Nise tablet for pain relief

Nise tablet for pain relief

"Nise" tablet is a trademark for the drug "Nimesulide" which is a Non-steroidal medicinal drug (NSAIDs). Nise medicine is used for the treatment of acute pain, symptomatic relief of osteoarthritis (degradation of joints) and primary dysmenorrhoea.

NImesulide is available around 50 countries with different trademarks such as Sulide, Nimalox, Nimesil, Nimulid, Nicip, Nimcap, Nise, Sulidene and Zolane etc.

Nise is a relatively COX-2 selective with analgesic and antipyretic properties.

Nise helps in relieve in pain and inflammation. It has multifactorial mode of action and is characterized by a fast onset of analgesic action.

NIse is also available in the form of gel. It has superior gastrointestinal safety as compared to other NSAIDs. Nise tablet is prescribed for the age above 12 years.

It must be used under supervision by a doctor in accordance with the approved indications and in compliance with the recommendations. tablet for pain relief

"Nise" tablet is a trademark for the drug "Nimesulide" which is a Non-steroidal medicinal drug (NSAIDs). Nise medicine is used for the treatment of acute pain, symptomatic relief of osteoarthritis (degradation of joints) and primary dysmenorrhoea.

NImesulide is available around 50 countries with different trademarks such as Sulide, Nimalox, Nimesil, Nimulid, Nicip, Nimcap, Nise, Sulidene and Zolane etc.

Nise is a relatively COX-2 selective with analgesic and antipyretic properties.

Nise helps in relieve in pain and inflammation. It has multifactorial mode of action and is characterized by a fast onset of analgesic action.

NIse is also available in the form of gel. It has superior gastrointestinal safety as compared to other NSAIDs. Nise tablet is prescribed for the age above 12 years.

It must be used under supervision by a doctor in accordance with the approved indications and in compliance with the recommendations.

Nimesulide Brands

Nimesulide is a non-steroidal anti-inflammatory analgesic and antipyretic drug (NSAID). It is a selective cyclooxygenase - 2 (COX -2) enzyme inhibitor and is effective in the treatment of a wide range of inflammatory and painful conditions including osteoarthritis, extra-curricular disorders such as tendonitis and bursitis, post-operative pain and primary dysmenorrhoea.

Nimesulide gel preparations for localized topical application are indicated for the treatment of symptomatic relief of pain associated with sprains and acute traumatic tendinitis.

The most powerfull painkiller NSAIDs tablet Nimesulide is been available since 1985 and authorised in worldwide over 50 countries.

It has superior gastrointestinal safety as compared to other NSAIDs.

It is available in various forms apart from tablets such as in the form of Gell, powder, and suppositories. It’s also available in several trademarks.

Nimesulide brands such as Sulide, Nimalox, Nimesil, Nimulid, Nicip, Nimcap, Nise, Sulidene and Zolan.
Nimulid is also obtaining in the form of gel.

The Nimulid Transgel a brand from Nimesulide Transdermal Gel is indicated for post-traumatic inflammation, acute musculoskeletal disorders including sprains, strains, tendinitis, tenosynovitis, low back pain, periarthritis (shoulder pain) and osteoarthritis (joint pains), stiffness.

Nimesulide Medicine for Osteoarthritis

Nimesulide Medicine for Osteoarthritis

Nimesulide drug was launched in Italy for the first time as Aulin and Mesulid in 1985 and is presently available in more than 50 countries worldwide with different trademarks.

Nimesulide is used for the treatment of post-traumatic inflammation, acute musculoskeletal disorders including sprains, strains, tendinitis, tenosynovitis, low back pain, periarthritis (shoulder pain) and osteoarthritis (joint pains), stiffness.

Nimesulide brands such as Sulide, Nimalox, Nimesil, Nimulid, Nicip, Nimcap, Nise, Sulidene and Zolan

It has superior gastrointestinal safety as compared to other NSAIDs.

It is an analgesic and antipyretic in action. Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.

The maximum duration and dose of a treatment course with Nimesulide medicine is 15 days, 100 mg twice a day, to minimize the risk of hepatotoxicity.

Nimesulide Drug Solubility

Nimesulide Drug Solubility

Nimesulide is a unique non- steroidal anti-inflammatory drug that acts specifically on cyclo-oxygenase-2 and does not affect cyclo-oxygenase-1. Hence, it exerts its anti-inflammatory action characteristics of non- steroidal anti-inflammatory drug. Solubility of Nimesulide Increased on solubilization of drug in semi-polar solvents and non-ionic surfactants.

Solubility of Nimesulide was studied using different cosolvent mixtures and various classes of non-ionic surfactant. Solubility increased drastically (>70 mg/rnl) when polyethylene glycol 300 and polyethylene glycol 400 were used as solvents.

The quick dissolving tablets of Nimesulide contains super that accelerates the disintegration of tablets by virtue of their ability to soak up great deal of water once exposed to binary compound surroundings.

Nimesulide is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, Nimesulide should first be dissolved in ethanol and then diluted with the aqueous buffer of choice. Nimesulide has a solubility of approximately <200 μg/ml in a 10% DMSO in PBS (pH 7.2) solution using this method.

Nimesulide Medicine

Nimesulide Medicine

Nimesulide 100mg Therapeutic indications:

• Treatment of acute pain
• Symptomatic treatment of painful osteoarthritis
• Primary dysmenorrhoea.

Nimesulide Medicine uses:

• Nimesulide has less gastrointestinal adverse effects than other NSAIDs
• It has superior benefit-risk ratio to other drugs with a comparable safety and tolerability to placebo.
• Its multifactorial mode of action gives it a unique and broad action on inflammatory.
• Nimesulide is also safe in sensitive asthmatic patients. It is reported to be beneficial in relieving the symptoms of rhinitis, rhinopharyngitis tubaritis and seceretory otitis media with concomitant antibiotic treatment.
• Nimesulide has potent analgesic, anti-inflammatory and antipyretic activities

Nimesulide medicines are recommended for short duration of 15days

Nimesulide Tablets use

Nimesulide Tablets Use

Nimesuilde is a pain killer NSAIDs drug best prescribed drug for treatment of acute pain, Primary dysmennorhea and also to treat degenerative joint disease.

Nimesulide is indicated in the treatment of a variety of painful inflammatory conditions including those associated with Osteoarthritis, Postoperative trauma, Sports injuries, Ear, Nose and Throat disorders, Dental surgery, Bursitis/Tendinitis, Thrombhophlebitis, Pharyngitis and Gynaecological disorders.

Nimesulide is a prescription drug with important analgesic properties. Therefore it is always recommended to use this medicine under a licensed physician supervision and as per approved indications.

Nimesulide Tablet is also used for:

• Rapid onset of action within 15 minutes
• Nimesulide has less gastrointestinal adverse effects than other NSAIDs.

Nimesulide tablet for joint pain relief

Nimesulide Medicine for Joint pain treatment

Joint ache influenced by osteoarthritis (OA) which is a gathering of mechanical abnormailities including debasement of joints, and NSAID’s – Nimesulide is most regularly used to treat agony connected with OA.

The primary symptom is agony, creating loss of capacity and regularly solidness. Osteoarthritis (OA) is brought about by aging joints, damage, and obesity. OA usually influences the hands, feet, spine, and the expansive weight bearing joints, for example, the hips and knees.


Nimesulide proved to be significantly more viable in giving symptomatic relief. Nimesulide speaks to a successful operator for the treatment of joint ache, with specific reference to the quick onset of its pain relieving impact.

It additionally utilized for the treatment of primary Dysmenorrhea, and Acute ache.

Nimesulide shows significant diminishments in pain and irritation observed in 15 minutes with pain relieving and antipyretic properties.

Nimesulide Synthesis

Nimesulide Drug Synthesis

Nimesulide is a non-steroidal anti-inflammatory agent that is generally utilized as a part of the treatment of inflammatory torment which hinders the protein cyclooxygenase-2 (COX-2) and has better gastro-intestinal mediocrity in addition to different NSAIDs in its class.

Its approved signs are the treatment of intense torment, the symptomatic treatment of osteoarthritis and essential dysmenorrhoea, sports wounds and so on.

A variety of new Nimesulide derivatives were synthesized through incorporation of a 5-LOX pharmacophore into nimesulide followed with some structural modifications, which were then characterized for dual enzyme inhibitors for these two types of enzymes (Cyclooxygenase-½ (COX-½) and 5-lipoxygenase (5-LOX) ). Their structure-activity relationships (SARs) were studied, and compound 20f was found to be an excellent dual enzyme inhibitor.

Its binding conformation and interaction mode were studied with molecular docking experiments. Compound 20f could become a lead compound for further development for potential anti-inflammatory drugs.

Clinically it has demonstrated that it supports an especially good profile as far as gastrointestinal tolerability.

Nimesulide Gel

Nimesulide Gel Uses

Standard

Nimesulide is available in various forms including tablets, suppositories, water-soluble powders, and topical gels.

Original Nimesulide is commercially available as tablets (100 mg), granules for oral suspension (100 mg), suppositories (200 mg) and gel (3%).


Nimesulide Gel (Nimesulide/Methyl Salicylate/Menthol/Capsaicin) is used to treat chronic and acute musculoskeletal disorders such as soft tissue injuries or non-articular rheumatic disorders, including discomfort in the muscles, tendonitis, back pain/ache, arthritis, tenosynovitis sprains, or strains.


Dosage and Administration
Nimesulide Gel is apply to the affected area, rubbing in a thin layer of the gel 2 to 4 times every day. For best results, wash the application area beforehand to clean away any oil, grease, or bacteria, allowing the gel to absorb more easily.


Nimesulide is available in assortment of structures like as tablets and syrup for oral organization and gels for topical application.


The anti-inflammatory activity of topically applied Nimesulide gel demonstrations particularly on cyclo-oxygenase-2 which applies less gastrointestinal antagonistic impacts than different NSAIDs.

Nimesulide BP

Nimesulide BP

Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory pain killer drug(NSAID) prescribed for treatment of acute pain, Primary dysmennorhea and degenerative joint disease.

This medicine has potent analgesic, anti pyretic and anti-inflammatory activity on oral & rectal administration.

Nimesulide BP 100mg prevents the release of prostaglandins which is responsible for inflammation, pain & fever.

Nimesulide is a selective inhibitor of prostaglandin synthesis but appears to exert its therapeutic effect by a variety of other mechanisms like inhibition of platelet-activating factor (PAF), tumour necrosis factor-alpha (TNF alpha,) Proteinase & histamine etc.

 Nimesulide is Indicated in reducing pain, fever and inflammatory symptoms of:

• Chronic arthritis
• Osteo arthritis
• Otorhinolary diseases
• Soft tissues and oral cavity inflammation
• Dysmenorrhoea
• Thrombosis
• Urogenital disease
• Postoperative pain states
• Sports injuries

Nimesulide BP

Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory pain killer drug(NSAID) prescribed for treatment of acute pain, Primary dysmennorhea and degenerative joint disease.

This medicine has potent analgesic, anti pyretic and anti-inflammatory activity on oral & rectal administration.

Nimesulide BP 100mg prevents the release of prostaglandins which is responsible for inflammation, pain & fever.

Nimesulide is a selective inhibitor of prostaglandin synthesis but appears to exert its therapeutic effect by a variety of other mechanisms like inhibition of platelet-activating factor (PAF), tumour necrosis factor-alpha (TNF alpha,) Proteinase & histamine etc.

Nimesulide is Indicated in reducing pain, fever and inflammatory symptoms of:

• Chronic arthritis
• Osteo arthritis
• Otorhinolary diseases
• Soft tissues and oral cavity inflammation
• Dysmenorrhoea
• Thrombosis
• Urogenital disease
• Postoperative pain states
• Sports injuries

Nimesulide Tablet Efiicacy

The abilities of NSAID’s drug Nimesulide to inhibit COX-2 preferentially and to exert other novel anti-inflammatory actions are consistent with good efficacy and safety with highly effective in reducing pain, inflammation and also helps in better penetration of the antibiotics.

Nimesulide posses analgesic properties with multifactorial mode of action for the treatment of musculoskeletal system, dysmenorrhoea, and acute pain.

It also undergoes extensive biotransformation. The recent study on the basis of analgesic activity of Nimesulide has proved that it has a quicker onset which shows relief from pain relief and inflammation within 15 minutes from drug intake.

Nimesulide is recommended for the shortest duration necessary to control symptoms in patients with acute pain or primary dysmenorrhoea.

Nimesulide Medicine for Joint pain treatment

Joint ache influenced by osteoarthritis (OA) which is a gathering of mechanical abnormailities including debasement of joints, and NSAID’s – Nimesulide is most regularly used to treat agony connected with OA.

The primary symptom is agony, creating loss of capacity and regularly solidness. Osteoarthritis (OA) is brought about by aging joints, damage, and obesity. OA usually influences the hands, feet, spine, and the expansive weight bearing joints, for example, the hips and knees.


Nimesulide proved to be significantly more viable in giving symptomatic relief. Nimesulide speaks to a successful operator for the treatment of joint ache, with specific reference to the quick onset of its pain relieving impact.

It additionally utilized for the treatment of primary Dysmenorrhea, and Acute ache.

Nimesulide shows significant diminishments in pain and irritation observed in 15 minutes with pain relieving and antipyretic properties.

Nimesulide Medicine

Nimesulide 100mg Therapeutic indications:

• Treatment of acute pain
• Symptomatic treatment of painful osteoarthritis
• Primary dysmenorrhoea.

Nimesulide Medicine uses:

• Nimesulide has less gastrointestinal adverse effects than other NSAIDs
• It has superior benefit-risk ratio to other drugs with a comparable safety and tolerability to placebo.
• Its multifactorial mode of action gives it a unique and broad action on inflammatory.
• Nimesulide is also safe in sensitive asthmatic patients. It is reported to be beneficial in relieving the symptoms of rhinitis, rhinopharyngitis tubaritis and seceretory otitis media with concomitant antibiotic treatment.
• Nimesulide has potent analgesic, anti-inflammatory and antipyretic activities

Nimesulide medicines are recommended for short duration of 15days

Nimesulide Tablets

Features:

• Amongst most effective yet gastro friendly
• Non steroidal anti inflammatory drug (NSAID)
• Nimesulide targets COX-2 an enzyme responsible for inflammation & pain.

Indications:

• Osteoarthritis
• Low back Pain
• Sports injury
• Dental pain
• Moderate pain & fever
• Dysmenorrhea

Uses of Nimesulide:Offered tablet has excellent gastrointestinal safety in comparison to other medication.

• Rapid onset of action within 15 minutes
• Rapidly relieves pain in arthritis

Nimesulide Offered tablet has excellent gastrointestinal safety in comparison to other medication.

Nimesulide Painkiller Drug

Nimesulide is used in giving relief from acute pain associated with rheumatoid arthritis, osteoarthritis and primary dysmenorrhoea in adolescents and adults.

The drug is also an effective antipyretic and used to treat headaches and flu. It is also used in treating inflammatory conditions in humans and pain caused by arthritis or severe injury.

Nimesulide is a popular NSAID and available in various forms including tablets, suppositories, water-soluble powders, and topical gels.

Working of Nimesulide

It acts by inhibiting the release of tumour necrosis factor-alpha, acts as a competitive inhibitor of histamine release and reduces superoxide anion formation

Nimesulide Dosage

Adults: 100 mg twice daily
Children: 5mg/kg of body weight in 2 or 3 divided doses.

Nimesulide Efficacy

The abilities of NSAID’s drug nimesulide to inhibit COX-2 preferentially and to exert other novel anti-inflammatory actions are consistent with good efficacy and safety with highly effective in reducing pain, inflammation and also helps in better penetration of the antibiotics.

Nimesulide posses analgesic properties with multifactorial mode of action for the treatment of musculoskeletal system, dysmenorrhoea, and acute pain .

It also undergoes extensive biotransformation. The recent study on the basis of analgesic activity of nimesulide has proved that Nimesulide had a quicker onset which shows relief from pain relief and inflammation within 15 minutes from drug intake.

Nimesulide is recommended for the shortest duration necessary to control symptoms in patients with acute pain or primary dysmenorrhoea.

Nimesulide 100mg Medicine

Non-steroidal anti-inflammatory drug Nimesulide, prescribed for painful inflammatory conditions, back pain, dysmenorrhea, postoperative pain, osteoarthritis, and fever.

 

Nimesulide is also indicated in painful inflammatory conditions associated with musculoskeletal system, dysmenorrhoea, Thrombophlebitis, dental pain and in ENT inflammation.

 

Usage of Nimesulide 100mg- Tablet:

• Analgesic and antipyretic.
• Rheumatoid arthritis, osteoarthritis, other degenerative joint disorders.
• Musculo skeletal disorders.
• Thrombophlebitis.

Nimesulide tablet has great analgesic and antipyretic properties which is nothing but relief from pain and reduction of body temperature.

Nimesulide should be used only with the medical prescription. A prescription can be considered appropriate when it is in accordance with the approved indications of a drug in terms of demonstrated efficacy, dosage, and treatment duration.

Nimesulide Tablet Formulation

Nimesulide, a widely prescribed anti-inflammatory analgesic drug belongs to BCS class II and exhibit low and variable oral bioavailability.

 

Nimesulide (4-nitro-2-phenoxymethanesulfoanilide) may be a particular Cox-2 anti-inflammatory medication. This compund, a by-result of p-nitrophenyl methane arrangement sulfa, is structurally a solitary non-steroidal anti-inflammatorydrug. It has a place with particular COX-2inhibitors, with an intense pain relieving movement.

its shown as second line treatment for  acute pain, symptomatic treatment of excruciating degenerative joint ailment and first dysmenorrhoea.

Nimesulide tablet incorporates:

• Fast results
• Helpful and supportive
• No feature impacts
• Fast and quick effects

Nimesulide Tablet Advantages:

• Nimesulide has less gastrointestinal adverse effects than other NSAIDs
• It has superior benefit-risk ratio to other drugs with a comparable safety and tolerability to placebo.
• Its multifactorial mode of action gives it a unique and broad action on inflammatory.
• Nimesulide is also safe in sensitive asthmatic patients. It is reported to be beneficial in relieving the symptoms of rhinitis, rhinopharyngitis tubaritis and seceretory otitis media with concomitant antibiotic treatment. 
• Nimesulide has potent analgesic, anti-inflammatory and antipyretic activities

Nimesulide Tablet Brands

NSAID’s tablet Nimesulide is been available since 1985 and sanction with assorted trade names in worldwide in abundance of 50 countries.

Main purpose of using Nimesulide drug is to:

• Treat exceptional torment from degenerative joint disease.
• Treat crucial dysmenorrhoea in youngsters and  adults in excess of 12 years old.
• Treat various sorts of torments coming to fruition as a result of recreations harm, dejection and so forth.
• Treat Cancer
• Treat dry skin

Nimesulide is available in distinctive brands, for instance, Sulide, Nimalox, Nimesil, Nimulid, Nicip, Nimcap, Nise, Sulidene and Zolan.

Nimulid is used for post-traumatic irritation, extreme musculoskeletal issue including sprains, strains, tendinitis, tenosynovitis, low spinal pain, periarthritis (shoulder anguish) and osteoarthritis (joint torments), immovability.

Nise (100 mg) – Tablet, contains Generic Medicine Nimesulide- 100 mg. which is a non-steroidal alleviating drug