Nimesulide Medicine

The European Medicines Agency has completed a review of the safety and effectiveness of medicines containing Nimesulide (capsules, tablets, suppositories and powder or granules for oral suspension).

It has concluded that Nimesulide has great benefits for the treatment of acute pain and primary dysmenorrhoea. It issued a recommendation that it should be used for the shortest duration (<15days).

It is also used for dry skin and to improve skin tone. Usage of Nimesulide 100mg- Tablet.

• Nimesulide has less gastrointestinal adverse effects than other NSAIDs
• It has superior benefit-risk ratio to other drugs with a comparable safety and tolerability to placebo.
• Its multifactorial mode of action gives it a unique and broad action on inflammatory.
• Nimesulide is also safe in sensitive asthmatic patients. It is reported to be beneficial in relieving the symptoms of rhinitis, rhinopharyngitis tubaritis and seceretory otitis media with concomitant antibiotic treatment.
• Nimesulide has potent analgesic, anti-inflammatory and antipyretic activities

Nimesulide tablet has great analgesic and antipyretic properties which is nothing but relief from pain and reduction of body temperature. Nimesulide medicines are recommended for short duration of 15days

Nimesulide Drug Advantages

Nimesulide is a non-steroidal anti inflammatory drug prescribed for the treatment of acute pain, joint pain and primary dysmenorrhoea.

Advantages for the treatment of Nimesulide:

• Nimesulide has less gastrointestinal adverse effects than other NSAIDs.
• It has superior benefit-risk ratio to other drugs with a comparable safety and tolerability to placebo. 
• Its multifactorial mode of action gives it a unique and broad action on inflammatory. 
• Nimesulide is also safe in sensitive asthmatic patients. 
• It is reported to be beneficial in relieving the symptoms of rhinitis, rhinopharyngitis tubaritis and seceretory otitis media with concomitant antibiotic treatment.
• Nimesulide has potent analgesic, anti-inflammatory and antipyretic activities.

Dose: 

Nimesulide is available with the dosage of 100mg its measurements ought to be taken by medicine of doctor and specialist which will help to take proper dosage for good come about. Nimesulide is recommended to be used for the shortest duration

Comparision of Nimesulide and Paracetamol Tablets

Pharmacodynamic Nimesulide – is an inhibitor of cyclooxygenase so it inhibits synthesis of destructive prostaglandins and spares cytoprotective prostaglandins. Nimesulide appears to exert its effects also through a variety of other mechanisms and involves interference with the production action of mediators other than prostaglandins such as enzymes, toxic oxygen derivatives, cytokines, platelet activating factor and histamine.

Paracetamol – is a valuable central analgesic but weak peripheral anti-inflammatory agent and exhibits agent and exhibits antipyretic action.

Pharmacokinetic Nimesulide – after oral administration the peak plasma concentrations of 1.98-9.85 mg/L are achieved within 1 to 2hrs.

Paracetamol – is rapidly and completely absorbed from gastrointestinal tract. Peak plasma is achieved within 2 to 3hrs

Nimesulide suspension (1.5 mg/kg three times daily) or paracetamol syrup (10 mg/kg four times daily) were administered orally till fever resolved. blood heat was recorded and native pain and general discomfort assessed.

According to the result, Nimesulide was as effective as paracetamol in reducing fever, local pain, and general discomfort. Nimesulide therefore appears to be a minimum of as effective as paracetamol in terms of antipyretic and anti inflammatory activity in children with inflammation of the upper tract and fever.
The other recent study with the patients aged between twelve and sixty years on the premise of analgesic effectiveness and tolerability has well-tried that the analgesic results of Nimesulide had a faster onset (<15 minutes) and was stronger (based on patient opinion). And were well tolerated.

Indications: Sprains, wounds, injury Post surgical plan Dental pain Arthritic Pain pain, fever inflammation accompanying respiratorty track infection and ENT conditions

Uses of Nimesulide Gel

Nimesulide is a unique non- steroidal anti-inflammatory drug that acts specifically on cyclo-oxygenase-2 which exerts less gastrointestinal adverse effects than other NSAIDs, and is mostly prescribed for the treatment of acute pain, joint pain and primary dysmenorrhoea.

Nimesulide is available in variety of forms like in the form of tablets and syrup for oral administration and gels for topical application.

Nimesulide transdermal gel is a well endured novel hydroalcoholic microcarrier based drug delivery system with penetration enhancer.

Indications:
Nimesulide gel is indicated for a variety of conditions portrayed by agony, aggravation and solidness, for example, osteoarthritis, periarthritis, post-traumatic or intense musculoskeletal issue including tendinitis, tenosynovitis, sprains, strains and low back torment. It Functions by restraining specific nerve motivations sent from the outskirts to your focal framework.

Nimesulide Tablet Formulation

Nimesulide, a widely prescribed anti-inflammatory analgesic drug belongs to BCS class II and exhibit low and variable oral bioavailability.

 

Nimesulide (4-nitro-2-phenoxymethanesulfoanilide) may be a particular Cox-2 anti-inflammatory medication. This compund, a by-result of p-nitrophenyl methane arrangement sulfa, is structurally a solitary non-steroidal anti-inflammatorydrug. It has a place with particular COX-2inhibitors, with an intense pain relieving movement.

its shown as second line treatment for  acute pain, symptomatic treatment of excruciating degenerative joint ailment and first dysmenorrhoea.

Nimesulide tablet incorporates:

• Fast results
• Helpful and supportive
• No feature impacts
• Fast and quick effects

Nimesulide Tablet Advantages:

• Nimesulide has less gastrointestinal adverse effects than other NSAIDs
• It has superior benefit-risk ratio to other drugs with a comparable safety and tolerability to placebo.
• Its multifactorial mode of action gives it a unique and broad action on inflammatory.
• Nimesulide is also safe in sensitive asthmatic patients. It is reported to be beneficial in relieving the symptoms of rhinitis, rhinopharyngitis tubaritis and seceretory otitis media with concomitant antibiotic treatment. 
• Nimesulide has potent analgesic, anti-inflammatory and antipyretic activities

Nimesulide Painkiller tablet

A unique Non-steroidal anti inflammatory drug Nimesulide was developed by Helsinn Healthcare and is marketed world-wide around 50 countries. It has proven benefits in the treatment of Acute (short term) pain, Painful osteoarthritis (Swelling in the joints) and Primary dysmennorhea ( Period Pains).

Nimesulide is a prescription anti-inflammatory drug with significant analgesic properties and antipyretic properties. It has superior gastrointestinal safety as compared to other NSAIDs.

Indications:

• Pain relief
• Rheumatoid arthritis
• Osteoarthritis
• Low back pain
• Post operative pain management
• Gynecological surgery: Hysterectomy,
• Dental pain

Nimesulide drug must be prescribed by a physician and doctor and is usually recommended for the age higher than 12 years.

Nimesulide is available with distinctive brands like Sulide, Nimalox, Nimesil, Nimulid, Nicip, Nimcap, Nise, Sulidene and Zolan.

Solubiltiy of Nimesulide in various solvents

Nimesulide is a unique non- steroidal anti-inflammatory drug which is most commonly prescribed for the treatment of various inflammatory conditions such as tonsillitis, pharyngitis, stomatitis, rheumatoid arthritis, osteoarthritis, low back pain.

A variety of Nimesulide forms are available in the market like in the form of tablets and syrup for oral administration and gels for topical application.

Solubility of Nimesulide in various solvents and solvent-co-solvent mixtures was determined in relation to the development of parenteral formulations.

Nimesulide is soluble in organic solvents like alcohol, DMSO, and dimethyl formamide (DMF).

The quick dissolving tablets of Nimesulide contains superdisintegrants, that accelerates the disintegration of tablets by virtue of their ability to soak up great deal of water once exposed to binary compound surroundings.

Nimesulide Tablet Advantages

Nimesulide is a non-steroidal anti inflammatory drug prescribed for the treatment of acute pain, joint pain and primary dysmenorrhoea.

Advantages for the treatment of Nimesulide:

• Nimesulide has less gastrointestinal adverse effects than other NSAIDs
• It has superior benefit-risk ratio to other drugs with a comparable safety and tolerability to placebo.
• Its multifactorial mode of action gives it a unique and broad action on inflammatory.
• Nimesulide is also safe in sensitive asthmatic patients. It is reported to be beneficial in relieving the symptoms of rhinitis, rhinopharyngitis tubaritis and seceretory otitis media with concomitant antibiotic treatment. 
• Nimesulide has potent analgesic, anti-inflammatory and antipyretic activities

Dose:

• Nimesulide is available with the dosage of 100mg its measurements ought to be taken by medicine of doctor and specialist which will help to take proper dosage for good come about.
• Nimesulide is recommended to be used for the shortest duration

Nimesulide Tablet Brands

NSAID’s tablet Nimesulide is been available since 1985 and sanction with assorted trade names in worldwide in abundance of 50 countries.

Main purpose of using Nimesulide drug is to:

• Treat exceptional torment from degenerative joint disease.
• Treat crucial dysmenorrhoea in youngsters and  adults in excess of 12 years old.
• Treat various sorts of torments coming to fruition as a result of recreations harm, dejection and so forth.
• Treat Cancer
• Treat dry skin

Nimesulide is available in distinctive brands, for instance, Sulide, Nimalox, Nimesil, Nimulid, Nicip, Nimcap, Nise, Sulidene and Zolan.

Nimulid is used for post-traumatic irritation, extreme musculoskeletal issue including sprains, strains, tendinitis, tenosynovitis, low spinal pain, periarthritis (shoulder anguish) and osteoarthritis (joint torments), immovability.

Nise (100 mg) – Tablet, contains Generic Medicine Nimesulide- 100 mg. which is a non-steroidal alleviating drug

Nimesulide Gel for pain relief

Nimesulide transdermal gel is a well endured novel hydroalcoholic microcarrier based drug delivery system with penetration enhancer. This is reason for predominant adequacy of Nimesulide Transdermal Gel and it is connected principally for topical agony administration.

Nimesulide is a non-steroidal mitigating( (NSAID) operators which have pain relieving properties. The product has been formed utilizing a novel mix of solvents for solubilization of Nimesulide.

Nimesulide gel is indicated for a variety of conditions portrayed by agony, aggravation and solidness, for example, osteoarthritis, periarthritis, post-traumatic or intense musculoskeletal issue including tendinitis, tenosynovitis, sprains, strains and low back torment. It Functions by restraining specific nerve motivations sent from the outskirts to your focal framework.

Nimesulide displayed better efficacy it likewise exhibited speedier onset of activity. Significant concentration of Nimesulide could be detected in the blood within 30 minutes of treatment and persisted for 8 hours post treatment

Nimesulide Tablet Solubility

Nimesulide NSAID’s tablet is an efficient and safe therapeutic selection for the treatment of assorted painful inflammatory conditions like inflammation, sore throat, stomatitis, arthritis, degenerative joint disease, low back pain etc., with a speedy onset of analgesic activity.

The quick dissolving tablets of Nimesulide contains superdisintegrants, that accelerates the disintegration of tablets by virtue of their ability to soak up great deal of water once exposed to binary compound surroundings.

Nimesulide is soluble in organic solvents like alcohol, DMSO, and dimethyl formamide (DMF).

Nimesulide is out there in varied forms like Nimesulide Tablets, Nimesulide Powder/granules, Nimesulide Gel, suppositories.

Clinical proved that it is available to support a particularly good profile in terms of gastrointestinal tolerability.

The employment of Nimesulide is usually recommended for the shortest length necessary to regulate symptoms in patients with acute pain or primary dysmenorrhoea.

Nimesulide Tablet for cancer treatment

Cancer, also known as a malignant tumour or malignant neoplasm, which is caused due to a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. Cyclooxygenase-2 (COX-2) inhibitor.

Nimesulide inhibits the proliferation of various types of cancer cells mainly via COX-2 independent mechanisms, which makes it a good lead compound for anti-cancer drug development.

There are more than 100 types of cancer, including breast cancer, skin cancer, lung cancer, colon cancer, prostate cancer, and lymphoma. Symptoms vary depending on the type.

A series of new Nimesulide analogs were synthesized based on the structure–function analysis generated previously. It displayed very potent anti-cancer activity.

Significantly suppresses the growth of multiple cancer. By usng Nimesulide the sizes of the colon carcinomas were also decreased.

Pharmacokinetic studies demonstrate the good bioavailability of the compound. A set of non-COX-2 active Nimesulide anti-cancer derivatives were synthesized. It works as a good lead compound for anti-cancer drug development

Drug bank of Nimesulide medicine

Non-steroidal drug Nimesulide endorsed evidences are the treatment of intense agony, the symptomatic treatment of osteoarthritis and essential dysmenorrhoea, sports wounds and so on.

It has special properties of pain relieving and antipyretic which, specially inhibits the chemical cyclooxygenase-2 (COX-2) and has better gastro-intestinal tolerability.

It is utilized for treatment of different sorts of agonies coming about because of games harm, despondency and so on.

Dose:
Nimesulide is available with the dosage of 100mg its measurements ought to be taken by medicine of doctor and specialist which will help to take proper dosage for good come about.

Pharmacology:
Sustenance, sexual orientation and progressed age have insignificant impacts on nimesulide pharmacokinetics.

Uses:

• Analgesic and antipyretic.
• Rheumatoid arthritis, osteoarthritis, other degenerative joint disorders.
• Musculo skeletal disorders.
• Thrombophlebitis.