Wednesday, November 19, 2014

Solubiltiy of Nimesulide in various solvents

Nimesulide is a unique non- steroidal anti-inflammatory drug which is most commonly prescribed for the treatment of various inflammatory conditions such as tonsillitis, pharyngitis, stomatitis, rheumatoid arthritis, osteoarthritis, low back pain.

A variety of Nimesulide forms are available in the market like in the form of tablets and syrup for oral administration and gels for topical application.

Solubility of Nimesulide in various solvents and solvent-co-solvent mixtures was determined in relation to the development of parenteral formulations.

Nimesulide is soluble in organic solvents like alcohol, DMSO, and dimethyl formamide (DMF).

The quick dissolving tablets of Nimesulide contains superdisintegrants, that accelerates the disintegration of tablets by virtue of their ability to soak up great deal of water once exposed to binary compound surroundings.




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