Nimesulide forms

Nimesulide tablet is indicated for the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old with with analgesic and antipyretic properties.

Nimesulide is available in the form of tablets, powder for dissolution in water, suppositories, mouth dissolving tablets and topical gel.

Nimesulide dosage is of 100 mg for the tablets, and100 mg for granules for oral suspension, 200mg for the suppositories and 3% of gel.

The maximum duration prescribed for the tablet is15 days and the dosage to be used is 100mgs.

The use of nimesulide in children under the age of 12 is contraindicated. Continuous use of nimesulide (more than 15 days) can cause the following side effects:

• Diarrhea
• Vomiting
• Skin rash
• Dizziness
• Bitterness in mouth.

 Women should use the drug with caution during lactation and it is contraindicated during pregnancy

Nimesulide 100mg tablet for painrelief

Prescribed painkiller tablet Nimesulide is an Non-steroidal anti-inflammatory drug has superior gastrointestinal safety as compared to other NSAIDs with the rapid onset analgesic action.

NImesulide drug  is used for the treatment of acute pain, Painful osteoarthritis (Swelling in the joints) and primary dysmenorrhoea.

Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.

The maximum duration and dose of a treatment course with nimesulide is recommended with the shortest period of 15 days, 100 mg twice a day, to minimize the risk of hepatotoxicity.

Nimesulide is available in the form of gel, powder, capsules and tablets.

The maximum duration and dose of a treatment course with nimesulide is recommended with the shortest period of 15 days, 100 mg twice a day, to minimize the risk of hepatotoxicity.

Nimesulide should only be prescribed as second line treatment. The decision to prescribe nimesulide should be based on assessment of the individual patient.

Nimesulide also improves the skin tone and to increase in energy levels. Food, gender and advanced age have negligible effects on Nimesulide pharmacokinetics.

 

Nimesulide Solubility (Newest posts first) - MedsChat - The People's Medicine Community

Nimesulide Solubility (Newest posts first) - MedsChat - The People's Medicine Community

Comparison of the time to analgesic and anti-inflammatory effect in the treatment of gouty arthritis with Nimesulide and sodium Diclofenac

Objective:

To compare the time to presentation of the analgetic and anti-inflammatory effects of granulated and tablet Nimesulide and sodium Diclofenac since the start of therapy for gouty arthritis (GA).

Methods:

90 males with gout were randomized into 3 equal groups. The patients were of age over 18 years, had acute arthritis for less than 3 weeks, affection of 4 and more joints. For 7 days patients of group 1 received Nimesulide (200 mg/day), those of group 2-Nimesulide(200 mg/day), group 3 - Sodium Diclofenac (150 mg/day). Swelling, articular, pain indices were estimated daily for 7 days.

Results:

Patients of group 1 (Nimesulide) experienced pain relief on min 20; patients of Group 2 (Nimesulide) experienced pain attenuation within the first hour. Pain (at rest and movement) and the indices declined faster in group 1 and 2 compared to group 3. Arthritis was arrested in 24 (80%) patients of group 1, 11 (36%) of group 2 and 4 (13%) of group 3.

Conclusions:

Efficacy of Nimesulide for arrest of an acute gout attack exceeds that of sodium diclofenac.

Effects of Nimesulide Drug were more marked than for celecoxib, with evidence of a faster onset of the analgesic action.

Objective:

One Study was designed to investigate the analgesic effects of nimesulide and celecoxib in patients with knee osteoarthritis (OA).

Methods:

44 Patients, Nimesulide (100 mg twice a day) or Celecoxib (200 mg once a day) for 2 weeks. The intensity of joint pain was assessed with a 100-mm visual analogue scale (VAS).

Results:

Effects of Nimesulide were more marked than for celecoxib, with evidence of a faster onset of the analgesic action.

Both after a single or repeated administration, Nimesulide significantly reduced the synovial fluid concentrations of SP and IL-6. Celecoxib, on the other hand, did not change the concentrations of SP and significantly reduced the levels of IL-6 only on day 14. None of the drugs affected IL-8. Both drugs were generally well tolerated.

Conclisions:

These results provide evidence that Nimesulide Drug is an effective agent for the symptomatic treatment of OA.

Nimesulide and Paracetamol

The efficacy and tolerability of nimesulide 100mg were compared with those of paracetamol in a nonblind randomised study that recruited 110 children (64 males, 46 females; aged 3 to 6 years) with inflammation of the upper respiratory tract and fever. Nimesulide suspension (1.5 mg/kg 3 times daily) or paracetamol syrup (10 mg/kg 4 times daily) were administered orally until fever resolved. Body temperature was recorded and local pain and general discomfort assessed. Three patients treated with nimesulide and 6 patients treated with paracetamol withdrew from the study as a result of adverse events, and 1 paracetamol-treated patient discontinued because of a requirement for therapy with steroids. Nimesulide was as effective as paracetamol in reducing fever, local pain, and general discomfort. Nimesulide therefore appears to be at least as effective as paracetamol in terms of antipyretic and anti-inflammatory activity in children with inflammation of the upper respiratory tract and fever.