Pharmacodynamic Nimesulide – is an inhibitor of cyclooxygenase so it
inhibits synthesis of destructive prostaglandins and spares
cytoprotective prostaglandins. Nimesulide appears to exert its effects
also through a variety of other mechanisms and involves interference
with the production action of mediators other than prostaglandins such
as enzymes, toxic oxygen derivatives, cytokines, platelet activating
factor and histamine.
Paracetamol – is a valuable central analgesic but weak peripheral anti-inflammatory agent and exhibits agent and exhibits antipyretic action.
Pharmacokinetic Nimesulide – after oral administration the peak plasma concentrations of 1.98-9.85 mg/L are achieved within 1 to 2hrs.
Paracetamol – is rapidly and completely absorbed from gastrointestinal tract. Peak plasma is achieved within 2 to 3hrs
Nimesulide suspension (1.5 mg/kg three times daily) or paracetamol syrup (10 mg/kg four times daily) were administered orally till fever resolved. blood heat was recorded and native pain and general discomfort assessed.
According to the result, Nimesulide was as effective as paracetamol in reducing fever, local pain, and general discomfort. Nimesulide therefore appears to be a minimum of as effective as paracetamol in terms of antipyretic and anti inflammatory activity in children with inflammation of the upper tract and fever.
The other recent study with the patients aged between twelve and sixty years on the premise of analgesic effectiveness and tolerability has well-tried that the analgesic results of Nimesulide had a faster onset (<15 minutes) and was stronger (based on patient opinion). And were well tolerated.
Indications: Sprains, wounds, injury Post surgical plan Dental pain Arthritic Pain pain, fever inflammation accompanying respiratorty track infection and ENT conditions
Paracetamol – is a valuable central analgesic but weak peripheral anti-inflammatory agent and exhibits agent and exhibits antipyretic action.
Pharmacokinetic Nimesulide – after oral administration the peak plasma concentrations of 1.98-9.85 mg/L are achieved within 1 to 2hrs.
Paracetamol – is rapidly and completely absorbed from gastrointestinal tract. Peak plasma is achieved within 2 to 3hrs
Nimesulide suspension (1.5 mg/kg three times daily) or paracetamol syrup (10 mg/kg four times daily) were administered orally till fever resolved. blood heat was recorded and native pain and general discomfort assessed.
According to the result, Nimesulide was as effective as paracetamol in reducing fever, local pain, and general discomfort. Nimesulide therefore appears to be a minimum of as effective as paracetamol in terms of antipyretic and anti inflammatory activity in children with inflammation of the upper tract and fever.
The other recent study with the patients aged between twelve and sixty years on the premise of analgesic effectiveness and tolerability has well-tried that the analgesic results of Nimesulide had a faster onset (<15 minutes) and was stronger (based on patient opinion). And were well tolerated.
Indications: Sprains, wounds, injury Post surgical plan Dental pain Arthritic Pain pain, fever inflammation accompanying respiratorty track infection and ENT conditions
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