Nimesulide Granules

Nimesulide Granules is non-steroidal anti-inflammatory drugs, indicated for the treatment of juvenile chronic arthritis, postoperative pain, acute pain after trauma and primary dysmenorrhea.

Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties.

Its approved indications are the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old.
Active ingredients: nimodipine. Indication: nimesulide granules is non-steroidal anti-inflammatory drugs, indicated for the treatment of juvenile chronic arthritis, postoperative pain, acute pain after trauma and primary dysmenorrhea. Packaging: 1g / sack; 6, 8, 10 sacks / pack. Contact us for more information.

usage and consumption: oral, the goods only for adults only, a 50 mg to 100 mg daily twice postprandial taking. In accordance with the severity of the conditions and the needs of the patients can be increased to 0.2g, the second service.
elderly patients of the medication should strictly comply with the provisions of doctors. Doctors can reduce under appropriate in the circumstances listed above dosage.

Nimesulide has a potent Anti-Inflammatory action.It behaves as a competetive inhibitor of histamine release in-vivo and in-vitro, hence posseses antihistaminic and antiallergic properties.

Indications: Nimesulide is indicated in painful inflammatory conditions associated with musculoskeletal system, dysmenorrhoea, Thrombophlebitis, dental pain and in ENT inflammation. Absorption Well absorbed from GI tract following oral admin. Peak plasma levels:1-3 hours. With bid admin of 100 mg, steady-state is achieved within 24-36 hours.

Routes of Administration and Dosage: Oral dosage form in adults :100 mg b.i.d In children : 5 mg/kg/day in 2 or 3 divided doses.

Nimesulide Gel Uses

Nimesulide is available in the market in various forms including tablets (100 mg), granules for oral suspension (100 mg), suppositories (200 mg) and gel (3%).

Nimesulide Gel should be applied to the affected area, for 2 to 4 times every day.

Gel is used for the treatment of chronic and acute musculoskeletal disorders including discomfort in the muscles, tendonitis (cord), back pain/ache, arthritis, tenosynovitis(swelling in tendon) sprains, or strains.

Some patients were analysed for assessing the efficacy and safety of this gel. This studies results in better relief from pain and inflammation(redness/ swelling in a part of a body) parameters in more number of patients with Nimesulide Gel.

Nimesulide exhibited better efficacy, and demonstrated faster onset of action. Nimesulide provides significant analgesic (painrelief) activity when applied topically. Peak analgesic effect was observed at 120 min from treatment.

It functions by inhibiting particular nerve impulses sent from the periphery to your central system, leading to a decrease of sensitivity from the kinds of symptoms associated with the conditions above.

Non-steroidal anti-inflammatory drug – Nimesulide

Nimesuilde is a pain killer Non-steroidal medicinal drug (NSAIDs) with a complex mode of action, characterized by a quick onset of analgesic activity.

The anti-inflammatory drug mechanism of Nimesulide should only be prescribed as second line treatment. The decision to prescribe nimesulide should be based on assessment of the individual patient’s overall risks.

Main purpose of using this drug is to treat acute pain, to treat degenerative joint disease, to treat primary dysmenorrhoea in adolescents and adults above 12 years old, it is used for treatment of all types of pains resulting from sports injury, depression etc.

Additionally it helps in increasing energy, improve skin tone, and to cure Heart diseases, and also helpful for dry skin and is usually recommended for the shortest period necessary to control symptoms in patients with pain

Nimesulide has superior gastrointestinal safety as compared to other NSAIDs.
Its multifactorial mode of action gives a unique and broad action on inflammatory processes.

Nimesulide is also offered in the form of gell, powder which is now available in worldwide of more than 50 countries. It also available in different trademarks like Nimesil, Nimulid, Nise e.t.c

Nimesulide Brands

Nimesulide is a non-steroidal anti-inflammatory analgesic and antipyretic drug (NSAID). It is a selective cyclooxygenase - 2 (COX -2) enzyme inhibitor and is effective in the treatment of a wide range of inflammatory and painful conditions including osteoarthritis, extra-curricular disorders such as tendonitis and bursitis, post-operative pain and primary dysmenorrhoea.

Nimesulide gel preparations for localized topical application are indicated for the treatment of symptomatic relief of pain associated with sprains and acute traumatic tendinitis.

The most powerfull painkiller NSAIDs tablet Nimesulide is been available since 1985 and authorised in worldwide over 50 countries.

It has superior gastrointestinal safety as compared to other NSAIDs.

It is available in various forms apart from tablets such as in the form of Gell, powder, and suppositories. It’s also available in several trademarks.

Nimesulide brands such as Sulide, Nimalox, Nimesil, Nimulid, Nicip, Nimcap, Nise, Sulidene and Zolan.
Nimulid is also obtaining in the form of gel.

The Nimulid Transgel a brand from Nimesulide Transdermal Gel is indicated for post-traumatic inflammation, acute musculoskeletal disorders including sprains, strains, tendinitis, tenosynovitis, low back pain, periarthritis (shoulder pain) and osteoarthritis (joint pains), stiffness.

Nimesulide Medicine for Osteoarthritis

Nimesulide Medicine for Osteoarthritis

Nimesulide drug was launched in Italy for the first time as Aulin and Mesulid in 1985 and is presently available in more than 50 countries worldwide with different trademarks.

Nimesulide is used for the treatment of post-traumatic inflammation, acute musculoskeletal disorders including sprains, strains, tendinitis, tenosynovitis, low back pain, periarthritis (shoulder pain) and osteoarthritis (joint pains), stiffness.

Nimesulide brands such as Sulide, Nimalox, Nimesil, Nimulid, Nicip, Nimcap, Nise, Sulidene and Zolan

It has superior gastrointestinal safety as compared to other NSAIDs.

It is an analgesic and antipyretic in action. Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.

The maximum duration and dose of a treatment course with Nimesulide medicine is 15 days, 100 mg twice a day, to minimize the risk of hepatotoxicity.

Nimesulide Drug Solubility

Nimesulide Drug Solubility

Nimesulide is a unique non- steroidal anti-inflammatory drug that acts specifically on cyclo-oxygenase-2 and does not affect cyclo-oxygenase-1. Hence, it exerts its anti-inflammatory action characteristics of non- steroidal anti-inflammatory drug. Solubility of Nimesulide Increased on solubilization of drug in semi-polar solvents and non-ionic surfactants.

Solubility of Nimesulide was studied using different cosolvent mixtures and various classes of non-ionic surfactant. Solubility increased drastically (>70 mg/rnl) when polyethylene glycol 300 and polyethylene glycol 400 were used as solvents.

The quick dissolving tablets of Nimesulide contains super that accelerates the disintegration of tablets by virtue of their ability to soak up great deal of water once exposed to binary compound surroundings.

Nimesulide is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, Nimesulide should first be dissolved in ethanol and then diluted with the aqueous buffer of choice. Nimesulide has a solubility of approximately <200 μg/ml in a 10% DMSO in PBS (pH 7.2) solution using this method.

Nimesulide Medicine

Nimesulide Medicine

Nimesulide 100mg Therapeutic indications:

• Treatment of acute pain
• Symptomatic treatment of painful osteoarthritis
• Primary dysmenorrhoea.

Nimesulide Medicine uses:

• Nimesulide has less gastrointestinal adverse effects than other NSAIDs
• It has superior benefit-risk ratio to other drugs with a comparable safety and tolerability to placebo.
• Its multifactorial mode of action gives it a unique and broad action on inflammatory.
• Nimesulide is also safe in sensitive asthmatic patients. It is reported to be beneficial in relieving the symptoms of rhinitis, rhinopharyngitis tubaritis and seceretory otitis media with concomitant antibiotic treatment.
• Nimesulide has potent analgesic, anti-inflammatory and antipyretic activities

Nimesulide medicines are recommended for short duration of 15days

Nimesulide Tablets for Treatement of Headache

Nimesulide Tablets for Treatement of Headache

Postoperative headache may be caused by hypoglycemia and/or dehydration due to prolonged fasting, caffeine withdrawal, anxiety, and can be associated with preexisting migraine or headache.

NSAIDs- Nimesulide, is the first line pharmacological approaches to postoperative headache.

Nimesulide gives rapid onset of pharmacological action, good pain relief and stable effect for many hours is an ideal drug for postoperative headache with no contraindications.

It is also used for the treatment of acute musculoskeletal disorders including tendonitis, tenosynovitis, sprains, strains and low back pain, ear, nose and throat disorders, acute pain, osteoarthritis, primarydysmenorrhoea.

Dosage & When it is to be taken : 

The usual dose is 100mg twice a day.

Children: 5mg/kg of body weight in 2 or 3 divided doses.

Nimesulide Tablets use

Nimesulide Tablets Use

Nimesuilde is a pain killer NSAIDs drug best prescribed drug for treatment of acute pain, Primary dysmennorhea and also to treat degenerative joint disease.

Nimesulide is indicated in the treatment of a variety of painful inflammatory conditions including those associated with Osteoarthritis, Postoperative trauma, Sports injuries, Ear, Nose and Throat disorders, Dental surgery, Bursitis/Tendinitis, Thrombhophlebitis, Pharyngitis and Gynaecological disorders.

Nimesulide is a prescription drug with important analgesic properties. Therefore it is always recommended to use this medicine under a licensed physician supervision and as per approved indications.

Nimesulide Tablet is also used for:

• Rapid onset of action within 15 minutes
• Nimesulide has less gastrointestinal adverse effects than other NSAIDs.

Nimesulide Tablet For Treatment Of Headache

NIMESULIDE TABLET FOR TREATMENT OF HEADACHE

Postoperative headache may be caused by hypoglycemia and/or dehydration due to prolonged fasting, caffeine withdrawal, anxiety, and can be associated with preexisting migraine or headache.

NSAIDs- Nimesulide, is the first line pharmacological approaches to postoperative headache.

Nimesulide gives rapid onset of pharmacological action, good pain relief and stable effect for many hours is an ideal drug for postoperative headache with no contraindications.

It is also used for the treatment of acute musculoskeletal disorders including tendonitis, tenosynovitis, sprains, strains and low back pain, ear, nose and throat disorders, acute pain, osteoarthritis, primarydysmenorrhoea.

Nimesulide is available in various forms including tablets, suppositories, water-soluble powders, and topical gels.

The maximum duration of a treatment course with Nimesulide is 15 days.

Nimesulide 100mg Tablets/granules should be used for the shortest possible duration, as required by the clinical situation.

Nimesulide Efficacy

The efficacy of nimesulide (100mg twice daily) was compared with that of naproxen (500mg twice daily) in 53 adult patients with nonbacterial acute inflammation of the ear, nose or throat in a double-blind phase III clinical investigation. Both drugs were administered orally after meals for a mean duration of 8.7 days.

In this setting, nimesulide was associated with relief of pain and inflammatory signs (exudation and swelling). Indeed, treatment with nimesulide led to clinical improvement superior to that obtained with naproxen in terms of both rapidity of action and improvement of the symptoms at the end of therapy. Nimesulide therapy was also very well tolerated and no patient reported an adverse event. In contrast, 2 naproxen-treated patients reported episodic gastralgia of moderate intensity.

Nimesulide's therapeutic value in effectively and rapidly controlling inflammation and pain is supported by significant clinical evidence.

Clinical studies have been carried out in a wide variety of acute inflammatory and painful conditions with the aim of evaluating the analgesic activity of nimesulide in comparison to placebo and to some of the most common NSAIDs.

In these studies, the efficacy of nimesulide was consistently superior to placebo and at least comparable, or in some cases superior, to that observed for the reference drugs, with a particularly fast onset of the analgesic action.

Nimesulide posses analgesic properties with multifactorial mode of action for the treatment of musculoskeletal system, dysmenorrhoea, and acute pain.
The abilities of NSAID’s drug nimesulide to inhibit COX-2 preferentially and to exert other novel anti-inflammatory actions are consistent with good efficacy and safety with highly effective in reducing pain, inflammation and also helps in better penetration of the antibiotics.

It also undergoes extensive biotransformation. The recent study on the basis of analgesic activity of Nimesulide has proved that it has a quicker onset which shows relief from pain relief and inflammation within 15 minutes from drug intake.

Nimesulide is recommended for the shortest duration necessary to control symptoms in patients with acute pain or primary dysmenorrhoea.

Nimesulide Tablets for Headache

Nimesulide Tablets for Treatement of Headache

Postoperative headache may be caused by hypoglycemia and/or dehydration due to prolonged fasting, caffeine withdrawal, anxiety, and can be associated with preexisting migraine or headache.

NSAIDs- Nimesulide, is the first line pharmacological approaches to postoperative headache.

Nimesulide gives rapid onset of pharmacological action, good pain relief and stable effect for many hours is an ideal drug for postoperative headache with no contraindications.

It is also used for the treatment of acute musculoskeletal disorders including tendonitis, tenosynovitis, sprains, strains and low back pain, ear, nose and throat disorders, acute pain, osteoarthritis, primarydysmenorrhoea.

Dosage & When it is to be taken : 

The usual dose is 100mg twice a day.

Children: 5mg/kg of body weight in 2 or 3 divided doses.

Nimesulide Gel

Nimesulide Gel

Nimesulide is available in various forms including tablets, suppositories, water-soluble powders, and topical gels.

Nimesulide Gel (Nimesulide/Methyl Salicylate/Menthol/Capsaicin) is used to treat chronic and acute musculoskeletal disorders such as soft tissue injuries or non-articular rheumatic disorders, including discomfort in the muscles, tendonitis, back pain/ache, arthritis, tenosynovitis sprains, or strains.

Nimesulide is used topically as an analgesic with NSAID benefits and functions by inhibiting particular nerve impulses sent from the periphery to your central system, leading to a decrease of sensitivity from the kinds of symptoms.

Dosage and Administration

Nimesulide Gel is apply to the affected area, rubbing in a thin layer of the gel 2 to 4 times every day. For best results, wash the application area beforehand to clean away any oil, grease, or bacteria, allowing the gel to absorb more easily.

Nimesulide is available in assortment of structures like as tablets and syrup for oral organization and gels for topical application.

The anti-inflammatory activity of topically applied Nimesulide gel demonstrations particularly on cyclo-oxygenase-2 which applies less gastrointestinal antagonistic impacts than different NSAIDs.

Nimesulide tablet for joint pain relief

Nimesulide Medicine for Joint pain treatment

Joint ache influenced by osteoarthritis (OA) which is a gathering of mechanical abnormailities including debasement of joints, and NSAID’s – Nimesulide is most regularly used to treat agony connected with OA.

The primary symptom is agony, creating loss of capacity and regularly solidness. Osteoarthritis (OA) is brought about by aging joints, damage, and obesity. OA usually influences the hands, feet, spine, and the expansive weight bearing joints, for example, the hips and knees.


Nimesulide proved to be significantly more viable in giving symptomatic relief. Nimesulide speaks to a successful operator for the treatment of joint ache, with specific reference to the quick onset of its pain relieving impact.

It additionally utilized for the treatment of primary Dysmenorrhea, and Acute ache.

Nimesulide shows significant diminishments in pain and irritation observed in 15 minutes with pain relieving and antipyretic properties.

Nimesulide Tablet Dosage

The main purpose of Nimesulide tablets is for the treatment of painful inflammatory conditions, back pain, dysmenorrhea, postoperative pain, osteoarthritis, and fever.

The usual dose is 100mg twice a day.
Children: 5mg/kg of body weight in 2 or 3 divided doses.

The minimum effective dose should be used for the shortest duration to reduce the undesirable effects.

The maximum duration of a treatment course with Nimesulide is 15 days.

Nimesulide 100mg Tablets/granules should be used for the shortest possible duration, as required by the clinical situation.

Adults:
100mg bid after meal.

Elderly:
In elderly patients there is no need to reduce the daily dosage

Children (< 12 years):
Nimesulide 100mg Tablets/granules is contraindicated in these patients.

Adolescents (from 12 to 18 years):
on the basis of the kinetic profile in adults and on the pharmacodynamic characteristics of nimesulide, no dosage adjustment in these patients is necessary.

Oral dosage form prescribed for the shortest duration

In adults:100 mg In children: 5 mg/kg/day in 2 or 3 divided doses.

Nimesulide has superior gastrointestinal safety as compared to other NSAIDs. Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.

Nimesulide tablet prevents cancer by inhibiting the proliferation of various types of cancer cells mainly via COX-2 independent mechanisms. It is also used for dry skin, to improve skin-tone,and to increase energy.

Nimesulide treatment also brought about an immediate and significant improvement in over-all pain, exudation, oedema and headache.

Nimesulide multifactorial approach

Nimesulide was launched in Italy for the first time as Aulin and Mesulid in 1985 and is presently available in more than 50 countries worldwide in different trademarks.

Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.It is available in the market in various like tablets (100 mg), granules for oral suspension (100 mg), suppositories (200 mg) and gel (3%).

The Gel needed to be applied is three to four times per day depending on the dimension of the affected size and response. Medicalcare ought to be reviewed after 4 weeks.

Trademarks of Nimesulide include of Sulide, Nimalox, Nimesil, Nimulid, Nicip, Nimcap, Nise, Sulidene and Zolan e.t.c.Nimulid Transgel is indicated for post-traumatic inflammation, acute musculoskeletal disorders including sprains, strains, tendinitis, tenosynovitis, low back pain, periarthritis (shoulder pain) and osteoarthritis (joint pains), stiffness.

Nimesulide has superior gastrointestinal safety as compared to other NSAIDs with multi factorial approach for treating post-traumatic inflammation, acute musculoskeletal disorders including sprains, strains, tendinitis, tenosynovitis, low back pain, periarthritis (shoulder pain) and osteoarthritis (joint pains), stiffness.

Nimesulide for the treatment of degenerative joint disease

The most prescribed NSAID drug Nimesulide is used for the treatment of Painful degenerative arthritis (Swelling within the joints).

Nimesulide is also gives the best treatment in acute pain and Primary dysmennorhea. Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.

Nimesulide drug must be prescribed by a physician and doctor and is usually recommended for the age higher than 12 years.

Nimesulide is a prescription-only drug and must be prescribed by a licensed physician after careful evaluation of the patient’s characteristics and needs.

Additionally it helps in increasing energy, improve skin tone, and to cure Heart diseases, and also helpful for dry skin and is usually recommended for the shortest period necessary to control symptoms in patients with pain.

Nimesulide is also offered in the form of gell, powder which is now available in worldwide of more than 50 countries. It is also available in different trademarks like Nimesil, Nimulid, Nise e.t.c.

Nimesulide and its antipyretic properties

 non-steroidal anti-inflammatory drug (NSAID) – Nimesulide is a relatively COX-2 selective,with analgesic and antipyretic properties. 

NImesulide shows multifactorial mode of action for the treatment of for post-traumatic inflammation, acute musculoskeletal disorders including sprains, strains, tendinitis, tenosynovitis, low back pain, periarthritis (shoulder pain) and osteoarthritis (joint pains), stiffness.

The drug is developed by Helsinn Healthcare. Medicines containing Nimesulide are on the market since 1985 and are authorised in a number of Member States.

Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.

Nimesulide is available in the form of tablets (100 mg), granules for oral suspension (100 mg), suppositories (200 mg) and gel (3%).

The maximum duration and dose of a treatment course with Nimesulide is 15 days, 100 mg twice a day, to minimize the risk of hepatotoxicity.

Nimesulide Tablet for Osteoarthritis

Osteoarthritis (OA) is caused by aging joints, injury, and obesity. OA symptoms include joint pain and stiffness.

Nimesulide is used for the treatment of post-traumatic inflammation, acute musculoskeletal disorders including sprains, strains, tendinitis, tenosynovitis, low back pain, periarthritis (shoulder pain) and osteoarthritis (joint pains), stiffness.

Nimesulide drugs also reduce inflammation. Inflammation is the body's response to irritation or injury and is characterized by redness, warmth, swelling, and pain. 

Nimesulide drug was launched in Italy for the first time as Aulin and Mesulid in 1985 and is presently available in more than 50 countries worldwide with different trademarks.

It is an analgesic and antipyretic in action. Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.

The maximum duration and dose of a treatment course with Nimesulide medicine is 15 days, 100 mg twice a day, to minimize the risk of hepatotoxicity.

Non-steroidal anti-inflammatory drug – Nimesulide

The anti-inflammatory drug mechanism of Nimesulide should only be prescribed as second line treatment. The decision to prescribe nimesulide should be based on assessment of the individual patient’s overall risks.

Main purpose of using this drug is to treat acute pain, to treat degenerative joint disease, to treat primary dysmenorrhoea in adolescents and adults above 12 years old, it is used for treatment of all types of pains resulting from sports injury, depression etc.

Additionally it helps in increasing energy, improve skin tone, and to cure Heart diseases, and also helpful for dry skin and is usually recommended for the shortest period necessary to control symptoms in patients with pain

Nimesulide has superior gastrointestinal safety as compared to other NSAIDs.
Its multifactorial mode of action gives a unique and broad action on inflammatory processes.

Nimesulide is also offered in the form of gell, powder which is now available in worldwide of more than 50 countries. It also available in different trademarks like Nimesil, Nimulid, Nise e.t.c

Nimesulide Tablet Chemical Formula

Nimesulide Tablet Chemical Formula

Nimesulide, a wide prescribed medication analgesic drug belongs to BCS category II and exhibit low and variable oral bioavailability.

Nimesulide (4-nitro-2-phenoxymethanesulfoanilide) may be a selective Cox-2 anti-inflammatory drug drug. This compound, a by-product of p-nitrophenyl methane series sulfa, is structurally a singular non-steroidal anti-inflammatorydrug. It belongs to selective COX-2inhibitors, with a potent analgesic activity.

it’s indicated as second line treatment for acute pain, symptomatic treatment of painful degenerative joint disease and first dysmenorrhoea.

It’s conjointly used for the treatment of skin-tone, Heart diseases and dry skin.

Features include :

• Fascinating results
• Useful and helpful
• No facet effects
• Quick and fast effects

Usage of Nimesulide 100mg- pill :

• Analgesic and antipyretic.
• Rheumatic inflammatory disease, degenerative joint disease, alternative chronic joint disorders treatment
• Musculo skeletal disorders treatment
• Thrombophlebitis.
• Improves skintone
• Heart Diseases
• Dry Skin
• Cancer treatment

Nimesulide tablet chemical formula

Nimesulide, a wide prescribed medication analgesic drug belongs to BCS category II and exhibit low and variable oral bioavailability.

Nimesulide (4-nitro-2-phenoxymethanesulfoanilide) may be a selective Cox-2 anti-inflammatory drug drug. This compound, a by-product of p-nitrophenyl methane series sulfa, is structurally a singular non-steroidal anti-inflammatorydrug. It belongs to selective COX-2inhibitors, with a potent analgesic activity.

it’s indicated as second line treatment for acute pain, symptomatic treatment of painful degenerative joint disease and first dysmenorrhoea.

It’s conjointly used for the treatment of skin-tone, Heart diseases and dry skin.

Features include :

• Fascinating results
• Useful and helpful
• No facet effects
• Quick and fast effects

Usage of Nimesulide 100mg- pill :

• Analgesic and antipyretic.
• Rheumatic inflammatory disease, degenerative joint disease, alternative chronic joint disorders treatment
• Musculo skeletal disorders treatment
• Thrombophlebitis.
• Improves skintone
• Heart Diseases
• Dry Skin
• Cancer treatment

Nimesulide formulation

Nimesulide, a wide endorsed medicine pain relieving drug fits in with BCS classification II and show low and variable oral bioavailability. 

Nimesulide (4-nitro-2-phenoxymethanesulfoanilide) may be a particular Cox-2 anti-inflammatory medication. This compund, a by-result of p-nitrophenyl methane arrangement sulfa, is structurally a solitary non-steroidal anti-inflammatorydrug. It has a place with particular COX-2inhibitors, with an intense pain relieving movement.

its shown as second line treatment for  acute pain, symptomatic treatment of excruciating degenerative joint ailment and first dysmenorrhoea.

It's conjointly utilized for the treatment of skin-tone, Heart illnesses and dry skin.

Nimesulide tablet features incorporate :

• Fast results
• Helpful and supportive
• No feature impacts
• Fast and quick effects

Use of Nimesulide 100mg- pill :

• Pain relieving and antipyretic.
• Rheumatic inflammatory sickness, degenerative joint ailment, elective perpetual joint issue treatment
• Musculo skeletal issue treatment
• Thrombophlebitis.
• Enhances skintone
• Heart Diseases
• Dry Skin
• Malignancy treatment
• 
  

Efficacy of nimesulide in pain and inflammation

Nimesulide is a prescription non-steroidal anti-inflammatory drug with a multifactorial mode of action for the treatment of for post-traumatic inflammation, acute musculoskeletal disorders including sprains, strains, tendinitis, tenosynovitis, low back pain, periarthritis (shoulder pain) and osteoarthritis (joint pains), stiffness.

Its multifactorial mode of action gives it a unique and broad action on inflammatory processes. It undergoes extensive biotransformation.

Clinical studies have been carried out in a wide variety of acute inflammatory and painful conditions with the aim of evaluating the analgesic activity of nimesulide in comparison to placebo and to some of the most common NSAIDs.

In these studies, the efficacy of nimesulide was consistently superior to placebo with a particularly fast onset of the analgesic action.

This rapid onset of analgesic action shows meaningful reductions in pain and inflammation observed within 15 minutes from drug intake.

Nimesulide Forms

Nimesulide Forms and Its Uses

The best prescribed Nimesulide tablet is used for the treatment of acute pain, Primary dysmennorhea and also to treat degenerative joint disease.

Forms: A variety of Nimesulide forms are available in the market like in the form of tablets and syrup for oral administration and gels for topical application.

Dose: Nimesulide is available with the dosage of 100 mg for tablets, 100 mg for granules for oral suspension, 200mg for suppositories and 3% of gel.

Nimesulide tablets exerts less gastrointestinal adverse effects than other NSAIDs. It is available in different brands in worldwide among 50 countries.

Nimesulide is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF).

Nimesulide transdermal gel is a well tolerated novel hydroalcoholic microcarrier based drug delivery system with penetration enhancer, indicated for a variety of conditions characterized by pain, inflammation and stiffness, such as osteoarthritis, periarthritis, post-traumatic or acute musculoskeletal disorders including tendinitis, tenosynovitis, sprains, strains and low back pain.

Solubility of Nimesulide was studied using different cosolvent mixtures and various classes of non-ionic surfactant. Solubility increased drastically (>70 mg/rnl) when polyethylene glycol 300 and polyethylene glycol 400 were used as solvents.

The quick dissolving tablets of Nimesulide contains superdisintegrants, that accelerates the disintegration of tablets by virtue of their ability to soak up great deal of water once exposed to binary compound surroundings.

Nimesulide BP 100mg

Nimesulide BP 100mg

Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory pain killer drug(NSAID) prescribed for treatment of acute pain, Primary dysmennorhea and degenerative joint disease.

This medicine has potent analgesic, anti pyretic and anti-inflammatory activity on oral & rectal administration.

Nimesulide BP 100mg prevents the release of prostaglandins which is responsible for inflammation, pain & fever.

Nimesulide is a selective inhibitor of prostaglandin synthesis but appears to exert its therapeutic effect by a variety of other mechanisms like inhibition of platelet-activating factor (PAF), tumour necrosis factor-alpha (TNF alpha,) Proteinase & histamine etc.

Nimesulide is Indicated in reducing pain, fever and inflammatory symptoms of:

• Chronic arthritis
• Osteo arthritis
• Otorhinolary diseases
• Soft tissues and oral cavity inflammation
• Dysmenorrhoea
• Thrombosis
• Urogenital disease
• Postoperative pain states
• Sports injuries

Nimesulide Tablet Indications

imesulide Tablet Indication

Anti-inflammatory Analgesics tablet – Nimesulide is required for the quick treatment of severe muscular pains and inflammatory problems. Nimesulide tablets is available in different countries in the world.

Nimesulide is Indicated in reducing pain, fever and inflammatory symptoms of:

• Chronic arthritis
• Osteo arthritis
• Otorhinolary diseases
• Soft tissues and oral cavity inflammation
• Dysmenorrhoea
• Thrombosis
• Urogenital disease
• Postoperative pain states
• Sports injuries

Uses of Nimesulide:

• Rapid onset of action within 15 minutes
• Rapidly relieves pain in arthritis

Nimesulide Uses

Nimesulide Tablet Uses

Nimesulide medication is a non-steroidal anti-inflammatory drug with analgesic and antyperetic properties, prescribed for painful inflammatory conditions, back pain, dysmenorrhea and etc.

The usual dosage of Nimesulide is 100mg twice a day. For children it should be taken 5mg/kg of body weight in 2 or 3 divided doses

Nimesulide is used to reduce:

1. Osteoarthritis
2. Low back Pain
3. Sports injury
4. Dental pain
5. Moderate pain & fever
6. Dysmenorrhea

Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.

Nimesulide is reported to be beneficial in relieving the symptoms of rhinitis, rhinopharyngitis tubaritis and seceretory otitis media with concomitant antibiotic treatment.

Nimesulide Tablet Synthesis

Nimesulide, a COX-2 selective drug, possesses anti-inflammatory and analgesic properties. Moreover, it has low gastro-intestinal and renal toxicity.

Its main purpose is to treat acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea .

As for other NSAIDs the use of Nimesulide is preffered for the shortest duration necessary to control symptoms in patients with acute pain or primary dysmenorrhoea. The efficacy of Nimesulide was consistently superior to placebo with its particularly rapid onset action.

The maximum duration and dose of a treatment course with nimesulide is 15 days, 100 mg twice a day, to minimize the risk of hepatotoxicity.

Nimesulide Tablet shows the result from pain within 15min from the drug intake

Nimesulide is available in the from of tablet, capsule and gel with the dosage of 100mg.

Nimesulide Tablet Dose

Nimesulide Tablet Dose

Nimesulide medication is a non-steroidal anti-inflammatory drug, prescribed for painful inflammatory conditions, back pain, dysmenorrhea, postoperative pain, osteoarthritis, and fever.

Nimesulide Dosage:

Adults: 100 mg twice daily
Children: 5mg/kg of body weight in 2 or 3 divided doses.

The minimum effective dose should be used for the shortest duration to reduce the undesirable effects.

The maximum duration of a treatment course with Nimesulide is 15 days.

Nimesulide 100mg Tablets/granules should be used for the shortest possible duration, as required by the clinical situation.

Adults:
100mg bid after meal.

Elderly:
In elderly patients there is no need to reduce the daily dosageAdolescents (from 12 to 18 years):

on the basis of the kinetic profile in adults and on the pharmacodynamic characteristics of nimesulide, no dosage adjustment in these patients is necessary.

Oral
Dysmenorrhoea
Adult: 100 mg bid.

Oral
Osteoarthritis
Adult: 100 mg bid

Oral
Postoperative pain
Adult: 100 mg bid. 

Oral
Acute pain
Adult: 100 mg bid.

Rectal
Acute pain
Adult: 200 mg bid

Rectal
Osteoarthritis
Adult: 200 mg bid

Rectal
Primary dysmenorrhoea
Adult: 200 mg bid

Nimesulide Structure

Nimesulide Structure

Nimesulide is generally utilized as a part of the treatment of inflammatory torment which hinders the protein cyclooxygenase-2 (COX-2) and has better gastro-intestinal mediocrity in addition to different NSAIDs in its class.

Nimesulide (4-nitro-2-phenoxymethanesulfoanilide) This compound, a by-product of p-nitrophenyl methane series sulfa, is structurally a singular non-steroidal anti-inflammatory drug.

It is available in more than 50 countries worldwide.

Features:

• Amongst most effective yet gastro friendly
• Non steroidal anti inflammatory drug (NSAID)
• Nimesulide targets COX-2 an enzyme responsible for inflammation & pain.
• Uses of Nimesulide:
  1. Nimesulide tablet has excellent gastrointestinal safety in comparison to other medication.
  2. Rapid onset of action within 15 minutes
  3. Rapidly relieves pain in arthritis

Nimesulide Solubility

Nimesulide Solubility

Nimesulide is a unique non- steroidal anti-inflammatory drug that acts specifically on cyclo-oxygenase-2 and does not affect cyclo-oxygenase-1. Hence, it exerts its anti-inflammatory action characteristics of non- steroidal anti-inflammatory drug. Solubility of Nimesulide Increased on solubilization of drug in semi-polar solvents and non-ionic surfactants.

Solubility of Nimesulide was studied using different cosolvent mixtures and various classes of non-ionic surfactant. Solubility increased drastically (>70 mg/rnl) when polyethylene glycol 300 and polyethylene glycol 400 were used as solvents.

The quick dissolving tablets of Nimesulide contains superdisintegrants, that accelerates the disintegration of tablets by virtue of their ability to soak up great deal of water once exposed to binary compound surroundings.

Nimesulide is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, Nimesulide should first be dissolved in ethanol and then diluted with the aqueous buffer of choice. Nimesulide has a solubility of approximately <200 μg/ml in a 10% DMSO in PBS (pH 7.2) solution using this method.

Nimesulide Tablets Use

Nimesulide Tablets Use

Nimesulide is a popular NSAID prescribed for painful inflammatory conditions, back pain, dysmenorrhea associated with musculoskeletal system, Thrombophlebitis, dental pain and in ENT inflammation. 

Nimesulide is a prescription drug with important analgesic properties. Therefore it is always recommended to use this medicine under a licensed physician supervision and as per approved indications.

Nimesulide is available in various forms including tablets, suppositories, water-soluble powders, and topical gels. It is an analgesic and antipyretic in action.

Nimesulide Drug uses: 

• Nimesulide has less gastrointestinal adverse effects than other NSAIDs.
• It has superior benefit-risk ratio to other drugs with a comparable safety and tolerability to placebo.
• Rapid onset of action within 15 minutes
• Rapidly relieves pain in arthritis
• Its multifactorial mode of action gives it a unique and broad action on inflammatory.
• Nimesulide is also safe in sensitive asthmatic patients.
• It is reported to be beneficial in relieving the symptoms of rhinitis, rhinopharyngitis tubaritis and seceretory otitis media with concomitant antibiotic treatment.
• Nimesulide has potent analgesic, anti-inflammatory and antipyretic activities.

Nimesulide Brands in India

Nimesulide Brands in India

NSAID’s tablet Nimesulide is a widely prescribed anti-inflammatory analgesic drug belongs to BCS class II which is required for the quick treatment of severe muscular pains and inflammatory problems.

NSAID’s tablet Nimesulide is been available since 1985 and sanction with assorted trade names in worldwide in abundance of 50 countries.

Nimesulide is distributed world-wide through a network of selected international partners. 

Different trademarks of Nimesulide are: For Oral Use: Sulide, Nimalox, Nimesil, Nimulid, Nicip (India),, Nimcap, Nise, Sulidene and Zolan, Pain Lock(VIP Pharma India ), Nilden (Mexico),

Why Nimesulide Drugs are Used?

The main purpose of using Nimesulide are:

• To treat acute pain
• To treat osteoarthritis
• To treat primary dysmenorrhoea in adolescents and adults above 12 years old.

Nimesulide tablet incorporates:

• Fast results
• Helpful and supportive
• No feature impacts
• Fast and quick effects

Nimesulide Synthesis

Nimesulide Drug Synthesis

Nimesulide is a non-steroidal anti-inflammatory agent that is generally utilized as a part of the treatment of inflammatory torment which hinders the protein cyclooxygenase-2 (COX-2) and has better gastro-intestinal mediocrity in addition to different NSAIDs in its class.

Its approved signs are the treatment of intense torment, the symptomatic treatment of osteoarthritis and essential dysmenorrhoea, sports wounds and so on.

A variety of new Nimesulide derivatives were synthesized through incorporation of a 5-LOX pharmacophore into nimesulide followed with some structural modifications, which were then characterized for dual enzyme inhibitors for these two types of enzymes (Cyclooxygenase-½ (COX-½) and 5-lipoxygenase (5-LOX) ). Their structure-activity relationships (SARs) were studied, and compound 20f was found to be an excellent dual enzyme inhibitor.

Its binding conformation and interaction mode were studied with molecular docking experiments. Compound 20f could become a lead compound for further development for potential anti-inflammatory drugs.

Clinically it has demonstrated that it supports an especially good profile as far as gastrointestinal tolerability.