 mg daily twice postprandial taking. In accordance with the severity of the conditions and the needs of the patients can be increased to 0.2g, the second service.

elderly patients of the medication should strictly comply with the provisions of doctors. Doctors can reduce under appropriate in the circumstances listed above dosage.

Nimesulide Analgesic action and Antipyretic properties

Nimesulide Analgesic action and Antipyretic properties

Nimesulide drug for pain relief has a relatively rapid onset of the analgesic action for the patients suffering from acute pain which shows meaningful reductions observed within 15 minutes from drug intake.

Nimesulide is a prescription-only drug and must be prescribed by a licensed physician after careful evaluation of the patient’s characteristics and needs.
As per the recent evaluations on the safety profile of nimesulide confirms that nimesulide has a favourable benefit/risk profile in the approved indications.

Nimesulide shows multifactorial mode of action for the treatment of for post-traumatic inflammation, acute musculoskeletal disorders including sprains, strains, tendinitis, tenosynovitis, low back pain, periarthritis (shoulder pain) and osteoarthritis (joint pains), stiffness.

Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.

Nimesulide tablet has great analgesic and antipyretic properties which is nothing but relief from pain and reduction of body temperature.

The overall safety profile of nimesulide is in line with that of all other NSAIDs. As with all drugs, it must be used in the most appropriate way to guarantee its best therapeutic value.

As for other NSAIDs the use of Nimesulide is preffered for the shortest duration necessary to control symptoms in patients with acute pain or primary dysmenorrhoea. The efficacy of Nimesulide was consistently superior to placebo with its particularly rapid onset action.

Nimesulide Structure and its Uses

Nimesulide Structure and its Uses

Nimesulide is generally utilized as a part of the treatment of inflammatory torment which hinders the protein cyclooxygenase-2 (COX-2) and has better gastro-intestinal mediocrity in addition to different NSAIDs in its class.

Nimesulide (4-nitro-2-phenoxymethanesulfoanilide) This compound, a by-product of p-nitrophenyl methane series sulfa, is structurally a singular non-steroidal anti-inflammatory drug.

It is available in more than 50 countries worldwide.

Features: 

• Amongst most effective yet gastro friendly 
• Non steroidal anti inflammatory drug (NSAID) 
• Nimesulide targets COX-2 an enzyme responsible for inflammation & pain. 

Uses of Nimesulide:

• Nimesulide tablet has excellent gastrointestinal safety in comparison to other medication. 
• Rapid onset of action within 15 minutes 
• Rapidly relieves pain in arthritis

Indications:

• acute pain;
• primary dysmenorrhoea.

Nimesulide Structure and its Uses

Nimesulide is generally utilized as a part of the treatment of inflammatory torment which hinders the protein cyclooxygenase-2 (COX-2) and has better gastro-intestinal mediocrity in addition to different NSAIDs in its class.

Nimesulide (4-nitro-2-phenoxymethanesulfoanilide) This compound, a by-product of p-nitrophenyl methane series sulfa, is structurally a singular non-steroidal anti-inflammatory drug.

It is available in more than 50 countries worldwide.

Features: 

• Amongst most effective yet gastro friendly 
• Non steroidal anti inflammatory drug (NSAID) 
• Nimesulide targets COX-2 an enzyme responsible for inflammation & pain. 

Uses of Nimesulide:

• Nimesulide tablet has excellent gastrointestinal safety in comparison to other medication. 
• Rapid onset of action within 15 minutes 
• Rapidly relieves pain in arthritisIndications:
  • acute pain;
  • primary dysmenorrhoea.

Nimesulide Gel Uses

Nimesulide is available in the market in various forms including tablets (100 mg), granules for oral suspension (100 mg), suppositories (200 mg) and gel (3%).

Nimesulide Gel should be applied to the affected area, for 2 to 4 times every day.

Gel is used for the treatment of chronic and acute musculoskeletal disorders including discomfort in the muscles, tendonitis (cord), back pain/ache, arthritis, tenosynovitis(swelling in tendon) sprains, or strains.

Some patients were analysed for assessing the efficacy and safety of this gel. This studies results in better relief from pain and inflammation(redness/ swelling in a part of a body) parameters in more number of patients with Nimesulide Gel.

Nimesulide exhibited better efficacy, and demonstrated faster onset of action. Nimesulide provides significant analgesic (painrelief) activity when applied topically. Peak analgesic effect was observed at 120 min from treatment.

It functions by inhibiting particular nerve impulses sent from the periphery to your central system, leading to a decrease of sensitivity from the kinds of symptoms associated with the conditions above.

Nimesulide Drug Solubility

Nimesulide Drug Solubility

Nimesulide is a unique non- steroidal anti-inflammatory drug that acts specifically on cyclo-oxygenase-2 and does not affect cyclo-oxygenase-1. Hence, it exerts its anti-inflammatory action characteristics of non- steroidal anti-inflammatory drug. Solubility of Nimesulide Increased on solubilization of drug in semi-polar solvents and non-ionic surfactants.

Solubility of Nimesulide was studied using different cosolvent mixtures and various classes of non-ionic surfactant. Solubility increased drastically (>70 mg/rnl) when polyethylene glycol 300 and polyethylene glycol 400 were used as solvents.

The quick dissolving tablets of Nimesulide contains super that accelerates the disintegration of tablets by virtue of their ability to soak up great deal of water once exposed to binary compound surroundings.

Nimesulide is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, Nimesulide should first be dissolved in ethanol and then diluted with the aqueous buffer of choice. Nimesulide has a solubility of approximately <200 μg/ml in a 10% DMSO in PBS (pH 7.2) solution using this method.

Nimesulide BP 100mg

Nimesulide BP 100mg

Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory pain killer drug(NSAID) prescribed for treatment of acute pain, Primary dysmennorhea and degenerative joint disease.

This medicine has potent analgesic, anti pyretic and anti-inflammatory activity on oral & rectal administration.

Nimesulide BP 100mg prevents the release of prostaglandins which is responsible for inflammation, pain & fever.

Nimesulide is a selective inhibitor of prostaglandin synthesis but appears to exert its therapeutic effect by a variety of other mechanisms like inhibition of platelet-activating factor (PAF), tumour necrosis factor-alpha (TNF alpha,) Proteinase & histamine etc.

Nimesulide is Indicated in reducing pain, fever and inflammatory symptoms of:

• Chronic arthritis
• Osteo arthritis
• Otorhinolary diseases
• Soft tissues and oral cavity inflammation
• Dysmenorrhoea
• Thrombosis
• Urogenital disease
• Postoperative pain states
• Sports injuries

Nimesulide BP

Nimesulide BP 100mg

Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory pain killer drug(NSAID) prescribed for treatment of acute pain, Primary dysmennorhea and degenerative joint disease.

This medicine has potent analgesic, anti pyretic and anti-inflammatory activity on oral & rectal administration.

Nimesulide BP 100mg prevents the release of prostaglandins which is responsible for inflammation, pain & fever.

Nimesulide is a selective inhibitor of prostaglandin synthesis but appears to exert its therapeutic effect by a variety of other mechanisms like inhibition of platelet-activating factor (PAF), tumour necrosis factor-alpha (TNF alpha,) Proteinase & histamine etc.

Nimesulide is Indicated in reducing pain, fever and inflammatory symptoms of:

• Chronic arthritis
• Osteo arthritis
• Otorhinolary diseases
• Soft tissues and oral cavity inflammation
• Dysmenorrhoea
• Thrombosis
• Urogenital disease
• Postoperative pain states
• Sports injuries

Nimesulide Analgesic action and Antipyretic properties

Nimesulide Analgesic action and Antipyretic properties

Nimesulide drug for pain relief has a relatively rapid onset of the analgesic action for the patients suffering from acute pain which shows meaningful reductions observed within 15 minutes from drug intake.

Nimesulide is a prescription-only drug and must be prescribed by a licensed physician after careful evaluation of the patient’s characteristics and needs.
As per the recent evaluations on the safety profile of nimesulide confirms that nimesulide has a favourable benefit/risk profile in the approved indications.

Nimesulide shows multifactorial mode of action for the treatment of for post-traumatic inflammation, acute musculoskeletal disorders including sprains, strains, tendinitis, tenosynovitis, low back pain, periarthritis (shoulder pain) and osteoarthritis (joint pains), stiffness.

Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.

Nimesulide tablet has great analgesic and antipyretic properties which is nothing but relief from pain and reduction of body temperature.

The overall safety profile of nimesulide is in line with that of all other NSAIDs. As with all drugs, it must be used in the most appropriate way to guarantee its best therapeutic value.

As for other NSAIDs the use of Nimesulide is preffered for the shortest duration necessary to control symptoms in patients with acute pain or primary dysmenorrhoea. The efficacy of Nimesulide was consistently superior to placebo with its particularly rapid onset action.

Nimesulide 100mg Tablet

Nimesulide 100mg Therapeutic indications:

• Treatment of acute pain
• Symptomatic treatment of painful osteoarthritis (pain and swelling of joints)
• Primary dysmenorrhoea.

Nimesulide is available in the market in various forms including tablets (100 mg), granules for oral suspension (100 mg), suppositories (200 mg) and gel (3%).

How It Works:

Nimesulide belongs to a class of medications called non-steroidal anti-inflammatory drugs (NSAIDs) which works by blocking the production of prostaglandins (a chemical associated with pain) thereby relieving pain and inflammation.

The maximum duration of a treatment course with Nimesulide is 15 days. Nimesulide 100mg Tablets/granules should be used for the shortest possible duration.

Nimesulide 100mg is Indicated in reducing pain, fever and inflammatory symptoms of:

• Chronic arthritis (long-term disease)
• Osteo arthritis (joint-pains)
• Otorhinolary diseases (ear, nose and throat)
• Soft tissues and oral cavity inflammation
• Dysmenorrhoea (period pains)
• Thrombosis (clotting of blood in circulatory system)
• Urogenital disease (urinary and genital organs.)
• Postoperative pain states (pain after surgery)
• Sports injuries

Nimesulide 100mg is also proved to be safe in asthmatic patients. It is reported to be beneficial in relieving the symptoms of rhinitis (inflammation of mucous membrane inside nose), cold.

Nimesulide Tablet Uses

Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) which means it provides analgesic (pain-killing) and antipyretic(fever-reducing) effects. Nimesulide is mostly used for treatment of short-term pain(Acute), joint pain (osteoarthritis), period pains (Primary dysmennorhea), Chronic pains and many.

Acute Pain: starts suddenly and usually feels sharp. Broken bones, burns, or cuts are examples of acute pain. Acute pain lasts just a moment or it may last for weeks or months. Some times it may also lead to Chronic pain (long-term pain).

Ex of Chronic pains:

• Headache
• Low back pain
• Cancer pain
• Arthritis pain
• Pain caused by nerve damage

Nimesulide shows positive reaction in the treatment of several painful situations with an acute inflammatory component including primary dysmenorrhea because of the rapid onset of the analgesic action. which Nimesulide shows meaningful reductions observed within 15 minutes from drug intake.

Osteoarthritis: It is most common in middle-aged and older people, and its symptoms can range from very mild to very severe it mostly affects hands and weight-bearing joints such as Knees, hips, feet and the back, but can affect almost any joint in the body.

Joint pains mostly caused due to Obesity, Injury, Heridity, Joint overuse(Over use of any joint like repeated bending of knees), and most common cause is Age.

Nimesulide ease pain and make it favorable in the treatment of joint diseases. A clinical study has been carried out with patients suffering from join pains. This study has proved efficacy and tolerability in patients.

Primary dysmennorhea: It shows pain in lower abdomen which is very common problem in young women (occurring in the absence of pelvic pathology).

Nimesulide is useful in the treatment of pain associated with primary dysmenorrhea. Nimesulide alleviates pain within 30 min. The drug changes the painful state of uterine contracture to painless cyclic contractions.

Nimesulide uses

NSAIDs drug Nimesulide has proven benefits in the treatment of Acute (short term) pain, Painful osteoarthritis (Swelling in the joints) and Primary dysmennorhea ( Period Pains)

Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.

The tablet has superior gastrointestinal safety as compared to other NSAIDs

Apart from Tablet NImesulide is also available in the form of powder, gel, suppositories, mouth dissolving tablets.

Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) which means it provides analgesic (pain-killing) and antipyretic(fever-reducing) effects. Nimesulide is mostly used for treatment of short-term pain(Acute), joint pain (osteoarthritis), period pains (Primary dysmennorhea), Chronic pains and many.

Acute Pain: starts suddenly and usually feels sharp. Broken bones, burns, or cuts are examples of acute pain. Acute pain lasts just a moment or it may last for weeks or months. Some times it may also lead to Chronic pain (long-term pain)

Eg of Chronic pains:

• Headache
• Low back pain
• Cancer pain
• Arthritis pain
• Pain caused by nerve damage

Nimesulide shows positve reaction in the treatment of several painful situations with an acute inflammatory component including primary dysmenorrhea because of the rapid onset of the analgesic action. which Nimesulide shows meaningful reductions observed within 15 minutes from drug intake.Osteoarthritis: It is most common in middle-aged and older people, and its symptoms can range from very mild to very severe it mostly affects hands and weight-bearing joints such as Knees, hips, feet and the back, but can affect almost any joint in the body.

Nimesulide Gel System for Topical Use

Nimesulide is a known Anti inflamatory agent whose therapeutical efficacy has been proved for acute Acute pain relief and Primary dysmennorhea and and also to treat degenerative joint disease

Nimesulide is available in various forms like Gel, Powder, etc. Nimesulide Gel is used to treat chronic and acute musculoskeletal disorders such as soft tissue injuries or non-articular rheumatic disorders, including discomfort in the muscles, tendonitis, back pain/ache, arthritis, tenosynovitis sprains, or strains. The onset of pain relief was normally observed within 15-60 minutes.

Nimesulide transdermal gel was statistically more significant in reducing the mean scores of pain intensity

Nimesulide is available in assortment of structures like as tablets and syrup for oral organization and gels for topical application.

The anti-inflammatory activity of topically applied Nimesulide gel demonstrations particularly on cyclo-oxygenase-2 which applies less gastrointestinal antagonistic impacts than different NSAIDs.

Nimesulide Analgesic action and Antipyretic properties

Nimesulide drug for pain relief has a relatively rapid onset of the analgesic action for the patients suffering from acute pain which shows meaningful reductions observed within 15 minutes from drug intake.

Nimesulide is a prescription-only drug and must be prescribed by a licensed physician after careful evaluation of the patient’s characteristics and needs.
As per the recent evaluations on the safety profile of nimesulide confirms that nimesulide has a favourable benefit/risk profile in the approved indications.

Nimesulide shows multifactorial mode of action for the treatment of for post-traumatic inflammation, acute musculoskeletal disorders including sprains, strains, tendinitis, tenosynovitis, low back pain, periarthritis (shoulder pain) and osteoarthritis (joint pains), stiffness.

Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.

Nimesulide tablet has great analgesic and antipyretic properties which is nothing but relief from pain and reduction of body temperature.

The overall safety profile of nimesulide is in line with that of all other NSAIDs. As with all drugs, it must be used in the most appropriate way to guarantee its best therapeutic value.

As for other NSAIDs the use of Nimesulide is preffered for the shortest duration necessary to control symptoms in patients with acute pain or primary dysmenorrhoea. The efficacy of Nimesulide was consistently superior to placebo with its particularly rapid onset action.

Nimesulide Analgesic action and Antipyretic properties

Nimesulide drug for pain relief has a relatively rapid onset of the analgesic action for the patients suffering from acute pain which shows meaningful reductions observed within 15 minutes from drug intake.

Nimesulide is a prescription-only drug and must be prescribed by a licensed physician after careful evaluation of the patient’s characteristics and needs.

As per the recent evaluations on the safety profile of nimesulide confirms that nimesulide has a favourable benefit/risk profile in the approved indications.

Nimesulide shows multifactorial mode of action for the treatment of for post-traumatic inflammation, acute musculoskeletal disorders including sprains, strains, tendinitis, tenosynovitis, low back pain, periarthritis (shoulder pain) and osteoarthritis (joint pains), stiffness.

Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.

Nimesulide tablet has great analgesic and antipyretic properties which is nothing but relief from pain and reduction of body temperature.

The overall safety profile of nimesulide is in line with that of all other NSAIDs. As with all drugs, it must be used in the most appropriate way to guarantee its best therapeutic value.

As for other NSAIDs the use of Nimesulide is preffered for the shortest duration necessary to control symptoms in patients with acute pain or primary dysmenorrhoea. The efficacy of Nimesulide was consistently superior to placebo with its particularly rapid onset action.

Nimesulide Structure and its Uses

Nimesulide is generally utilized as a part of the treatment of inflammatory torment which hinders the protein cyclooxygenase-2 (COX-2) and has better gastro-intestinal mediocrity in addition to different NSAIDs in its class.

Nimesulide (4-nitro-2-phenoxymethanesulfoanilide) This compound, a by-product of p-nitrophenyl methane series sulfa, is structurally a singular non-steroidal anti-inflammatory drug.

It is available in more than 50 countries worldwide.

Features:

• Amongst most effective yet gastro friendly 
• Non steroidal anti inflammatory drug (NSAID) 
• Nimesulide targets COX-2 an enzyme responsible for inflammation & pain. 

Uses of Nimesulide:

• Nimesulide tablet has excellent gastrointestinal safety in comparison to other medication. 
• Rapid onset of action within 15 minutes 
• Rapidly relieves pain in arthritis

Indications:

• acute pain;
• primary dysmenorrhoea.

Nimesulide Tablet Uses

Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) which acts as a cyclooxygenase- 2 inhibitor. It has become a leading NSAID in over 50 countries worldwide.

Nimesulide tablet is used for the treatment of osteoarthritis, postoperative trauma, sports injuries, acute musculoskeletal disorders including tendonitis, tenosynovitis, sprains, strains and low back pain, ear, nose and throat disorders

Usage of Nimesulide 100mg- Tablet:

• Nimesulide has less gastrointestinal adverse effects than other NSAIDs 
• It has superior benefit-risk ratio to other drugs with a comparable safety and tolerability to placebo.
• Its multifactorial mode of action gives it a unique and broad action on inflammatory. 
• Nimesulide is also safe in sensitive asthmatic patients. It is reported to be beneficial in relieving the symptoms of rhinitis, rhinopharyngitis tubaritis and seceretory otitis media with concomitant antibiotic treatment. 
• Nimesulide has potent analgesic, anti-inflammatory and antipyretic activities
• Nimesulide tablet undergoes extensive biotransformation and has a relatively rapid onset of action, with meaningful reductions in pain and inflammation observed within 15 minutes from drug intake.

Its an anti-inflammatory with analgesic and antipyretic activity. It is also has low gastro-intestinal and renal toxicity.

Drug bank of Nimesulide medicine

Non-steroidal drug Nimesulide endorsed evidences are the treatment of intense agony, the symptomatic treatment of osteoarthritis and essential dysmenorrhoea, sports wounds and so on.

It has special properties of pain relieving and antipyretic which, specially inhibits the chemical cyclooxygenase-2 (COX-2) and has better gastro-intestinal tolerability.

It is utilized for treatment of different sorts of agonies coming about because of games harm, despondency and so on.

Dose:
Nimesulide is available with the dosage of 100mg its measurements ought to be taken by medicine of doctor and specialist which will help to take proper dosage for good come about.

Pharmacology:
Sustenance, sexual orientation and progressed age have insignificant impacts on nimesulide pharmacokinetics.

Uses:

• Analgesic and antipyretic.
• Rheumatoid arthritis, osteoarthritis, other degenerative joint disorders.
• Musculo skeletal disorders.
• Thrombophlebitis.