Nimesulide efficay in pain

The abilities of NSAID’s drug nimesulide to inhibit COX-2 preferentially and to exert other novel anti-inflammatory actions are consistent with good efficacy and safety with highly effective in reducing pain, inflammation and also helps in better penetration of the antibiotics.

Nimesulide posses analgesic properties with multifactorial mode of action for the treatment of musculoskeletal system, dysmenorrhoea, and acute pain .

It also undergoes extensive biotransformation. The recent study on the basis of analgesic activity of nimesulide has proved that Nimesulide had a quicker onset which shows relief from pain relief and inflammation within 15 minutes from drug intake.

Nimesulide is recommended for the shortest duration necessary to control symptoms in patients with acute pain or primary dysmenorrhoea.

Nimesulide is available in distinctive brands, for instance, Sulide, Nimalox, Nimesil, Nimulid, Nicip, Nimcap, Nise, Sulidene, Zolan and etc.

Nimesulide efficacy

Nimesulide is used for the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea.

The efficacy and tolerability of nimesulide was consistently superior to placebo.

Therapy appropriateness when using nimesulide is of outmost importance to safeguard patient’s health and guarantee the product’s therapeutic value.

As for other NSAIDs the use of nimesulide is recommended for the shortest duration necessary to control symptoms in patients with acute pain or primary dysmenorrhoea.

The abilities of NSAID’s drug Nimesulide to inhibit COX-2 preferentially and to exert other novel anti-inflammatory actions are consistent with good efficacy and safety with highly effective in reducing pain, inflammation and also helps in better penetration of the antibiotics.

Nimesulide posses analgesic properties with multifactorial mode of action for the treatment of musculoskeletal system, dysmenorrhoea, and acute pain.

It also undergoes extensive biotransformation. The recent study on the basis of analgesic activity of Nimesulide has proved that it has a quicker onset which shows relief from pain relief and inflammation within 15 minutes from drug intake.

Nimesulide solubility

NSAID drug NImesulide has proven benefits in the treatment of Acute (short term) pain, Painful osteoarthritis (Swelling in the joints) and Primary dysmennorhea (Period Pains).

Nimesulide is available in various forms like Nimesulide Tablets, Nimesulide Powder, Nimesulide Gell, suppositories etc.

Nimesulide is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF). 

nimesulide is an effective and safe therapeutic choice for the treatment of various painful inflammatory conditions, with a rapid onset of analgesic activity.

Nimesulide is a unique non- steroidal anti-inflammatory drug that acts specifically on cyclo-oxygenase-2 and does not affect cyclo-oxygenase-1. Hence, it exerts its anti-inflammatory action characteristics of non- steroidal anti-inflammatory drug. Solubility of Nimesulide Increased on solubilization of drug in semi-polar solvents and non-ionic surfactants.

Solubility of Nimesulide was studied using different cosolvent mixtures and various classes of non-ionic surfactant. Solubility increased drastically (>70 mg/rnl) when polyethylene glycol 300 and polyethylene glycol 400 were used as solvents.

The quick dissolving tablets of Nimesulide contains superdisintegrants, that accelerates the disintegration of tablets by virtue of their ability to soak up great deal of water once exposed to binary compound surroundings.

Nimesulide tablet for Bp

Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory pain killer drug(NSAID) prescribed for treatment of acute pain, Primary dysmennorhea and degenerative joint disease.

This medicine has potent analgesic, anti pyretic and anti-inflammatory activity on oral & rectal administration.

Nimesulide BP 100mg prevents the release of prostaglandins which is responsible for inflammation, pain & fever.

Nimesulide is a selective inhibitor of prostaglandin synthesis but appears to exert its therapeutic effect by a variety of other mechanisms like inhibition of platelet-activating factor (PAF), tumour necrosis factor-alpha (TNF alpha,) Proteinase & histamine etc.

Nimesulide is Indicated in reducing pain, fever and inflammatory symptoms of:

• Chronic arthritis
• Osteo arthritis
• Otorhinolary diseases
• Soft tissues and oral cavity inflammation
• Dysmenorrhoea
• Thrombosis
• Urogenital disease
• Postoperative pain states
• Sports injuries

Nimesulide tablet purpose

NSAIDs prescribed painkiller drug- Nimesulide tablet is used for the treatment of acute pain, Primary dysmennorhea and also to treat degenerative joint disease.

Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.

Nimesulide also has superior gastrointestinal safety as compared to other NSAIDs.

NImesulide is available in the dosage of 100 mgs for tablets, 100 mg for granules for oral suspension, 200mg for suppositories and 3% of gel.

The prescribed duration for the tablet to use is15 days and the dosage to be used is 100mgs.

The main purpose of Nimesulide tablets is for the treatment of painful inflammatory conditions, back pain, dysmenorrhea, postoperative pain, osteoarthritis, and fever.

Additionally it also helps to reduce cancer and heart problem. It is also used for dry skin, to improve skin-tone,and to increase energy,

Nimesulide tablet prevents cancer by inhibiting the proliferation of various types of cancer cells mainly via COX-2 independent mechanisms.

Nimesulide, a wide prescribed medication analgesic drug belongs to BCS category II and exhibit low and variable oral bioavailability. It posses properties of anti-inflammatory, analgesic, antipyretic and antihistaminic. It has a particularly good profile to support in terms of gastrointestinal tolerability.

Nimesulide drug interactions

Nimesulide is a prescribed analgesic, antipyretic and anti-inflammatory agent that differs from conventional nonsteroidal anti-inflammatory drugs both in structure and pharmacological profile.

Its approved indications are the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults.

it’s an ethical medicine suggested to use medicine beneath authorised physician supervision.

Nimesulide is a recently developed analgesic, antipyretic and anti-inflammatory agent that differs from conventional nonsteroidal anti-inflammatory drugs both in structure and pharmacological profile. Since nimesulide may be prescribed for patients receiving concomitant medication, the propensity for drug interactions exists.

Nimesulide is also available in the form of dissolving tablets, granules for oral suspension, and Gel. The fast dissolving tablets of Nimesulide contains superdisintegrants, which accelerates the disintegration of tablets by virtue of their ability to absorb large amount of water when exposed to aqueous Environment.

Major interactions involving interference with drug metabolism have not been described with Nimesulide.

A marginal decrease in plasma theophylline levels (without changes in respiratory function tests) has been described after addition of Nimesulide to chronic theophylline therapy. Nimesulide is available in the market with the dosage of 100Mg.

Nimesulide for instant pain relief

Pain relief drug nimesulide which shows the instant pain relief from acute pain (short-term pain)within 15 minitues of drug intake

Nimesulide is a prescription-only drug and must be prescribed by a licensed physician after careful evaluation of the patient’s characteristics and needs.
Clinical studies have been carried out in a wide variety of acute inflammatory and painful conditions with the aim of evaluating the analgesic activity of nimesulide in comparison to placebo and to some of the most common NSAIDs.
In these studies, it is observed that the efficacy of nimesulide was consistently superior to placebo with a particularly fast onset of the analgesic in action.

The rapid action shows the immediate relief within the 15 min from the drug intake for the acute pain.

It must be used under supervision by a doctor in accordance with the approved indications and in compliance with the recommendations .The overall safety profile of nimesulide is in line with that of all other NSAIDs. As with all drugs, it must be used in the most appropriate way to guarantee its best therapeutic value.

Nimesulide tablet indications

Anti-inflammatory Analgesics tablet – Nimesulide is very much required for the quick treatment of severe muscular pains and inflammatory problems. Nimesulide tablets is available in different countries in the world.

Nimesulide is indicated in painful inflammatory conditions associated with musculoskeletal system,
dysmenorrhoea, Thrombophlebitis, dental pain and in ENT inflammation.

Features:

• Desirable results
• Helpful and beneficial
• No side effects
• Fast and quick effects

Nimesulide 100mg Tablets/granules should be used for the shortest possible duration, as required by

the clinical situation.

This medicine is for the most part used as an issue of the treatment of inflammatory torment and also used for postoperative trauma,sport injuries, acute musculoskeletal disorders

Dosage:

 

Tablets or Granules: 100 mg twice a day after meals

400 mg nimesulide-beta-cyclodextrin Tablets or Granules: 400 mg (= 100 mg nimesulide)

twice a day after meals

Suppositories: 200 mg twice a day

Indications:

Osteoarthritis

Low back pain

Sports injury

Dental pain

Moderative pain &fever

dysmenorrhea.

Nimesulide for instant pain relief

Pain relief drug nimesulide which shows the instant pain relief from acute pain (short-term pain)within 15 minitues of drug intake

Nimesulide is a prescription-only drug and must be prescribed by a licensed physician after careful evaluation of the patient’s characteristics and needs.

It must be used under supervision by a doctor in accordance with the approved indications and in compliance with the recommendations .The overall safety profile of nimesulide is in line with that of all other NSAIDs. As with all drugs, it must be used in the most appropriate way to guarantee its best therapeutic value.

Clinical studies have been carried out in a wide variety of acute inflammatory and painful conditions with the aim of evaluating the analgesic activity of nimesulide in comparison to placebo and to some of the most common NSAIDs.

In these studies, it is observed that the efficacy of nimesulide was consistently superior to placebo with a particularly fast onset of the analgesic in action.

The rapid action shows the immediate relief within the 15 min from the drug intake for the acute pain.

Nimesulide dosage

Nimesulide is a Non steroidal anti inflammatory drug (NSAID) and targets COX-2 an enzyme responsible for inflammation & pain.

The nimesulide is preferably used in the composition in an amount of 0.1-5% by weight, more preferably in an amount of 0.1-3% by weight, most preferably in an amount of around 1 % by weight of the composition.

This medication is for the most part used as an issue of the treatment of inflammatory torment and also used for postoperative trauma, sports injuries, acute musculoskeletal disorders.

Nimesulide have pain relieving and antipyretic properties which, specially restrains the protein cyclooxygenase-2 (COX-2) and has better gastro-intestinal bearableness in addition to different Nsaids in its class.

Dosage:

The usual dose is 100mg twice a day.
Children: 5mg/kg of body weight in 2 or 3 divided doses.

The minimum effective dose should be used for the shortest duration to reduce the undesirable effects.

The maximum duration of a treatment course with Nimesulide is 15 days.

Nimesulide 100mg Tablets/granules should be used for the shortest possible duration, as required by the clinical situation.

Nimesulide Tablet Efiicacy

The abilities of NSAID’s drug Nimesulide to inhibit COX-2 preferentially and to exert other novel anti-inflammatory actions are consistent with good efficacy and safety with highly effective in reducing pain, inflammation and also helps in better penetration of the antibiotics.

Nimesulide posses analgesic properties with multifactorial mode of action for the treatment of musculoskeletal system, dysmenorrhoea, and acute pain.

It also undergoes extensive biotransformation. The recent study on the basis of analgesic activity of Nimesulide has proved that it has a quicker onset which shows relief from pain relief and inflammation within 15 minutes from drug intake.

Nimesulide is recommended for the shortest duration necessary to control symptoms in patients with acute pain or primary dysmenorrhoea.

Nimesulide Efficacy

The abilities of NSAID’s drug nimesulide to inhibit COX-2 preferentially and to exert other novel anti-inflammatory actions are consistent with good efficacy and safety with highly effective in reducing pain, inflammation and also helps in better penetration of the antibiotics.

Nimesulide posses analgesic properties with multifactorial mode of action for the treatment of musculoskeletal system, dysmenorrhoea, and acute pain .

It also undergoes extensive biotransformation. The recent study on the basis of analgesic activity of nimesulide has proved that Nimesulide had a quicker onset which shows relief from pain relief and inflammation within 15 minutes from drug intake.

Nimesulide is recommended for the shortest duration necessary to control symptoms in patients with acute pain or primary dysmenorrhoea.

Nimesulide Gel

Nimesulide tablets is available in gel formulation and applied mainly for topical pain management.

Nimesulide transdermal gel is a well tolerated novel hydroalcoholic microcarrier based drug delivery system with penetration enhancer. This is cause of superior efficacy of Nimesulide Transdermal Gel.

 

Nimesulide gel is indicated for a variety of conditions characterized by pain, inflammation and stiffness, such as osteoarthritis, periarthritis, post-traumatic or acute musculoskeletal disorders including tendinitis, tenosynovitis, sprains, strains and low back pain. It Functions by inhibiting particular nerve impulses sent from the periphery to your central system.

 

Nimesulide is a non-steroidal anti-inflammatory (NSAID) agent which also possess analgesic properties. The product has been formulated using a novel combination of solvents for solubilization of Nimesulide.

 

Nimesulide exhibited better efficacy it also demonstrated faster onset of action. Significant concentration of Nimesulide could be detected in the blood within 30 minutes of treatment and persisted for 8 hours post treatment

Osteoarthritis pain tablet - Nimesulide

Joint pain affected by osteoarthritis (OA) which is a group of mechanical abnormalities involving degradation of joints, and NSAIDs - Nimesulide is most commonly used to treat pain associated with OA.

The main symptom is pain, causing loss of ability and often stiffness. Osteoarthritis (OA) is caused by aging joints, injury, and obesity. OA commonly affects the hands, feet, spine, and the large weight bearing joints, such as the hips and knees,

cyclo-oxygenase (COX)-2-selective inhibitors have been proved to have certain advantages over non-selective NSAIDs and have been increasingly used for pain management in patients with OA.

Nimesulide proved to be significantly more effective in providing symptomatic relief. Nimesulide represents an effective agent for the treatment of joint pain, with particular reference to the rapid onset of its analgesic effect.

It also used for the treatment of primary Dysmenorrhea, and Acute pain.

Nimesulide shows meaningful reductions in pain and inflammation observed within 15 minutes with its analgesic and antipyretic properties.

Nimesulide Tablet Efficacy and Safety

The abilities of NSAID’s drug nimesulide to inhibit COX-2 preferentially and to exert other novel anti-inflammatory actions are consistent with good efficacy and safety and is consistently superior to placebo.

Nimesulide has proven that it gives rapid pain relief with its analgesic activity which shows relief from pain relief and inflammation within 15 minutes from drug intake.

Nimesulide must be prescribed by a licensed physician as second line treatment in the approved indications and in compliance with the recommendations

Daily dose is 100mg twice-a-day.

 As for other NSAIDs the use of nimesulide is recommended for the shortest duration necessary to control symptoms in patients with acute pain or primary dysmenorrhoea.

Nimesulide Tablet Uses

Nimesulide is a nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, anti-pyretic, and analgesic properties. It inhibits prostaglandin synthetase/cyclooxygenase, which limits prostaglandin production.

Nimesulide is required for rapid pain relief from severe muscular pains and inflammatory problems. Which gives relief from pain in 15 min.

Nimesulide is indicated in painful inflammatory conditions associated with musculoskeletal system, dysmenorrhoea, Thrombophlebitis, dental pain and in ENT inflammation.

The various inflammatory conditions such as tonsillitis, pharyngitis, stomatitis, rheumatoid arthritis, osteoarthritis, low back pain etc., can be treated by Nimesulide tablet.

Apart from that, It's also prescribed for the treatment of Skin tone, Heart disease and dry skin.

Nimesulide tablet is available in the form of granules, Gel, and Suppositories.

Nimesulide 100mg Tablets/granules should be used for the shortest possible duration, as required by
the clinical situation.

This medicine is suggested to use beneath authorized physician supervision.

Nimesulide Tablet in pain

Nimesuilde is a pain killer NSAIDs drug is the best prescribed drug for treatment of acute pain, Primary dysmennorhea and also to treat degenerative joint disease.

Nimesulide drug has multifactorial mode of action which, gives a unique and broad action on inflammatory processes. It also has superior gastrointestinal safety as compared to other NSAIDs. It is an analgesic and antipyretic in action, other than its anti inflammatory action.

Unlike, other NSAIDs, the chemical structure of nimesulide does not contain a carboxylic group but a sulfonanilide moiety as the acidic group.

Apart from tablet the drug- Nimesulide is also available in various forms such as in the form of Gell, powder, and suppositories. It’s also available in various brand names of Sulide, Nimalox, Nimesil, Nimulid, Nicip, Nimcap, Nise, Sulidene and Zolan e.t.c.

The Nimulid Transgel a brand from Nimesulide Transdermal Gel is indicated for post-traumatic inflammation, acute musculoskeletal disorders including sprains, strains, tendinitis, tenosynovitis, low back pain, periarthritis (shoulder pain) and osteoarthritis (joint pains), stiffness.

As with all drugs, therapy appropriateness when using nimesulide is of outmost importance to safeguard patient’s health and guarantee the product’s therapeutic value.

NImesulide is available in the dosage of 100 mgs for tablets, 100 mg for granules for oral suspension, 200mg for suppositories and 3% of gel. And the prescribed duration to use is for 15 days. 

Nimesulide Tablets Purpose

The main purpose of using Nimesulide 

• To treat acute pain 
• To treat osteoarthritis 
• To treat primary dysmenorrhoea in adolescents and adults above 12 years old.
• Increasing Energy
• Improving Skin Tone
• Heart Disease
• Dry Skin
• And are non-FDA reviewed or approved, natural alternatives, to use for , Heart Disease, and Dry Skin.

Nimesulide is a non-selective non-steroidal anti-inflammatory drug (NSAID) used for the treatment of Acute pain which, is a short-term pain, painful osteoarthritis (swelling in the joints), primary dysmenorrhoea (period pains). 

Medicines containing nimesulide have been available since 1985 and are authorised in a number of Member States. They are only available with a prescription.

  
Nimesulide drug is also known as nice tablet. It has superior gastrointestinal safety

Nimesulide 100mg tablet and its efficacy

Nimesulide is a anti-inflammatory agent with analgesic, antipyretic properties to treat acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea. As for other NSAIDs the use of nimesulide is recommended for the shortest duration necessary to control symptoms in patients with acute pain or primary dysmenorrhoea. It has low gastro-intestinal and renal toxicity. Nimesulide is available in the form of tablets, powder for dissolution in water, suppositories, mouth dissolving tablets and topical gel. Nimesulide shows the instant pain relief from acute pain (short-term pain)within 15 minitues of drug intake The use of nimesulide in children under the age of 12 is contraindicated. Continuous use of nimesulide (more than 15 days) can cause the following side effects: Diarrhea Vomiting Skin rash Dizziness Bitterness in mouth.

Nimesulide tablet dosage 100mg benefits

Nimesulide drug was launched in Italy for the first time as Aulin and Mesulid in 1985 and is presently available in more than 50 countries worldwide with different trademarks. Nimesulide is a relatively COX-2 selective, with analgesic and antipyretic properties. Its approved indications are the treatment of acute pain, Osteoarthritis and primary dysmenorrhoea. Nimesulide drug for pain relief has a relatively rapid onset of the analgesic action for the patients suffering from acute pain which shows meaningful reductions observed within 15 minutes from drug intake. Nimesulide is available with the dosage of 100 mg for the tablets, and 100 mg for granules for oral suspension, 200mg for the suppositories and 3% of gel. Nimesulide is preffered for the shortest duration necessary to control symptoms in patients.