Nimesulide Tablet Formulation

Nimesulide, a widely prescribed anti-inflammatory analgesic drug belongs to BCS class II and exhibit low and variable oral bioavailability.

 

Nimesulide (4-nitro-2-phenoxymethanesulfoanilide) may be a particular Cox-2 anti-inflammatory medication. This compund, a by-result of p-nitrophenyl methane arrangement sulfa, is structurally a solitary non-steroidal anti-inflammatorydrug. It has a place with particular COX-2inhibitors, with an intense pain relieving movement.

its shown as second line treatment for  acute pain, symptomatic treatment of excruciating degenerative joint ailment and first dysmenorrhoea.

Nimesulide tablet incorporates:

• Fast results
• Helpful and supportive
• No feature impacts
• Fast and quick effects

Nimesulide Tablet Advantages:

• Nimesulide has less gastrointestinal adverse effects than other NSAIDs
• It has superior benefit-risk ratio to other drugs with a comparable safety and tolerability to placebo.
• Its multifactorial mode of action gives it a unique and broad action on inflammatory.
• Nimesulide is also safe in sensitive asthmatic patients. It is reported to be beneficial in relieving the symptoms of rhinitis, rhinopharyngitis tubaritis and seceretory otitis media with concomitant antibiotic treatment. 
• Nimesulide has potent analgesic, anti-inflammatory and antipyretic activities

Nimesulide Tablet Composition

Nimesulide is a Non steroidal anti inflammatory drug (NSAID) and targets COX-2 an enzyme responsible for inflammation & pain.

Nimesulide is used in the treatment of Osteoarthritis, Low back Pain, Sports injury, Dental pain, Moderate pain & fever, and Dysmenorrhea.

Uses of Nimesulide:

• Rapid onset of action within 15 minutes
• Rapidly relieves pain in arthritis

The nimesulide is preferably used in the composition in an amount of 0.1-5% by weight, more preferably in an amount of 0.1-3% by weight, most preferably in an amount of around 1 % by weight of the composition.

This medication is for the most part used as an issue of the treatment of inflammatory torment and also used for postoperative trauma, sports injuries, acute musculoskeletal disorders

Nimesulide Drug Uses

Pharmacokinetic:

Nimesulide has a potent Anti-Inflammatory action.It behaves as a competetive inhibitor of histamine release in-vivo and in-vitro, hence posseses antihistaminic and antiallergic properties.

Indications:

Nimesulide is indicated in painful inflammatory conditions associated with musculoskeletal system, dysmenorrhoea, Thrombophlebitis, dental pain and in ENT inflammation.

Absorption:

Well absorbed from GI tract following oral admin. Peak plasma levels:1-3 hours. With bid admin of 100 mg, steady-state is achieved within 24-36 hours.


Routes of Administration and Dosage:

Oral dosage form in adults :100 mg b.i.d In children : 5 mg/kg/day in 2 or 3 divided doses.

Nimesulide Drug uses:

• Nimesulide has less gastrointestinal adverse effects than other NSAIDs
• It has superior benefit-risk ratio to other drugs with a comparable safety and tolerability to placebo.
• Its multifactorial mode of action gives it a unique and broad action on inflammatory.
• Nimesulide is also safe in sensitive asthmatic patients. It is reported to be beneficial in relieving the symptoms of rhinitis, rhinopharyngitis tubaritis and seceretory otitis media with concomitant antibiotic treatment.
• Nimesulide has potent analgesic, anti-inflammatory and antipyretic activities

Nimesulide Efficacy

The abilities of NSAID’s drug nimesulide to inhibit COX-2 preferentially and to exert other novel anti-inflammatory actions are consistent with good efficacy and safety with highly effective in reducing pain, inflammation and also helps in better penetration of the antibiotics.

Nimesulide posses analgesic properties with multifactorial mode of action for the treatment of musculoskeletal system, dysmenorrhoea, and acute pain .

It also undergoes extensive biotransformation. The recent study on the basis of analgesic activity of nimesulide has proved that Nimesulide had a quicker onset which shows relief from pain relief and inflammation within 15 minutes from drug intake.

Nimesulide is recommended for the shortest duration necessary to control symptoms in patients with acute pain or primary dysmenorrhoea.

Nimesulide 100mg Uses

Nimesulide 100mg Therapeutic indications:

• Treatment of acute pain
• Symptomatic treatment of painful osteoarthritis
• Primary dysmenorrhoea.

Nimesulide 100mg Tablets/granules should be used for the shortest possible duration, as required by the clinical situation.

Adults:

100mg bid after meal.

Elderly:

In elderly patients there is no need to reduce the daily dosage.

Children (< 12 years):

Nimesulide 100mg Tablets/granules is contraindicated in these patients.

Adolescents (from 12 to 18 years):

on the basis of the kinetic profile in adults and on the

pharmacodynamic characteristics of nimesulide, no dosage adjustment in these patients is necessary.

 

Nimesulide 100mg Uses:

• Analgesic and antipyretic.
• Rheumatoid arthritis, osteoarthritis, other degenerative joint disorders.
• Musculo skeletal disorders.
• Thrombophlebitis.

Nimesulide Dose

The main purpose of Nimesulide tablets is for the treatment of painful inflammatory conditions, back pain, dysmenorrhea, postoperative pain, osteoarthritis, and fever.

Oral dosage form prescribed for the shortest duration

In adults:100 mg
In children: 5 mg/kg/day in 2 or 3 divided doses.

Nimesulide has superior gastrointestinal safety as compared to other NSAIDs. Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.

Nimesulide tablet prevents cancer by inhibiting the proliferation of various types of cancer cells mainly via COX-2 independent mechanisms. It is also used for dry skin, to improve skin-tone,and to increase energy.

Nimesulide treatment  also brought about an immediate and significant improvement in over-all pain, exudation, oedema and headache.

Nimesulide Solubility

Nimesulide is a preferential COX-2 inhibitor most commonly prescribed for the treatment of various inflammatory conditions such as tonsillitis, pharyngitis, stomatitis, rheumatoid arthritis, osteoarthritis, low back pain.

It has high anti-inflammatory, antipyretic. Solubility of Nimesulide was studied using different cosolvent mixtures and various classes of non-ionic surfactant.

Solubility Increased on solubilization of drug in semi-polar solvents and non-ionic surfactants. Solubility increased drastically (>70 mg/rnl) when polyethylene glycol 300 and polyethylene glycol 400 were used as solvents.

The quick dissolving tablets of Nimesulide contains superdisintegrants, that accelerates the disintegration of tablets by virtue of their ability to soak up great deal of water once exposed to binary compound surroundings.

Nimesulide Brands

NSAID’s tablet Nimesulide is a widely prescribed anti-inflammatory analgesic drug belongs to BCS class II which is required for the quick treatment of severe muscular pains and inflammatory problems.

NSAID’s tablet Nimesulide is been available since 1985 and sanction with assorted trade names in worldwide in abundance of 50 countries.

Different trademarks of Nimesulide are: Sulide, Nimalox, Nimesil, Nimulid, Nicip, Nimcap, Nise, Sulidene and Zolan.

Nimesulide tablet incorporates:

• Fast results
• Helpful and supportive
• No feature impacts
• Fast and quick effects

Nimulid and Nise which are brands from Nimesulide

Nimulid is used for post-traumatic irritation, extreme musculoskeletal issue including sprains, strains, tendinitis, tenosynovitis, low spinal pain, periarthritis (shoulder anguish) and osteoarthritis (joint torments), immovability.

Where as, Nise (100 mg) – Tablet, contains Generic Medicine Nimesulide- 100 mg. which is a non-steroidal alleviating drug.

Main Purpose of using Nimesulide drug is to:

• Treat exceptional torment from degenerative joint disease. 
• Treat crucial dysmenorrhoea in youngsters and adults in excess of 12 years old. 
• Treat various sorts of torments coming to fruition as a result of recreations harm, dejection and so forth. 
• Treat Cancer Treat dry skin

Nimesulide Tablet Synthesis

Nimesulide is a non-steroidal anti-inflammatory agent that is generally utilized as a part of the treatment of inflammatory torment which hinders the protein cyclooxygenase-2 (COX-2) and has better gastro-intestinal mediocrity in addition to different NSAIDs in its class.

Its approved signs are the treatment of intense torment, the symptomatic treatment of osteoarthritis and essential dysmenorrhoea, sports wounds and so on.

A mixed bag of new nimesulide subsidiaries were synthesized through incorporation of a 5-LOX pharmacophore into Nimesulide took after with some structural changes. which were then portrayed for double protein inhibitors for these two sorts of enzymes (Cyclooxygenase-½ (COX-½) and 5-lipoxygenase (5-LOX) )

Clinically it has demonstrated that it supports an especially good profile as far as gastrointestinal tolerability

Nimesulide 100mg Medicine

Non-steroidal anti-inflammatory drug Nimesulide, prescribed for painful inflammatory conditions, back pain, dysmenorrhea, postoperative pain, osteoarthritis, and fever.

 

Nimesulide is also indicated in painful inflammatory conditions associated with musculoskeletal system, dysmenorrhoea, Thrombophlebitis, dental pain and in ENT inflammation.

 

Usage of Nimesulide 100mg- Tablet:

• Analgesic and antipyretic.
• Rheumatoid arthritis, osteoarthritis, other degenerative joint disorders.
• Musculo skeletal disorders.
• Thrombophlebitis.

Nimesulide tablet has great analgesic and antipyretic properties which is nothing but relief from pain and reduction of body temperature.

Nimesulide should be used only with the medical prescription. A prescription can be considered appropriate when it is in accordance with the approved indications of a drug in terms of demonstrated efficacy, dosage, and treatment duration.

Nimesulide Tablet Formulation and its Advantages

Nimesulide, a widely prescribed anti-inflammatory analgesic drug belongs to BCS class II and exhibit low and variable oral bioavailability.

 

Nimesulide (4-nitro-2-phenoxymethanesulfoanilide) may be a particular Cox-2 anti-inflammatory medication. This compund, a by-result of p-nitrophenyl methane arrangement sulfa, is structurally a solitary non-steroidal anti-inflammatorydrug. It has a place with particular COX-2inhibitors, with an intense pain relieving movement.

its shown as second line treatment for  acute pain, symptomatic treatment of excruciating degenerative joint ailment and first dysmenorrhoea.

Nimesulide tablet incorporates:

• Fast results
• Helpful and supportive
• No feature impacts
• Fast and quick effects

Nimesulide Tablet Advantages:

• Nimesulide has less gastrointestinal adverse effects than other NSAIDs
• It has superior benefit-risk ratio to other drugs with a comparable safety and tolerability to placebo.
• Its multifactorial mode of action gives it a unique and broad action on inflammatory.
• Nimesulide is also safe in sensitive asthmatic patients. It is reported to be beneficial in relieving the symptoms of rhinitis, rhinopharyngitis tubaritis and seceretory otitis media with concomitant antibiotic treatment. 
• Nimesulide has potent analgesic, anti-inflammatory and antipyretic activities

Nimesulide and Paracetamol Uses

Pharmacodynamic Nimesulide – is an inhibitor of cyclooxygenase so it inhibits synthesis of destructive prostaglandins and spares cytoprotective prostaglandins. Nimesulide appears to exert its effects also through a variety of other mechanisms and involves interference with the production action of mediators other than prostaglandins such as enzymes, toxic oxygen derivatives, cytokines, platelet activating factor and histamine.

Paracetamol – is a valuable central analgesic but weak peripheral anti-inflammatory agent and exhibits agent and exhibits antipyretic action.

Pharmacokinetic Nimesulide – after oral administration the peak plasma concentrations of 1.98-9.85 mg/L are achieved within 1 to 2hrs.

Paracetamol – is rapidly and completely absorbed from gastrointestinal tract. Peak plasma is achieved within 2 to 3hrs

Nimesulide suspension (1.5 mg/kg three times daily) or paracetamol syrup (10 mg/kg four times daily) were administered orally till fever resolved. blood heat was recorded and native pain and general discomfort assessed.

According to the result, Nimesulide was as effective as paracetamol in reducing fever, local pain, and general discomfort. Nimesulide therefore appears to be a minimum of as effective as paracetamol in terms of antipyretic and anti inflammatory activity in children with inflammation of the upper tract and fever.

The other recent study with the patients aged between twelve and sixty years on the premise of analgesic effectiveness and tolerability has well-tried that the analgesic results of Nimesulide had a faster onset (<15 minutes) and was stronger (based on patient opinion). And were well tolerated.

Indications:

Sprains, wounds, injury Post surgical plan Dental pain Arthritic Pain pain, fever inflammation accompanying respiratory track infection and ENT conditions

Nimesulide Gel uses

The anti-inflammatory activity of topically applied Nimesulide gel commonly used in the management of Musculoskeletal injuries.
Nimesulide gel possesses higher anti-inflammatory activity compared to other gel’s.

The superior analgesic activity of Nimesulide transdermal gel has reported good results in terms of decreasing pain and improved functions in musculoskeletal conditions after topical application.

 

Nimesulide transdermal gel is a novel hydroalcoholic microcarrier based drug delivery system with penetration enhancer.

 

Treatment:

Nimesulide gel is demonstrated for an assortment of conditions depicted by anguish, irritation and strength, for instance, osteoarthritis, periarthritis, post-traumatic or extreme musculoskeletal issue including tendinitis, tenosynovitis, sprains, strains and low back torment. It Functions via limiting particular nerve inspirations sent from the edge to your central system.

Nimesulide Tablet Uses

Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) which acts as a cyclooxygenase- 2 inhibitor. It has become a leading NSAID in over 50 countries worldwide.

Nimesulide tablet is used for the treatment of osteoarthritis, postoperative trauma, sports injuries, acute musculoskeletal disorders including tendonitis, tenosynovitis, sprains, strains and low back pain, ear, nose and throat disorders

Usage of Nimesulide 100mg- Tablet:

• Nimesulide has less gastrointestinal adverse effects than other NSAIDs 
• It has superior benefit-risk ratio to other drugs with a comparable safety and tolerability to placebo.
• Its multifactorial mode of action gives it a unique and broad action on inflammatory. 
• Nimesulide is also safe in sensitive asthmatic patients. It is reported to be beneficial in relieving the symptoms of rhinitis, rhinopharyngitis tubaritis and seceretory otitis media with concomitant antibiotic treatment. 
• Nimesulide has potent analgesic, anti-inflammatory and antipyretic activities
• Nimesulide tablet undergoes extensive biotransformation and has a relatively rapid onset of action, with meaningful reductions in pain and inflammation observed within 15 minutes from drug intake.

Its an anti-inflammatory with analgesic and antipyretic activity. It is also has low gastro-intestinal and renal toxicity.

Nimesulide Tablet drug bank

Nimesulide is an exceptional non- steroidal anti-inflammatory drug which was launched in Italy for the first time as Aulin and Mesulid in 1985 and is presently available in more than 50 countries worldwide with different trademarks.

Nimesulide is generally endorsed for the treatment of intense torment, joint ache and essential dysmenorrhoea.

Brands:

Nimesulide is accessible in worldwide among 50 nations with different brands like Sulide, Nimalox, Nimesil, Nimulid, Nicip, Nimcap, Nise, Sulidene and Zolan.

Pharmacology:

Food, gender and advanced age have negligible effects on Nimesulide pharmacokinetics.

Evidences:

Sprains, wounds, damage Post surgical arrangement Dental torment Arthritic ache, fever aggravation going with respiratorty track disease and ENT conditions
 

Nise Tablet Benefits

“Nise” tablet is a trademark for the drug “Nimesulide" which is a multifactorial approach characterized by a fast onset of analgesic activity.

Nise tablet shows significant progress in the treatment post-traumatic inflammation, acute musculoskeletal disorders, and osteoarthritis (joint pains).

Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.

Nise 100mg Tablet Uses:

• Nimesulide has less gastrointestinal adverse effects than other NSAIDs
• It has superior benefit-risk ratio to other drugs with a comparable safety and tolerability to placebo.
• Its multifactorial mode of action gives it a unique and broad action on inflammatory.
• Nimesulide is also safe in sensitive asthmatic patients. It is reported to be beneficial in relieving the symptoms of rhinitis, rhinopharyngitis tubaritis and seceretory otitis media with concomitant antibiotic treatment.
• Nimesulide has potent analgesic, anti-inflammatory and antipyretic activities

It is available in the form of capsule, tablet and gel with the dosage of 100mg. Nice tablet shows instant pain relief from acute pain.

Nimesulide Medicine

The European Medicines Agency has completed a review of the safety and effectiveness of medicines containing Nimesulide (capsules, tablets, suppositories and powder or granules for oral suspension).

It has concluded that Nimesulide has great benefits for the treatment of acute pain and primary dysmenorrhoea. It issued a recommendation that it should be used for the shortest duration (<15days).

It is also used for dry skin and to improve skin tone. Usage of Nimesulide 100mg- Tablet.

• Nimesulide has less gastrointestinal adverse effects than other NSAIDs
• It has superior benefit-risk ratio to other drugs with a comparable safety and tolerability to placebo.
• Its multifactorial mode of action gives it a unique and broad action on inflammatory.
• Nimesulide is also safe in sensitive asthmatic patients. It is reported to be beneficial in relieving the symptoms of rhinitis, rhinopharyngitis tubaritis and seceretory otitis media with concomitant antibiotic treatment.
• Nimesulide has potent analgesic, anti-inflammatory and antipyretic activities

Nimesulide tablet has great analgesic and antipyretic properties which is nothing but relief from pain and reduction of body temperature. Nimesulide medicines are recommended for short duration of 15days

Nimesulide Drug Advantages

Nimesulide is a non-steroidal anti inflammatory drug prescribed for the treatment of acute pain, joint pain and primary dysmenorrhoea.

Advantages for the treatment of Nimesulide:

• Nimesulide has less gastrointestinal adverse effects than other NSAIDs.
• It has superior benefit-risk ratio to other drugs with a comparable safety and tolerability to placebo. 
• Its multifactorial mode of action gives it a unique and broad action on inflammatory. 
• Nimesulide is also safe in sensitive asthmatic patients. 
• It is reported to be beneficial in relieving the symptoms of rhinitis, rhinopharyngitis tubaritis and seceretory otitis media with concomitant antibiotic treatment.
• Nimesulide has potent analgesic, anti-inflammatory and antipyretic activities.

Dose: 

Nimesulide is available with the dosage of 100mg its measurements ought to be taken by medicine of doctor and specialist which will help to take proper dosage for good come about. Nimesulide is recommended to be used for the shortest duration

Comparision of Nimesulide and Paracetamol Tablets

Pharmacodynamic Nimesulide – is an inhibitor of cyclooxygenase so it inhibits synthesis of destructive prostaglandins and spares cytoprotective prostaglandins. Nimesulide appears to exert its effects also through a variety of other mechanisms and involves interference with the production action of mediators other than prostaglandins such as enzymes, toxic oxygen derivatives, cytokines, platelet activating factor and histamine.

Paracetamol – is a valuable central analgesic but weak peripheral anti-inflammatory agent and exhibits agent and exhibits antipyretic action.

Pharmacokinetic Nimesulide – after oral administration the peak plasma concentrations of 1.98-9.85 mg/L are achieved within 1 to 2hrs.

Paracetamol – is rapidly and completely absorbed from gastrointestinal tract. Peak plasma is achieved within 2 to 3hrs

Nimesulide suspension (1.5 mg/kg three times daily) or paracetamol syrup (10 mg/kg four times daily) were administered orally till fever resolved. blood heat was recorded and native pain and general discomfort assessed.

According to the result, Nimesulide was as effective as paracetamol in reducing fever, local pain, and general discomfort. Nimesulide therefore appears to be a minimum of as effective as paracetamol in terms of antipyretic and anti inflammatory activity in children with inflammation of the upper tract and fever.
The other recent study with the patients aged between twelve and sixty years on the premise of analgesic effectiveness and tolerability has well-tried that the analgesic results of Nimesulide had a faster onset (<15 minutes) and was stronger (based on patient opinion). And were well tolerated.

Indications: Sprains, wounds, injury Post surgical plan Dental pain Arthritic Pain pain, fever inflammation accompanying respiratorty track infection and ENT conditions

Uses of Nimesulide Gel

Nimesulide is a unique non- steroidal anti-inflammatory drug that acts specifically on cyclo-oxygenase-2 which exerts less gastrointestinal adverse effects than other NSAIDs, and is mostly prescribed for the treatment of acute pain, joint pain and primary dysmenorrhoea.

Nimesulide is available in variety of forms like in the form of tablets and syrup for oral administration and gels for topical application.

Nimesulide transdermal gel is a well endured novel hydroalcoholic microcarrier based drug delivery system with penetration enhancer.

Indications:
Nimesulide gel is indicated for a variety of conditions portrayed by agony, aggravation and solidness, for example, osteoarthritis, periarthritis, post-traumatic or intense musculoskeletal issue including tendinitis, tenosynovitis, sprains, strains and low back torment. It Functions by restraining specific nerve motivations sent from the outskirts to your focal framework.

Nimesulide Tablet Formulation

Nimesulide, a widely prescribed anti-inflammatory analgesic drug belongs to BCS class II and exhibit low and variable oral bioavailability.

 

Nimesulide (4-nitro-2-phenoxymethanesulfoanilide) may be a particular Cox-2 anti-inflammatory medication. This compund, a by-result of p-nitrophenyl methane arrangement sulfa, is structurally a solitary non-steroidal anti-inflammatorydrug. It has a place with particular COX-2inhibitors, with an intense pain relieving movement.

its shown as second line treatment for  acute pain, symptomatic treatment of excruciating degenerative joint ailment and first dysmenorrhoea.

Nimesulide tablet incorporates:

• Fast results
• Helpful and supportive
• No feature impacts
• Fast and quick effects

Nimesulide Tablet Advantages:

• Nimesulide has less gastrointestinal adverse effects than other NSAIDs
• It has superior benefit-risk ratio to other drugs with a comparable safety and tolerability to placebo.
• Its multifactorial mode of action gives it a unique and broad action on inflammatory.
• Nimesulide is also safe in sensitive asthmatic patients. It is reported to be beneficial in relieving the symptoms of rhinitis, rhinopharyngitis tubaritis and seceretory otitis media with concomitant antibiotic treatment. 
• Nimesulide has potent analgesic, anti-inflammatory and antipyretic activities

Nimesulide Painkiller tablet

A unique Non-steroidal anti inflammatory drug Nimesulide was developed by Helsinn Healthcare and is marketed world-wide around 50 countries. It has proven benefits in the treatment of Acute (short term) pain, Painful osteoarthritis (Swelling in the joints) and Primary dysmennorhea ( Period Pains).

Nimesulide is a prescription anti-inflammatory drug with significant analgesic properties and antipyretic properties. It has superior gastrointestinal safety as compared to other NSAIDs.

Indications:

• Pain relief
• Rheumatoid arthritis
• Osteoarthritis
• Low back pain
• Post operative pain management
• Gynecological surgery: Hysterectomy,
• Dental pain

Nimesulide drug must be prescribed by a physician and doctor and is usually recommended for the age higher than 12 years.

Nimesulide is available with distinctive brands like Sulide, Nimalox, Nimesil, Nimulid, Nicip, Nimcap, Nise, Sulidene and Zolan.

Solubiltiy of Nimesulide in various solvents

Nimesulide is a unique non- steroidal anti-inflammatory drug which is most commonly prescribed for the treatment of various inflammatory conditions such as tonsillitis, pharyngitis, stomatitis, rheumatoid arthritis, osteoarthritis, low back pain.

A variety of Nimesulide forms are available in the market like in the form of tablets and syrup for oral administration and gels for topical application.

Solubility of Nimesulide in various solvents and solvent-co-solvent mixtures was determined in relation to the development of parenteral formulations.

Nimesulide is soluble in organic solvents like alcohol, DMSO, and dimethyl formamide (DMF).

The quick dissolving tablets of Nimesulide contains superdisintegrants, that accelerates the disintegration of tablets by virtue of their ability to soak up great deal of water once exposed to binary compound surroundings.

Nimesulide Tablet Advantages

Nimesulide is a non-steroidal anti inflammatory drug prescribed for the treatment of acute pain, joint pain and primary dysmenorrhoea.

Advantages for the treatment of Nimesulide:

• Nimesulide has less gastrointestinal adverse effects than other NSAIDs
• It has superior benefit-risk ratio to other drugs with a comparable safety and tolerability to placebo.
• Its multifactorial mode of action gives it a unique and broad action on inflammatory.
• Nimesulide is also safe in sensitive asthmatic patients. It is reported to be beneficial in relieving the symptoms of rhinitis, rhinopharyngitis tubaritis and seceretory otitis media with concomitant antibiotic treatment. 
• Nimesulide has potent analgesic, anti-inflammatory and antipyretic activities

Dose:

• Nimesulide is available with the dosage of 100mg its measurements ought to be taken by medicine of doctor and specialist which will help to take proper dosage for good come about.
• Nimesulide is recommended to be used for the shortest duration

Nimesulide Tablet Brands

NSAID’s tablet Nimesulide is been available since 1985 and sanction with assorted trade names in worldwide in abundance of 50 countries.

Main purpose of using Nimesulide drug is to:

• Treat exceptional torment from degenerative joint disease.
• Treat crucial dysmenorrhoea in youngsters and  adults in excess of 12 years old.
• Treat various sorts of torments coming to fruition as a result of recreations harm, dejection and so forth.
• Treat Cancer
• Treat dry skin

Nimesulide is available in distinctive brands, for instance, Sulide, Nimalox, Nimesil, Nimulid, Nicip, Nimcap, Nise, Sulidene and Zolan.

Nimulid is used for post-traumatic irritation, extreme musculoskeletal issue including sprains, strains, tendinitis, tenosynovitis, low spinal pain, periarthritis (shoulder anguish) and osteoarthritis (joint torments), immovability.

Nise (100 mg) – Tablet, contains Generic Medicine Nimesulide- 100 mg. which is a non-steroidal alleviating drug

Nimesulide Gel for pain relief

Nimesulide transdermal gel is a well endured novel hydroalcoholic microcarrier based drug delivery system with penetration enhancer. This is reason for predominant adequacy of Nimesulide Transdermal Gel and it is connected principally for topical agony administration.

Nimesulide is a non-steroidal mitigating( (NSAID) operators which have pain relieving properties. The product has been formed utilizing a novel mix of solvents for solubilization of Nimesulide.

Nimesulide gel is indicated for a variety of conditions portrayed by agony, aggravation and solidness, for example, osteoarthritis, periarthritis, post-traumatic or intense musculoskeletal issue including tendinitis, tenosynovitis, sprains, strains and low back torment. It Functions by restraining specific nerve motivations sent from the outskirts to your focal framework.

Nimesulide displayed better efficacy it likewise exhibited speedier onset of activity. Significant concentration of Nimesulide could be detected in the blood within 30 minutes of treatment and persisted for 8 hours post treatment

Nimesulide Tablet Solubility

Nimesulide NSAID’s tablet is an efficient and safe therapeutic selection for the treatment of assorted painful inflammatory conditions like inflammation, sore throat, stomatitis, arthritis, degenerative joint disease, low back pain etc., with a speedy onset of analgesic activity.

The quick dissolving tablets of Nimesulide contains superdisintegrants, that accelerates the disintegration of tablets by virtue of their ability to soak up great deal of water once exposed to binary compound surroundings.

Nimesulide is soluble in organic solvents like alcohol, DMSO, and dimethyl formamide (DMF).

Nimesulide is out there in varied forms like Nimesulide Tablets, Nimesulide Powder/granules, Nimesulide Gel, suppositories.

Clinical proved that it is available to support a particularly good profile in terms of gastrointestinal tolerability.

The employment of Nimesulide is usually recommended for the shortest length necessary to regulate symptoms in patients with acute pain or primary dysmenorrhoea.

Nimesulide Tablet for cancer treatment

Cancer, also known as a malignant tumour or malignant neoplasm, which is caused due to a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. Cyclooxygenase-2 (COX-2) inhibitor.

Nimesulide inhibits the proliferation of various types of cancer cells mainly via COX-2 independent mechanisms, which makes it a good lead compound for anti-cancer drug development.

There are more than 100 types of cancer, including breast cancer, skin cancer, lung cancer, colon cancer, prostate cancer, and lymphoma. Symptoms vary depending on the type.

A series of new Nimesulide analogs were synthesized based on the structure–function analysis generated previously. It displayed very potent anti-cancer activity.

Significantly suppresses the growth of multiple cancer. By usng Nimesulide the sizes of the colon carcinomas were also decreased.

Pharmacokinetic studies demonstrate the good bioavailability of the compound. A set of non-COX-2 active Nimesulide anti-cancer derivatives were synthesized. It works as a good lead compound for anti-cancer drug development

Drug bank of Nimesulide medicine

Non-steroidal drug Nimesulide endorsed evidences are the treatment of intense agony, the symptomatic treatment of osteoarthritis and essential dysmenorrhoea, sports wounds and so on.

It has special properties of pain relieving and antipyretic which, specially inhibits the chemical cyclooxygenase-2 (COX-2) and has better gastro-intestinal tolerability.

It is utilized for treatment of different sorts of agonies coming about because of games harm, despondency and so on.

Dose:
Nimesulide is available with the dosage of 100mg its measurements ought to be taken by medicine of doctor and specialist which will help to take proper dosage for good come about.

Pharmacology:
Sustenance, sexual orientation and progressed age have insignificant impacts on nimesulide pharmacokinetics.

Uses:

• Analgesic and antipyretic.
• Rheumatoid arthritis, osteoarthritis, other degenerative joint disorders.
• Musculo skeletal disorders.
• Thrombophlebitis.

Nimesulide tablet dose

The main purpose of Nimesulide tablets is for the treatment of painful inflammatory conditions, back pain, dysmenorrhea, postoperative pain, osteoarthritis, and fever.

Oral dosage form in adults :100 mg and In children : 5 mg/kg/day in 2 or 3 divided doses. It is prescribed for the shortest duration.

Nimesulide has superior gastrointestinal safety as compared to other NSAIDs. Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.

Nimesulide tablet prevents cancer by inhibiting the proliferation of various types of cancer cells mainly via COX-2 independent mechanisms. It is also used for dry skin, to improve skin-tone,and to increase energy.

Nimesulide treatment  also brought about an immediate and significant improvement in over-all pain, exudation, oedema and headache.

Nimesulide Formulation and features

Nimesulide, a wide endorsed medicine pain relieving drug fits in with BCS classification II and show low and variable oral bioavailability.

Nimesulide (4-nitro-2-phenoxymethanesulfoanilide) may be a particular Cox-2 anti-inflammatory medication. This compund, a by-result of p-nitrophenyl methane arrangement sulfa, is structurally a solitary non-steroidal anti-inflammatorydrug. It has a place with particular COX-2inhibitors, with an intense pain relieving movement.

its shown as second line treatment for  acute pain, symptomatic treatment of excruciating degenerative joint ailment and first dysmenorrhoea.

It's conjointly utilized for the treatment of skin-tone, Heart illnesses and dry skin.

Nimesulide tablet features incorporate :

• Fast results
• Helpful and supportive
• No feature impacts
• Fast and quick effects

Use of Nimesulide 100mg- pill :

• Pain relieving and antipyretic.
• Rheumatic inflammatory sickness, degenerative joint ailment, elective perpetual joint issue treatment
• Musculo skeletal issue treatment
• Thrombophlebitis.
• Enhances skintone
• Heart Diseases
• Dry Skin
• Malignancy treatment

Nimesulide Medicine for Joint pain treatment

Joint ache influenced by osteoarthritis (OA) which is a gathering of mechanical abnormailities including debasement of joints, and NSAID’s – Nimesulide is most regularly used to treat agony connected with OA.

The primary symptom is agony, creating loss of capacity and regularly solidness. Osteoarthritis (OA) is brought about by aging joints, damage, and obesity. OA usually influences the hands, feet, spine, and the expansive weight bearing joints, for example, the hips and knees.


Nimesulide proved to be significantly more viable in giving symptomatic relief. Nimesulide speaks to a successful operator for the treatment of joint ache, with specific reference to the quick onset of its pain relieving impact.

It additionally utilized for the treatment of primary Dysmenorrhea, and Acute ache.

Nimesulide shows significant diminishments in pain and irritation observed in 15 minutes with pain relieving and antipyretic properties.

Nimesulide Drug Composition

Nimesulide, a wide proposed drug pain relieving medication has a place with sulfonanilide class II and show low and variable oral bioavailability. Nimesulide tablets is generally utilized in inflammatory pain.

Nimesulide (4-nitro-2-phenoxymethanesulfoanilide) is a particular Cox-2 calming medication. This intensify, a by-result of p-nitrophenyl methane arrangement sulfa, is structurally a particular non-steroidal mitigating medication.

It groups antihistaminic, pain relieving and antipyretic properties.

Nimesulide tablet experiences extensive biotransformation and has a generally fast onset of activity, with significant diminishments in agony and irritation saw inside 15 minutes from medication consumption.

Nimesulide is likewise being broadly utilized for anticancer and antiviral operators, and dental surgery.

Nimesulide Synthesis

Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties which, preferentially inhibits the enzyme cyclooxygenase-2 (COX-2)

It has better gastro-intestinal tolerability among other NSAIDs in its class. Its approved indications are the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea, sports injuries etc.

A variety of new nimesulide derivatives were synthesized through incorporation of a 5-LOX pharmacophore into Nimesulide followed with some structural modifications. which were then characterized for dual enzyme inhibitors for these two types of enzymes (Cyclooxygenase-½ (COX-½) and 5-lipoxygenase (5-LOX) )

Clinically it has proven that it supports a particularly good profile in terms of gastrointestinal tolerability.

Nimesulide Gel

Nimesulide tablets is available in gel formulation and applied mainly for topical pain management.

Nimesulide transdermal gel is a well tolerated novel hydroalcoholic microcarrier based drug delivery system with penetration enhancer. This is cause of superior efficacy of Nimesulide Transdermal Gel.

 

Nimesulide gel is indicated for a variety of conditions characterized by pain, inflammation and stiffness, such as osteoarthritis, periarthritis, post-traumatic or acute musculoskeletal disorders including tendinitis, tenosynovitis, sprains, strains and low back pain. It Functions by inhibiting particular nerve impulses sent from the periphery to your central system.

 

Nimesulide is a non-steroidal anti-inflammatory (NSAID) agent which also possess analgesic properties. The product has been formulated using a novel combination of solvents for solubilization of Nimesulide.

 

Nimesulide exhibited better efficacy it also demonstrated faster onset of action. Significant concentration of Nimesulide could be detected in the blood within 30 minutes of treatment and persisted for 8 hours post treatment

Nimesulide Tablets and it's various Forms

The best prescribed Nimesulide tablet is used for the treatment of acute pain, Primary dysmennorhea and also to treat degenerative joint disease.

Apart from tablet the drug- Nimesulide is also available in various forms such as in the form of Gell, powder, and suppositories with the dosage of 100 mg for tablets, 100 mg for granules for oral suspension, 200mg for suppositories and 3% of gel.

Nimesulide is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF).

Nimesulide transdermal gel is a well tolerated novel hydroalcoholic microcarrier based drug delivery system with penetration enhancer.

 

Nimesulide gel is indicated for a variety of conditions characterized by pain, inflammation and stiffness, such as osteoarthritis, periarthritis, post-traumatic or acute musculoskeletal disorders including tendinitis, tenosynovitis, sprains, strains and low back pain.
It’s also available in various brand names of Sulide, Nimalox, Nimesil, Nimulid, Nicip, Nimcap, Nise, Sulidene and Zolan e.t.c. which is available in more than 50 countries world wide.

Comparision of Nimesulide and Paracetamol Tablets

The effectivity and tolerability of nimesulide were compared with those of paracetamol in an exceedingly non blind randomized study that recruited 110 kids (64 males, 46 females; aged 3 to 6 years) with inflammation of the higher tract and fever.

Nimesulide suspension (1.5 mg/kg three times daily) or paracetamol sirup (10 mg/kg four times daily) were administered orally till fever resolved. blood heat was recorded and native pain and general discomfort assessed.

Nimesulide was as effective as paracetamol in reducing fever, local pain, and general discomfort. Nimesulide therefore appears to be a minimum of as effective as paracetamol in terms of antipyretic and anti inflammatory activity in children with inflammation of the upper tract and fever.

The other recent study with the patients aged between twelve and sixty years on the premise of analgesic effectiveness and tolerability has well-tried that the analgesic results of Nimesulide had a faster onset (<15 minutes) and was stronger (based on patient opinion). And were well tolerated.

Nimesulide is suggested for the shortest length necessary to regulate symptoms in patients with acute pain or primary dysmenorrhoea.

Nimesulide Tablet Indications

Anti-inflammatory Analgesics tablet – Nimesulide is very much required for the quick treatment of severe muscular pains and inflammatory problems. NImesulide tablets is available in different countries in the world.

Information:

Nimesulide is indicated in painful inflammatory conditions associated with musculoskeletal system, dysmenorrhoea, Thrombophlebitis, dental pain and in ENT inflammation.

Features:

• Desirable results
• Helpful and beneficial
• No side effects
• Fast and quick effects

Nimesulide 100mg Tablets/granules should be used for the shortest possible duration, as required by

the clinical situation.

 

Indications:

 

Tablets or Granules: 100 mg twice a day after meals

400 mg nimesulide-beta-cyclodextrin Tablets or Granules: 400 mg (= 100 mg nimesulide)

twice a day after meals

Suppositories: 200 mg twice a day

Nimesulide Drug Composition

Nimesulide, a wide recommended medication analgesic drug belongs to sulfonanilide class II and exhibit low and variable oral bioavailability.

Nimesulide (4-nitro-2-phenoxymethanesulfoanilide) is a selective Cox-2 anti-inflammatory drug. This compound, a by-product of p-nitrophenyl methane series sulfa, is structurally a singular non-steroidal anti-inflammatory drug.

It posses antihistaminic, analgesic and antipyretic properties.

NImesulide medication is used in the treatment for acute pain, symptomatic treatment of painful degenerative joint disease and first dysmenorrhoea.

It’s conjointly used for the treatment of skin-tone, Heart diseases, Cancer and dry skin. It likewise gives Quick and quick impacts with its rapid pain relief. It is also used for increasing energy

Nimesulide Tablet for the treatment of Cancer

Cancer, otherwise called a dangerous tumor or harmful neoplasm, is a gathering of ailments including irregular cell development with the possibility to attack or spread to different parts of the body. Cyclooxygenase-2 (COX-2) inhibitor Nimesulide represses the expansion of different sorts of malignancy cells mainly through COX-2 independent mechanisms, which makes it a good lead compound for hostile to disease drug improvement.

There are more than 100 sorts of cancer, including breast tumor, skin malignancy, lung disease, colon malignancy, prostate malignancy, and lymphoma. Manifestations fluctuate relying upon the sort.

An arrangement of new Nimesulide analogs were synthesized focused around the structure–function examination produced previously. It showed exceptionally strong hostile to malignancy movement.

Fundamentally supress the development of numerous growth. By using Nimesulide the sizes of the colon carcinomas were additionally diminished.

Pharmacokinetic studies exhibit the great bioavailability of the compound. A set of non-COX-2 dynamic Nimesulide anti-cancer derivatives were synthesized. It acts as a decent lead compound for against tumor drug advanceme

Osteoarthritis pain tablet - Nimesulide

Joint pain affected by osteoarthritis (OA) which is a group of mechanical abnormalities involving degradation of joints, and NSAIDs - Nimesulide is most commonly used to treat pain associated with OA.

The main symptom is pain, causing loss of ability and often stiffness. Osteoarthritis (OA) is caused by aging joints, injury, and obesity. OA commonly affects the hands, feet, spine, and the large weight bearing joints, such as the hips and knees,

cyclo-oxygenase (COX)-2-selective inhibitors have been proved to have certain advantages over non-selective NSAIDs and have been increasingly used for pain management in patients with OA.

Nimesulide proved to be significantly more effective in providing symptomatic relief. Nimesulide represents an effective agent for the treatment of joint pain, with particular reference to the rapid onset of its analgesic effect.

It also used for the treatment of primary Dysmenorrhea, and Acute pain.

Nimesulide shows meaningful reductions in pain and inflammation observed within 15 minutes with its analgesic and antipyretic properties.

Nimesulide tablet formula and ts prupose

Nimesulide, a wide prescribed medication analgesic drug belongs to BCS category II and exhibit low and variable oral bioavailability.

Nimesulide (4-nitro-2-phenoxymethanesulfoanilide) may be a selective Cox-2 anti-inflammatory drug drug. This compound, a by-product of p-nitrophenyl methane series sulfa, is structurally a singular non-steroidal anti-inflammatory drug.

It belongs to selective COX-2inhibitors, with a potent analgesic activity.
it’s indicated as second line treatment for acute pain, symptomatic treatment of painful degenerative joint disease and first dysmenorrhoea.

It’s conjointly used for the treatment of skin-tone, Heart diseases and dry skin. It also gives Quick and fast effects with its rapid pain relief.

It reduces heart diseases, and cancer, and also improves skin tone.

Nimesulide Medicines for pain relief

The European Medicines Agency has completed a review of the safety and effectiveness of medicines containing nimesulide (capsules, tablets, suppositories and powder or granules for oral suspension).

It has concluded that NImesulide has great benefits for the treatment of acute pain and primary dysmenorrhoea. It issued a recommendation that it shouldbe used for the shortest duration (<15days)

It is also used for dry skin and skin tome

Usage of Nimesulide 100mg- Tablet

• Analgesic and antipyretic.
• Rheumatoid arthritis, osteoarthritis, other degenerative joint disorders.
• Musculo skeletal disorders.
• Thrombophlebitis.

 Nimesulide tablet has great analgesic and antipyretic properties which is nothing but relief from pain and reduction of body temperature.

Nimesulide Tablet Synthesis

Nimesulide is a COX-2 selective drug which has the properties of antiinflammatory and antihistaminic, it also possesses analgesic properties.

Apart for the treatment of acute pain, osteoarthritis and primary dysmenorrhoea. Nimesulide is also being widely used for anticancer and antiviral agents.

A variety of new nimesulide derivatives were synthesized through incorporation of a 5-LOX pharmacophore into Nimesulide followed with some structural modifications.

Nimesulide is preffered for the shortest duration necessary to control symptoms in patients with acute pain or primary dysmenorrhoea. The efficacy of Nimesulide was consistently superior to placebo with its particularly rapid onset action.

Nimesulide is ought there in various forms like powder/granules, gel, and suppositories.

Clinically it has proven that it supports a particularly good profile in terms of gastrointestinal tolerability.

Nimesulide tablet brands

NSAIDs tablet Nimesulide is been available since 1985 and authorised with different trade names in worldwide over 50 countries.

Main purpose of using Nimesulide drug is to:

• Treat acute pain
• Treat degenerative joint disease
• Treat primary dysmenorrhoea in adolescents and adults above 12 years old
• treat all types of pains resulting from sports injury, depression etc.

Nimesulide is available in various brands such as Sulide, Nimalox, Nimesil, Nimulid, Nicip, Nimcap, Nise, Sulidene and Zolan.

Nimulid is indicated for post-traumatic inflammation, acute musculoskeletal disorders including sprains, strains, tendinitis, tenosynovitis, low back pain, periarthritis (shoulder pain) and osteoarthritis (joint pains), stiffness.

Nise (100 mg) – Tablet, contains Generic Medicine Nimesulide- 100 mg. which is a non-steroidal anti-inflammatory drug (NSAID) with Analgesic and antipyretic properties

Nimesulide Tablet Efficacy and Safety

The abilities of NSAID’s drug nimesulide to inhibit COX-2 preferentially and to exert other novel anti-inflammatory actions are consistent with good efficacy and safety and is consistently superior to placebo.

Nimesulide has proven that it gives rapid pain relief with its analgesic activity which shows relief from pain relief and inflammation within 15 minutes from drug intake.

Nimesulide must be prescribed by a licensed physician as second line treatment in the approved indications and in compliance with the recommendations

Daily dose is 100mg twice-a-day.

 As for other NSAIDs the use of nimesulide is recommended for the shortest duration necessary to control symptoms in patients with acute pain or primary dysmenorrhoea.

Nimesulide Tablet Uses

Nimesulide is a nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, anti-pyretic, and analgesic properties. It inhibits prostaglandin synthetase/cyclooxygenase, which limits prostaglandin production.

Nimesulide is required for rapid pain relief from severe muscular pains and inflammatory problems. Which gives relief from pain in 15 min.

Nimesulide is indicated in painful inflammatory conditions associated with musculoskeletal system, dysmenorrhoea, Thrombophlebitis, dental pain and in ENT inflammation.

The various inflammatory conditions such as tonsillitis, pharyngitis, stomatitis, rheumatoid arthritis, osteoarthritis, low back pain etc., can be treated by Nimesulide tablet.

Apart from that, It's also prescribed for the treatment of Skin tone, Heart disease and dry skin.

Nimesulide tablet is available in the form of granules, Gel, and Suppositories.

Nimesulide 100mg Tablets/granules should be used for the shortest possible duration, as required by
the clinical situation.

This medicine is suggested to use beneath authorized physician supervision.

Nimesulide Drug Information

Nimesulide medication developed by Helsinn Healthcare is a non-steroidal anti-inflammatory drug, indicated for painful inflammatory conditions, back pain, dysmenorrhea, postoperative pain, osteoarthritis, and fever.

Nimesulide tablets are authorised in a number of Member States. They are only available with a prescription.

It also used for the treatment of

• Skin Tone
• Heart Disease
• Dry Skin

It posses anti-inflammatory and analgesic properties. it’s an ethical medicine suggested to use medicine beneath authorised physician supervision.

Nimesulide is also available in the form of dissolving tablets, granules for oral suspension, and Gel. The fast dissolving tablets of Nimesulide contains superdisintegrants, which accelerates the disintegration of tablets by virtue of their ability to absorb large amount of water when exposed to aqueous environment.

The Nimesulide Tablets are highly effective in reducing pain, inflammation and also helps in better penetration of the antibiotics.

Nise tablet 100mg for pain treatment

Nise (100 mg) – Tablet, contains Generic Medicine Nimesulide- 100 mg. “Nise” tablet is a trademark for the drug “Nimesulide” which is a non-steroidal anti-inflammatory drug (NSAID).

Nise tablet has great analgesic and antipyretic properties which is nothing but relief from pain and reduction of body temperature.

Nise tablets is used in the treatment of acute pain, symptomatic relief of osteoarthritis(degradation of joints) and primary dysmenorrhoea (severe pain during menstruation) in females over the age of 12.

Usage of Nise (100 mg)- Nimesulide- Tablet

• Analgesic and antipyretic.
• Rheumatoid arthritis, osteoarthritis, other degenerative joint disorders.
• Musculo skeletal disorders.
• Thrombophlebitis.

It is also available in the form of Gel. Nise Gel (Nimesulide/Methyl Salicylate/Menthol/Capsaicin) is used topically. It is prescribed to apply to the affected area, rubbing in a thin layer of the gel 2 to 4 times every day.

Nimesulide Tablet in pain

Nimesuilde is a pain killer NSAIDs drug is the best prescribed drug for treatment of acute pain, Primary dysmennorhea and also to treat degenerative joint disease.

Nimesulide drug has multifactorial mode of action which, gives a unique and broad action on inflammatory processes. It also has superior gastrointestinal safety as compared to other NSAIDs. It is an analgesic and antipyretic in action, other than its anti inflammatory action.

Unlike, other NSAIDs, the chemical structure of nimesulide does not contain a carboxylic group but a sulfonanilide moiety as the acidic group.

Apart from tablet the drug- Nimesulide is also available in various forms such as in the form of Gell, powder, and suppositories. It’s also available in various brand names of Sulide, Nimalox, Nimesil, Nimulid, Nicip, Nimcap, Nise, Sulidene and Zolan e.t.c.

The Nimulid Transgel a brand from Nimesulide Transdermal Gel is indicated for post-traumatic inflammation, acute musculoskeletal disorders including sprains, strains, tendinitis, tenosynovitis, low back pain, periarthritis (shoulder pain) and osteoarthritis (joint pains), stiffness.

As with all drugs, therapy appropriateness when using nimesulide is of outmost importance to safeguard patient’s health and guarantee the product’s therapeutic value.

NImesulide is available in the dosage of 100 mgs for tablets, 100 mg for granules for oral suspension, 200mg for suppositories and 3% of gel. And the prescribed duration to use is for 15 days. 

Nimesulide Tablets Purpose

The main purpose of using Nimesulide 

• To treat acute pain 
• To treat osteoarthritis 
• To treat primary dysmenorrhoea in adolescents and adults above 12 years old.
• Increasing Energy
• Improving Skin Tone
• Heart Disease
• Dry Skin
• And are non-FDA reviewed or approved, natural alternatives, to use for , Heart Disease, and Dry Skin.

Nimesulide is a non-selective non-steroidal anti-inflammatory drug (NSAID) used for the treatment of Acute pain which, is a short-term pain, painful osteoarthritis (swelling in the joints), primary dysmenorrhoea (period pains). 

Medicines containing nimesulide have been available since 1985 and are authorised in a number of Member States. They are only available with a prescription.

  
Nimesulide drug is also known as nice tablet. It has superior gastrointestinal safety

Nimesulide Drugbank

The most prescribed Non-steroidal Anti-inflammatory pain killer drug- Nimesulide was launched in Italy by Helsinn Healthcare and is presently available in more than 50 countries worldwide with different trademarks.

Nimesulide tablet is used for treating acute pain and primary dysmenorrhoea and for the treatment of Joint Pains. he use of Nimesulide is preffered for the shortest duration necessary to control symptoms in patients

The maximum duration and dosage required to use is 15 days and 100 mg twice a day. It is available in different forms like tablet, capsule and gel, suppositories etc.

Nimesulide is a COX-2 selective tablet which posses anti-inflammatory and analgesic properties. it’s an ethical medicine suggested to use medicine beneath authorised physician supervision.

Nimesulide is available with different brands such as Sulide, Nimalox, Nimesil, Nimulid, Nicip, Nimcap, Nise, Sulidene and Zolan e.t.c

Solubility of Nimesulide in Organic Solvents

NSAID drug Nimesulide has proven benefits in the treatment of Acute (short term) pain, Painful osteoarthritis (Swelling in the joints) and Primary dysmennorhea (Period Pains).

Nimesulide is available in various forms like Nimesulide Tablets, Nimesulide Powder, Nimesulide Gel, suppositories etc.

Nimesulide is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF).

Nimesulide is an effective and safe therapeutic choice for the treatment of various painful inflammatory conditions, with a rapid onset of analgesic activity.

The prescription of a drug is appropriate when the benefit it is able to provide to a specific patient outweigh the risks associated with its use. A careful evaluation of individual risk factors is therefore of crucial importance.

As for other NSAIDs the use of Nimesulide is recommended for the shortest duration necessary to control symptoms in patients with acute pain or primary dysmenorrhoea.

Forms of Nimesulide Tablet

Nimesuilde is a pain killer NSAIDs drug is the best prescribed drug for treatment of acute pain, Primary dysmennorhea and also to treat degenerative joint disease.

Nimesulide drug was launched in Italy for the first time as Aulin and Mesulid in 1985 and is presently available in more than 50 countries worldwide with different trademarks.

Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.

It has superior gastrointestinal safety as compared to other NSAIDs. It is an analgesic and antipyretic in action, other than its anti inflammatory action.

Unlike, other NSAIDs, the chemical structure of Nimesulide does not contain a carboxylic group but a sulfonanilide moiety as the acidic group.

Apart from tablet the drug- Nimesulide is also available in various forms such as in the form of Gell, powder, and suppositories. It’s also available in various brand names of Sulide, Nimalox, Nimesil, Nimulid, Nicip, Nimcap, Nise, Sulidene and Zolan e.t.c.

The Nimulid Transgel a brand from Nimesulide Transdermal Gel is indicated for post-traumatic inflammation, acute musculoskeletal disorders including sprains, strains, tendinitis, tenosynovitis, low back pain, periarthritis (shoulder pain) and osteoarthritis (joint pains), stiffness.

As with all drugs, therapy appropriateness when using Nimesulide is of out most importance to safeguard patient’s health and guarantee the product’s therapeutic value.

Nimesulide is available in the dosage of 100 mg for tablets, 100 mg for granules for oral suspension, 200mg for suppositories and 3% of gel. And the prescribed duration to use is for 15 days. 

Nimesulide 100mg dosage

An NSAID agent- Nimesulide is widely used in the treatment of variety of painful inflammatory conditions including those associated with osteoarthritis, postoperative trauma, sports injuries, acute musculoskeletal disorders.

The most prescribed Nimesulide drug- was launched in Italy for the first time as Aulin and Mesulid in 1985 and is presently available in more than 50 countries worldwide with different trademarks.

The maximum duration and dose of a treatment course with Nimesulide medicine is 15 days, 100 mg twice a day, to minimize the risk of hepatotoxicity. It also preffered to use for the age above 12.

ts anti-inflammatory, analgesic and antipyretic activities have been demonstrated in several widely used animal experimental models.

Comparison of Suspension Composition of Nimesulide

Nimesulide is a non-steroidal anti-inflammatory agent that is widely used in the treatment of inflammatory pain.The efficacy and tolerability of nimesulide was consistently superior to placebo.

Nimesulide tablet undergoes extensive biotransformation and has a relatively rapid onset of action, with meaningful reductions in pain and inflammation observed within 15 minutes from drug intake.

The drug belongs to the class II of Biopharmaceutical Classification System (low solubility, high permeability) and therefore, absorption of this drug is limited by its dissolution.

Unlike, other NSAIDs, the chemical structure of nimesulide does not contain a carboxylic group but a sulfonanilide moiety as the acidic group.

Nimesulide is indicated in the treatment of a variety of painful inflammatory conditions including those associated with osteoarthritis, postoperative trauma, sports injuries, acute musculoskeletal disorders including tendonitis, tenosynovitis, sprains, strains and low back pain, ear, nose and throat disorders, dental surgery, bursitis/tendonitis, thrombophlebitis, pharyngitis and gynaecological disorders.

nimesulide 100mg drug interactions

Nimesulide is a leading NSAID’S drug with anti-inflammatory agent that differs from conventional nonsteroidal anti-inflammatory drugs both in structure and pharmacological profile.

Its main purpose is to treat acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea .

Nimesulide Tablet shows the result from pain within 15min from the drug intake

Nimesulide is available in the from of tablet, capsule and gel with the dosage of 100mg. Nimesulide is preffered for the shortest duration to minimize the risk of hepatotoxicity.

NImesulide tablet has a properties of analgesic (pain relief)and antipyretic (reduction of body temperature) 

The use of nimesulide in children under the age of 12 is contraindicated. Continuous use of nimesulide (more than 15 days) can cause the following side effects:
Diarrhea
Vomiting
Skin rash
Dizziness
Bitterness in mouth.

Nimesulide Actions and Uses

Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) which acts as a cyclooxygenase- 2 inhibitor. Which has become a leading NSAID in over 50 countries worldwide for the treatment of post-traumatic inflammation, acute musculoskeletal disorders including sprains, strains, tendinitis, tenosynovitis, low back pain, periarthritis (shoulder pain) and osteoarthritis (joint pains), stiffness. Nimesulide is a multi-factorial drug in controlling inflammation and pain. The adverse reaction profile of nimesulide is, in general, like that of other NSAIDs. It does, however, have relatively low occurrence of gastro-intestinal (GI) side effects. As for other NSAIDs the use of Nimesulide is preffered for the shortest duration necessary to control symptoms in patients with acute pain or primary dysmenorrhoea. Nimesulide is available in the form of gel, powder, capsules and tablets. Nimesulide also improves the skin tone and to increase in energy levels. Food, gender and advanced age have negligible effects on Nimesulide pharmacokinetics

Nimsulide mechanism of action for pain relief

Nimesulide drug was launched in Italy for the first time as Aulin and Mesulid in 1985 and is presently available in more than 50 countries worldwide with different trademarks. Nimesuilde is a pain killer NSAIDs drug is the best prescribed drug for treatment of acute pain, Primary dysmennorhea and also to treat degenerative joint disease Its multifactorial mode of action gives it a unique and broad action on inflammatory processes. It has superior gastrointestinal safety as compared to other NSAIDs. It is an analgesic and antipyretic in action, other than its anti inflammatory action." Nimesulide tablet shows pain relief from acute pain within 15 minutes from the drug intake.

Nimesulide 100mg tablet and its efficacy

Nimesulide is a anti-inflammatory agent with analgesic, antipyretic properties to treat acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea. As for other NSAIDs the use of nimesulide is recommended for the shortest duration necessary to control symptoms in patients with acute pain or primary dysmenorrhoea. It has low gastro-intestinal and renal toxicity. Nimesulide is available in the form of tablets, powder for dissolution in water, suppositories, mouth dissolving tablets and topical gel. Nimesulide shows the instant pain relief from acute pain (short-term pain)within 15 minitues of drug intake The use of nimesulide in children under the age of 12 is contraindicated. Continuous use of nimesulide (more than 15 days) can cause the following side effects: Diarrhea Vomiting Skin rash Dizziness Bitterness in mouth.

Nimesulide Analgesic action for pain relief

The efficacy and tolerability of Nimesulide in treatment of acute pain, osteoarthritis and primary dysmenorrhoea was consistently superior to placebo. Nimesulide drug for pain relief has a relatively rapid onset of the analgesic action for the patients suffering from acute pain which shows meaningful reductions observed within 15 minutes from drug intake. Nimesulide is a prescription-only drug and must be prescribed by a licensed physician after careful evaluation of the patient’s characteristics and needs. Nimesulide is available with the dosage of 100 mg for the tablets, and100 mg for granules for oral suspension, 200mg for the suppositories and 3% of gel. As for other NSAIDs the use of Nimesulide is preffered for the shortest duration necessary to control symptoms in patients with acute pain or primary dysmenorrhoea. The efficacy of Nimesulide was consistently superior to placebo with its particularly rapid onset action.

Nimesulide tablet dosage 100mg benefits

Nimesulide drug was launched in Italy for the first time as Aulin and Mesulid in 1985 and is presently available in more than 50 countries worldwide with different trademarks. Nimesulide is a relatively COX-2 selective, with analgesic and antipyretic properties. Its approved indications are the treatment of acute pain, Osteoarthritis and primary dysmenorrhoea. Nimesulide drug for pain relief has a relatively rapid onset of the analgesic action for the patients suffering from acute pain which shows meaningful reductions observed within 15 minutes from drug intake. Nimesulide is available with the dosage of 100 mg for the tablets, and 100 mg for granules for oral suspension, 200mg for the suppositories and 3% of gel. Nimesulide is preffered for the shortest duration necessary to control symptoms in patients.

Nimesulide Tablets for acute pain, degenerative joint disease

Nimesulide is a pain killer NSAIDs drug for the Nimesulide brand, it is the best prescribed drug for treatment of acute pain, Primary dysmennorhea and also to treat degenerative joint disease.


Nimesulide drug was launched in Italy for the first time as Aulin and Mesulid in 1985 and is presently available in more than 50 countries worldwide with different trademarks.


It has superior gastrointestinal safety with its multifactorial approach and gives a rapid action pain relief. The maximum duration and dose of a treatment course with nimesulide is 15 days, 100 mg twice a day, to minimize the risk of hepatotoxicity.


Nimesulide is contraindicated in patients with gastrointestinal bleeding ulcer, hypersensitive, Kidney and liver diseases

Nimesulide gel for Arthritis pain treatment

Nimesulide is a relatively COX-2 selective, with analgesic and antipyretic properties. Its approved indications are the treatment of acute pain, Osteoarthritis and primary dysmenorrhoea.

The tablet is available in various forms such as powder, suppositories, mouth dissolving tablets and topical gel.

Nimesulide gel is used to treat chronic and acute musculoskeletal disorders such as soft tissue injuries or non-articular rheumatic disorders, including discomfort in the muscles, tendonitis, back pain/ache, arthritis, tenosynovitis sprains, or strains.

The gel is prescribed to apply to the affected area for 2 to 4 times every day depending on the dimension of the affected size and response. Medicalcare ought to be reviewed after 4 weeks.

Nimesulide tablet pain reliever

Nimesulide is a prescribed non-steroidal anti-inflammatory drug with a multifactorial mode of action for the treatment of for post-traumatic inflammation, acute musculoskeletal disorders including sprains, strains, tendinitis, tenosynovitis, low back pain, periarthritis (shoulder pain) and osteoarthritis (joint pains), stiffness.

Nimesulide is a recently developed analgesic, antipyretic and anti-inflammatory agent that differs from conventional nonsteroidal anti-inflammatory drugs both in structure and pharmacological profile. 

Nimesulide is been available since 1985 and authorised in worldwide over 50 countries in different brands such as Sulide, Nimalox, Nimesil, Nimulid, Nicip, Nimcap, Nise, Sulidene and Zolan.

The tablet is available in various forms such as powder, suppositories, mouth dissolving tablets and topical gel. The prescribed dose and the duration prescribed is 100mg and the treatment should not be more than 15 days.

The dosageof NImesulide for various forms include tablets (100 mg), granules for oral suspension (100 mg), suppositories (200 mg) and gel (3%).

Nimesulide Pills

A non-steroidal anti-inflammatory most prescribed drug - Nimesulide that contains dose of 100mg and it’s used for treating acute (short-term) pain, painful osteoarthritis (swelling in the joints), and Primary dysmennorhea (Period Pains).

Nimesuilde is first launched in 1985and currently it’s on the market in worldwide of over 50 countries as orginal product with the trademarks of Nise, Nimopen-MP, Nic-Spas, Nimulid, Nicip, e.t.c.

This trademark also has several products by the brand name of Nimulid, Nise.

Popular NSAID drug Nimesulide is available in various forms including tablets, suppositories, soluble powders, and topical gels. 

Apart from its anti inflammatory it’s also an analgesic and antipyretic in action, and it’s an ethical medicine suggested to use medicine beneath authorised physician supervision. 

The drug is recommended to use for the age above 12 years and women ought to use the drug with caution throughout lactation and it is contraindicated during pregnancy. 

Nimesulide efficacy

Nimesulide is used for the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea 

The efficacy and tolerability of nimesulide was consistently superior to placebo.

Therapy appropriateness when using nimesulide is of outmost importance to safeguard patient’s health and guarantee the product’s therapeutic value.

As for other NSAIDs the use of nimesulide is recommended for the shortest duration necessary to control symptoms in patients with acute pain or primary dysmenorrhoea.

The maximum duration and dose of a treatment course with nimesulide is 15 days, 100 mg twice a day, to minimize the risk of hepatotoxicity.

Apart from its anti inflammatory it’s also an analgesic and antipyretic in action, and it’s an ethical medicine suggested to use medicine beneath authorised physician supervision.

Nimesulide – a multifactorial approach to inflammation and pain: scientific and clinical consensus, Current Medical Research and Opinion, Informa Healthcare

Nimesulide – a multifactorial approach to inflammation and pain: scientific and clinical consensus, Current Medical Research and Opinion, Informa Healthcare

Nimesulide Efficacy in pain

Nimesulide Efficacy in pain

Nimesulide dose for pain relief

The most prescribed Non-steroidal Anti-inflammatory pain killer drug- Nimesulide is available with the dosage of 100mg 

Nimesulide is indicated for the treatment of acute pain, Painful osteoarthritis (Swelling in the joints) and primary dysmenorrhoea. It been available since 1985 with a multifactorial mode of action.

The maximum duration and dose of a treatment course with nimesulide is recommended with the shortest period of 15 days, 100 mg twice a day, to minimize the risk of hepatotoxicity.

Nimesulide has superior gastrointestinal safety as compared to other NSAIDs. Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.

Nimesulide also improves the skin tone and to increase in energy levels. Food, gender and advanced age have negligible effects on Nimesulide pharmacokinetics.

Nimesulide pain tablets

Nimesulide is used for the treatment of post-traumatic inflammation, acute musculoskeletal disorders including sprains, strains, tendinitis, tenosynovitis, low back pain, periarthritis (shoulder pain) and osteoarthritis (joint pains), stiffness.

Nimesulide drug was launched in Italy for the first time as Aulin and Mesulid in 1985 and is presently available in more than 50 countries worldwide with different trademarks.

Nimesulide brands such as Sulide, Nimalox, Nimesil, Nimulid, Nicip, Nimcap, Nise, Sulidene and Zolan.
It has superior gastrointestinal safety as compared to other NSAIDs.

It is an analgesic and antipyretic in action. Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.

The maximum duration and dose of a treatment course with Nimesulide medicine is 15 days, 100 mg twice a day, to minimize the risk of hepatotoxicity.

Continuous use of Nimesulide may cause certain side effects like Diarrhea, vomiting, skin rash etc, It also preffered to use for the age above 12. Women should use the drug with caution during lactation and it is contraindicated during pregnancy.

Nimesulide also improves the skin tone and to increase in energy levels. Food, gender and advanced age have negligible effects on Nimesulide pharmacokinetics.

European Medicines Agency - - Nimesulide

European Medicines Agency - - Nimesulide: European Medicines Agency - - Nimesulide

Nimesulide forms

Nimesulide tablet is indicated for the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old with with analgesic and antipyretic properties.

Nimesulide is available in the form of tablets, powder for dissolution in water, suppositories, mouth dissolving tablets and topical gel.

Nimesulide dosage is of 100 mg for the tablets, and100 mg for granules for oral suspension, 200mg for the suppositories and 3% of gel.

The maximum duration prescribed for the tablet is15 days and the dosage to be used is 100mgs.

The use of nimesulide in children under the age of 12 is contraindicated. Continuous use of nimesulide (more than 15 days) can cause the following side effects:

• Diarrhea
• Vomiting
• Skin rash
• Dizziness
• Bitterness in mouth.

 Women should use the drug with caution during lactation and it is contraindicated during pregnancy