Comparison of the time to analgesic and anti-inflammatory effect in the treatment of gouty arthritis with Nimesulide and sodium Diclofenac

Objective:

To compare the time to presentation of the analgetic and anti-inflammatory effects of granulated and tablet Nimesulide and sodium Diclofenac since the start of therapy for gouty arthritis (GA).

Methods:

90 males with gout were randomized into 3 equal groups. The patients were of age over 18 years, had acute arthritis for less than 3 weeks, affection of 4 and more joints. For 7 days patients of group 1 received Nimesulide (200 mg/day), those of group 2-Nimesulide(200 mg/day), group 3 - Sodium Diclofenac (150 mg/day). Swelling, articular, pain indices were estimated daily for 7 days.

Results:

Patients of group 1 (Nimesulide) experienced pain relief on min 20; patients of Group 2 (Nimesulide) experienced pain attenuation within the first hour. Pain (at rest and movement) and the indices declined faster in group 1 and 2 compared to group 3. Arthritis was arrested in 24 (80%) patients of group 1, 11 (36%) of group 2 and 4 (13%) of group 3.

Conclusions:

Efficacy of Nimesulide for arrest of an acute gout attack exceeds that of sodium diclofenac.

Effects of Nimesulide Drug were more marked than for celecoxib, with evidence of a faster onset of the analgesic action.

Objective:

One Study was designed to investigate the analgesic effects of nimesulide and celecoxib in patients with knee osteoarthritis (OA).

Methods:

44 Patients, Nimesulide (100 mg twice a day) or Celecoxib (200 mg once a day) for 2 weeks. The intensity of joint pain was assessed with a 100-mm visual analogue scale (VAS).

Results:

Effects of Nimesulide were more marked than for celecoxib, with evidence of a faster onset of the analgesic action.

Both after a single or repeated administration, Nimesulide significantly reduced the synovial fluid concentrations of SP and IL-6. Celecoxib, on the other hand, did not change the concentrations of SP and significantly reduced the levels of IL-6 only on day 14. None of the drugs affected IL-8. Both drugs were generally well tolerated.

Conclisions:

These results provide evidence that Nimesulide Drug is an effective agent for the symptomatic treatment of OA.

Nimesulide and Paracetamol

The efficacy and tolerability of nimesulide 100mg were compared with those of paracetamol in a nonblind randomised study that recruited 110 children (64 males, 46 females; aged 3 to 6 years) with inflammation of the upper respiratory tract and fever. Nimesulide suspension (1.5 mg/kg 3 times daily) or paracetamol syrup (10 mg/kg 4 times daily) were administered orally until fever resolved. Body temperature was recorded and local pain and general discomfort assessed. Three patients treated with nimesulide and 6 patients treated with paracetamol withdrew from the study as a result of adverse events, and 1 paracetamol-treated patient discontinued because of a requirement for therapy with steroids. Nimesulide was as effective as paracetamol in reducing fever, local pain, and general discomfort. Nimesulide therefore appears to be at least as effective as paracetamol in terms of antipyretic and anti-inflammatory activity in children with inflammation of the upper respiratory tract and fever.

Nimesulide Use

Nimesulide Use

Nimesulide 100mg is a non-steroidal anti-inflammatory drug, prescribed for painful inflammatory conditions, back pain, dysmenorrhea, postoperative pain, osteoarthritis, and fever.

Nimesulide 100mg  has superior gastrointestinal safety as compared to other NSAIDs.

Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.

It has proven benefits in the treatment of Acute (short term) pain, Painful osteoarthritis (Swelling in the joints) and Primary dysmennorhea ( Period Pains).

Nimesulide Usage:

Nimesulide must be prescribed by a licensed physician as second line treatment in the approved indications and in compliance with the recommendations expressed in the Summary of Product Characteristics.

Daily dose is 100mg twice-a-day.

The maximum duration of a treatment course is 15 days and, as for other NSAIDs, treatment should be as short as possible. Nimesulide is not indicated in children younger than 12.

Other Precautions : 

 Avoid excess dosage. 

Storage Conditions :

Store it in cool place. 

Nimesulide Solubility

The lipophilicity and solubility profile of nimesulide was investigated over a broad pH range. Lipophilicity was assessed by direct partitioning experiments in the octanol-water system using the shake flask method, as well as by reversed-phase HPLC using methanol as organic modifier with or without addition of n-octanol. In the latter case the extrapolated retention factors logk(w) were considered as lipophilicity indices. The presence of n-octanol in the mobile phase proved to be a crucial factor for the establishment of a logk(w)/pH profile very similar to the logD/pH profile of nimesulide. Solubility was determined by the shake flask method using saturated buffer solutions. Both lipophilicity and solubility--pH profiles of nimesulide showed deviations from the theoretically expected behavior as dictated by the Henderson-Hasselbach equation and the usually recorded difference of 4 log units between the corresponding values of the neutral and ionized species in the case of a weak acid. As a consequence the lipophilicity and solubility profiles were found not to be mirror images of each other. However, the pK(a) value of nimesulide could be accurately calculated using part of both lipophilicity and solubility profiles since deviations affected mostly the values at increased ionization.

Nimesulide Drug

Nimesulide Drug:

Nimesulide Drug is a non-steroidal anti-inflammatory drug, prescribed for painful inflammatory conditions, back pain, dysmenorrhea, postoperative pain, osteoarthritis, and fever.

How it should be taken : It comes as a tablet to take by mouth, with food.

Nimesulide  Adavantages:

Nimesulide has superior gastrointestinal safety as compared to other NSAIDs.Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.It has proven benefits in the treatment of Acute (short term) pain, Painful osteoarthritis (Swelling in the joints) and Primary dysmennorhea ( Period Pains).

Nimesulide  Usage:

Nimesulide drug must be prescribed by a licensed physician as second line treatment in the approved indications and in compliance with the recommendations expressed in the Summary of Product Characteristics.

Daily dose is 100mg twice-a-day.

The maximum duration of a treatment course is 15 days and, as for other NSAIDs, treatment should be as short as possible. Nimesulide is not indicated in children younger than 12.

The overall safety profile of nimesulide is in line with that of all other NSAIDs.

As with all drugs, it must be used in the most appropriate way to guarantee its best therapeutic value.

Other Precautions :  Avoid excess dosage. 

Storage Conditions : Store it in cool place.