Effects of Nimesulide Drug were more marked than for celecoxib, with evidence of a faster onset of the analgesic action.

Objective:

One Study was designed to investigate the analgesic effects of nimesulide and celecoxib in patients with knee osteoarthritis (OA).

Methods:

44 Patients, Nimesulide (100 mg twice a day) or Celecoxib (200 mg once a day) for 2 weeks. The intensity of joint pain was assessed with a 100-mm visual analogue scale (VAS).

Results:

Effects of Nimesulide were more marked than for celecoxib, with evidence of a faster onset of the analgesic action.

Both after a single or repeated administration, Nimesulide significantly reduced the synovial fluid concentrations of SP and IL-6. Celecoxib, on the other hand, did not change the concentrations of SP and significantly reduced the levels of IL-6 only on day 14. None of the drugs affected IL-8. Both drugs were generally well tolerated.

Conclisions:

These results provide evidence that Nimesulide Drug is an effective agent for the symptomatic treatment of OA.