Nimesulide tablet dose

The main purpose of Nimesulide tablets is for the treatment of painful inflammatory conditions, back pain, dysmenorrhea, postoperative pain, osteoarthritis, and fever.

Oral dosage form in adults :100 mg and In children : 5 mg/kg/day in 2 or 3 divided doses. It is prescribed for the shortest duration.

Nimesulide has superior gastrointestinal safety as compared to other NSAIDs. Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.

Nimesulide tablet prevents cancer by inhibiting the proliferation of various types of cancer cells mainly via COX-2 independent mechanisms. It is also used for dry skin, to improve skin-tone,and to increase energy.

Nimesulide treatment  also brought about an immediate and significant improvement in over-all pain, exudation, oedema and headache.

Nimesulide Formulation and features

Nimesulide, a wide endorsed medicine pain relieving drug fits in with BCS classification II and show low and variable oral bioavailability.

Nimesulide (4-nitro-2-phenoxymethanesulfoanilide) may be a particular Cox-2 anti-inflammatory medication. This compund, a by-result of p-nitrophenyl methane arrangement sulfa, is structurally a solitary non-steroidal anti-inflammatorydrug. It has a place with particular COX-2inhibitors, with an intense pain relieving movement.

its shown as second line treatment for  acute pain, symptomatic treatment of excruciating degenerative joint ailment and first dysmenorrhoea.

It's conjointly utilized for the treatment of skin-tone, Heart illnesses and dry skin.

Nimesulide tablet features incorporate :

• Fast results
• Helpful and supportive
• No feature impacts
• Fast and quick effects

Use of Nimesulide 100mg- pill :

• Pain relieving and antipyretic.
• Rheumatic inflammatory sickness, degenerative joint ailment, elective perpetual joint issue treatment
• Musculo skeletal issue treatment
• Thrombophlebitis.
• Enhances skintone
• Heart Diseases
• Dry Skin
• Malignancy treatment

Nimesulide Medicine for Joint pain treatment

Joint ache influenced by osteoarthritis (OA) which is a gathering of mechanical abnormailities including debasement of joints, and NSAID’s – Nimesulide is most regularly used to treat agony connected with OA.

The primary symptom is agony, creating loss of capacity and regularly solidness. Osteoarthritis (OA) is brought about by aging joints, damage, and obesity. OA usually influences the hands, feet, spine, and the expansive weight bearing joints, for example, the hips and knees.


Nimesulide proved to be significantly more viable in giving symptomatic relief. Nimesulide speaks to a successful operator for the treatment of joint ache, with specific reference to the quick onset of its pain relieving impact.

It additionally utilized for the treatment of primary Dysmenorrhea, and Acute ache.

Nimesulide shows significant diminishments in pain and irritation observed in 15 minutes with pain relieving and antipyretic properties.

Nimesulide Drug Composition

Nimesulide, a wide proposed drug pain relieving medication has a place with sulfonanilide class II and show low and variable oral bioavailability. Nimesulide tablets is generally utilized in inflammatory pain.

Nimesulide (4-nitro-2-phenoxymethanesulfoanilide) is a particular Cox-2 calming medication. This intensify, a by-result of p-nitrophenyl methane arrangement sulfa, is structurally a particular non-steroidal mitigating medication.

It groups antihistaminic, pain relieving and antipyretic properties.

Nimesulide tablet experiences extensive biotransformation and has a generally fast onset of activity, with significant diminishments in agony and irritation saw inside 15 minutes from medication consumption.

Nimesulide is likewise being broadly utilized for anticancer and antiviral operators, and dental surgery.

Nimesulide Synthesis

Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties which, preferentially inhibits the enzyme cyclooxygenase-2 (COX-2)

It has better gastro-intestinal tolerability among other NSAIDs in its class. Its approved indications are the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea, sports injuries etc.

A variety of new nimesulide derivatives were synthesized through incorporation of a 5-LOX pharmacophore into Nimesulide followed with some structural modifications. which were then characterized for dual enzyme inhibitors for these two types of enzymes (Cyclooxygenase-½ (COX-½) and 5-lipoxygenase (5-LOX) )

Clinically it has proven that it supports a particularly good profile in terms of gastrointestinal tolerability.

Nimesulide Gel

Nimesulide tablets is available in gel formulation and applied mainly for topical pain management.

Nimesulide transdermal gel is a well tolerated novel hydroalcoholic microcarrier based drug delivery system with penetration enhancer. This is cause of superior efficacy of Nimesulide Transdermal Gel.

 

Nimesulide gel is indicated for a variety of conditions characterized by pain, inflammation and stiffness, such as osteoarthritis, periarthritis, post-traumatic or acute musculoskeletal disorders including tendinitis, tenosynovitis, sprains, strains and low back pain. It Functions by inhibiting particular nerve impulses sent from the periphery to your central system.

 

Nimesulide is a non-steroidal anti-inflammatory (NSAID) agent which also possess analgesic properties. The product has been formulated using a novel combination of solvents for solubilization of Nimesulide.

 

Nimesulide exhibited better efficacy it also demonstrated faster onset of action. Significant concentration of Nimesulide could be detected in the blood within 30 minutes of treatment and persisted for 8 hours post treatment

Nimesulide Tablets and it's various Forms

The best prescribed Nimesulide tablet is used for the treatment of acute pain, Primary dysmennorhea and also to treat degenerative joint disease.

Apart from tablet the drug- Nimesulide is also available in various forms such as in the form of Gell, powder, and suppositories with the dosage of 100 mg for tablets, 100 mg for granules for oral suspension, 200mg for suppositories and 3% of gel.

Nimesulide is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF).

Nimesulide transdermal gel is a well tolerated novel hydroalcoholic microcarrier based drug delivery system with penetration enhancer.

 

Nimesulide gel is indicated for a variety of conditions characterized by pain, inflammation and stiffness, such as osteoarthritis, periarthritis, post-traumatic or acute musculoskeletal disorders including tendinitis, tenosynovitis, sprains, strains and low back pain.
It’s also available in various brand names of Sulide, Nimalox, Nimesil, Nimulid, Nicip, Nimcap, Nise, Sulidene and Zolan e.t.c. which is available in more than 50 countries world wide.

Comparision of Nimesulide and Paracetamol Tablets

The effectivity and tolerability of nimesulide were compared with those of paracetamol in an exceedingly non blind randomized study that recruited 110 kids (64 males, 46 females; aged 3 to 6 years) with inflammation of the higher tract and fever.

Nimesulide suspension (1.5 mg/kg three times daily) or paracetamol sirup (10 mg/kg four times daily) were administered orally till fever resolved. blood heat was recorded and native pain and general discomfort assessed.

Nimesulide was as effective as paracetamol in reducing fever, local pain, and general discomfort. Nimesulide therefore appears to be a minimum of as effective as paracetamol in terms of antipyretic and anti inflammatory activity in children with inflammation of the upper tract and fever.

The other recent study with the patients aged between twelve and sixty years on the premise of analgesic effectiveness and tolerability has well-tried that the analgesic results of Nimesulide had a faster onset (<15 minutes) and was stronger (based on patient opinion). And were well tolerated.

Nimesulide is suggested for the shortest length necessary to regulate symptoms in patients with acute pain or primary dysmenorrhoea.

Nimesulide Tablet Indications

Anti-inflammatory Analgesics tablet – Nimesulide is very much required for the quick treatment of severe muscular pains and inflammatory problems. NImesulide tablets is available in different countries in the world.

Information:

Nimesulide is indicated in painful inflammatory conditions associated with musculoskeletal system, dysmenorrhoea, Thrombophlebitis, dental pain and in ENT inflammation.

Features:

• Desirable results
• Helpful and beneficial
• No side effects
• Fast and quick effects

Nimesulide 100mg Tablets/granules should be used for the shortest possible duration, as required by

the clinical situation.

 

Indications:

 

Tablets or Granules: 100 mg twice a day after meals

400 mg nimesulide-beta-cyclodextrin Tablets or Granules: 400 mg (= 100 mg nimesulide)

twice a day after meals

Suppositories: 200 mg twice a day

Nimesulide Drug Composition

Nimesulide, a wide recommended medication analgesic drug belongs to sulfonanilide class II and exhibit low and variable oral bioavailability.

Nimesulide (4-nitro-2-phenoxymethanesulfoanilide) is a selective Cox-2 anti-inflammatory drug. This compound, a by-product of p-nitrophenyl methane series sulfa, is structurally a singular non-steroidal anti-inflammatory drug.

It posses antihistaminic, analgesic and antipyretic properties.

NImesulide medication is used in the treatment for acute pain, symptomatic treatment of painful degenerative joint disease and first dysmenorrhoea.

It’s conjointly used for the treatment of skin-tone, Heart diseases, Cancer and dry skin. It likewise gives Quick and quick impacts with its rapid pain relief. It is also used for increasing energy

Nimesulide Tablet for the treatment of Cancer

Cancer, otherwise called a dangerous tumor or harmful neoplasm, is a gathering of ailments including irregular cell development with the possibility to attack or spread to different parts of the body. Cyclooxygenase-2 (COX-2) inhibitor Nimesulide represses the expansion of different sorts of malignancy cells mainly through COX-2 independent mechanisms, which makes it a good lead compound for hostile to disease drug improvement.

There are more than 100 sorts of cancer, including breast tumor, skin malignancy, lung disease, colon malignancy, prostate malignancy, and lymphoma. Manifestations fluctuate relying upon the sort.

An arrangement of new Nimesulide analogs were synthesized focused around the structure–function examination produced previously. It showed exceptionally strong hostile to malignancy movement.

Fundamentally supress the development of numerous growth. By using Nimesulide the sizes of the colon carcinomas were additionally diminished.

Pharmacokinetic studies exhibit the great bioavailability of the compound. A set of non-COX-2 dynamic Nimesulide anti-cancer derivatives were synthesized. It acts as a decent lead compound for against tumor drug advanceme

Osteoarthritis pain tablet - Nimesulide

Joint pain affected by osteoarthritis (OA) which is a group of mechanical abnormalities involving degradation of joints, and NSAIDs - Nimesulide is most commonly used to treat pain associated with OA.

The main symptom is pain, causing loss of ability and often stiffness. Osteoarthritis (OA) is caused by aging joints, injury, and obesity. OA commonly affects the hands, feet, spine, and the large weight bearing joints, such as the hips and knees,

cyclo-oxygenase (COX)-2-selective inhibitors have been proved to have certain advantages over non-selective NSAIDs and have been increasingly used for pain management in patients with OA.

Nimesulide proved to be significantly more effective in providing symptomatic relief. Nimesulide represents an effective agent for the treatment of joint pain, with particular reference to the rapid onset of its analgesic effect.

It also used for the treatment of primary Dysmenorrhea, and Acute pain.

Nimesulide shows meaningful reductions in pain and inflammation observed within 15 minutes with its analgesic and antipyretic properties.

Nimesulide tablet formula and ts prupose

Nimesulide, a wide prescribed medication analgesic drug belongs to BCS category II and exhibit low and variable oral bioavailability.

Nimesulide (4-nitro-2-phenoxymethanesulfoanilide) may be a selective Cox-2 anti-inflammatory drug drug. This compound, a by-product of p-nitrophenyl methane series sulfa, is structurally a singular non-steroidal anti-inflammatory drug.

It belongs to selective COX-2inhibitors, with a potent analgesic activity.
it’s indicated as second line treatment for acute pain, symptomatic treatment of painful degenerative joint disease and first dysmenorrhoea.

It’s conjointly used for the treatment of skin-tone, Heart diseases and dry skin. It also gives Quick and fast effects with its rapid pain relief.

It reduces heart diseases, and cancer, and also improves skin tone.

Nimesulide Medicines for pain relief

The European Medicines Agency has completed a review of the safety and effectiveness of medicines containing nimesulide (capsules, tablets, suppositories and powder or granules for oral suspension).

It has concluded that NImesulide has great benefits for the treatment of acute pain and primary dysmenorrhoea. It issued a recommendation that it shouldbe used for the shortest duration (<15days)

It is also used for dry skin and skin tome

Usage of Nimesulide 100mg- Tablet

• Analgesic and antipyretic.
• Rheumatoid arthritis, osteoarthritis, other degenerative joint disorders.
• Musculo skeletal disorders.
• Thrombophlebitis.

 Nimesulide tablet has great analgesic and antipyretic properties which is nothing but relief from pain and reduction of body temperature.

Nimesulide Tablet Synthesis

Nimesulide is a COX-2 selective drug which has the properties of antiinflammatory and antihistaminic, it also possesses analgesic properties.

Apart for the treatment of acute pain, osteoarthritis and primary dysmenorrhoea. Nimesulide is also being widely used for anticancer and antiviral agents.

A variety of new nimesulide derivatives were synthesized through incorporation of a 5-LOX pharmacophore into Nimesulide followed with some structural modifications.

Nimesulide is preffered for the shortest duration necessary to control symptoms in patients with acute pain or primary dysmenorrhoea. The efficacy of Nimesulide was consistently superior to placebo with its particularly rapid onset action.

Nimesulide is ought there in various forms like powder/granules, gel, and suppositories.

Clinically it has proven that it supports a particularly good profile in terms of gastrointestinal tolerability.

Nimesulide tablet brands

NSAIDs tablet Nimesulide is been available since 1985 and authorised with different trade names in worldwide over 50 countries.

Main purpose of using Nimesulide drug is to:

• Treat acute pain
• Treat degenerative joint disease
• Treat primary dysmenorrhoea in adolescents and adults above 12 years old
• treat all types of pains resulting from sports injury, depression etc.

Nimesulide is available in various brands such as Sulide, Nimalox, Nimesil, Nimulid, Nicip, Nimcap, Nise, Sulidene and Zolan.

Nimulid is indicated for post-traumatic inflammation, acute musculoskeletal disorders including sprains, strains, tendinitis, tenosynovitis, low back pain, periarthritis (shoulder pain) and osteoarthritis (joint pains), stiffness.

Nise (100 mg) – Tablet, contains Generic Medicine Nimesulide- 100 mg. which is a non-steroidal anti-inflammatory drug (NSAID) with Analgesic and antipyretic properties

Nimesulide Tablet Efficacy and Safety

The abilities of NSAID’s drug nimesulide to inhibit COX-2 preferentially and to exert other novel anti-inflammatory actions are consistent with good efficacy and safety and is consistently superior to placebo.

Nimesulide has proven that it gives rapid pain relief with its analgesic activity which shows relief from pain relief and inflammation within 15 minutes from drug intake.

Nimesulide must be prescribed by a licensed physician as second line treatment in the approved indications and in compliance with the recommendations

Daily dose is 100mg twice-a-day.

 As for other NSAIDs the use of nimesulide is recommended for the shortest duration necessary to control symptoms in patients with acute pain or primary dysmenorrhoea.

Nimesulide Tablet Uses

Nimesulide is a nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, anti-pyretic, and analgesic properties. It inhibits prostaglandin synthetase/cyclooxygenase, which limits prostaglandin production.

Nimesulide is required for rapid pain relief from severe muscular pains and inflammatory problems. Which gives relief from pain in 15 min.

Nimesulide is indicated in painful inflammatory conditions associated with musculoskeletal system, dysmenorrhoea, Thrombophlebitis, dental pain and in ENT inflammation.

The various inflammatory conditions such as tonsillitis, pharyngitis, stomatitis, rheumatoid arthritis, osteoarthritis, low back pain etc., can be treated by Nimesulide tablet.

Apart from that, It's also prescribed for the treatment of Skin tone, Heart disease and dry skin.

Nimesulide tablet is available in the form of granules, Gel, and Suppositories.

Nimesulide 100mg Tablets/granules should be used for the shortest possible duration, as required by
the clinical situation.

This medicine is suggested to use beneath authorized physician supervision.