Nimesulide gel

Nimesulide Gel

Nimesulide is available in the market in various forms including tablets (100 mg), granules for oral suspension (100 mg), suppositories (200 mg) and gel (3%).

Nimesulide Gel should be applied to the affected area, for 2 to 4 times every day.

Gel is used for the treatment of chronic and acute musculoskeletal disorders including discomfort in the muscles, tendonitis (cord), back pain/ache, arthritis, tenosynovitis(swelling in tendon) sprains, or strains.

Some patients were analysed for assessing the efficacy and safety of this gel. 

This studies results in better relief from pain and inflammation(redness/ swelling in a part of a body) parameters in more number of patients with nimesulide Gel.

Nimesulide exhibited better efficacy, and demonstrated faster onset of action.

 Nimesulide provides significant analgesic (painrelief) activity when applied topically. Peak analgesic effect was observed at 120 min from teatment

It functions by inhibiting particular nerve impulses sent from the periphery to your central system, leading to a decrease of sensitivity from the kinds of symptoms associated with the conditions above.

Nimesulide Efficacy

The efficacy of nimesulide (100mg twice daily) was compared with that of naproxen (500mg twice daily) in 53 adult patients with nonbacterial acute inflammation of the ear, nose or throat in a double-blind phase III clinical investigation. Both drugs were administered orally after meals for a mean duration of 8.7 days.

In this setting, nimesulide was associated with relief of pain and inflammatory signs (exudation and swelling). Indeed, treatment with nimesulide led to clinical improvement superior to that obtained with naproxen in terms of both rapidity of action and improvement of the symptoms at the end of therapy. Nimesulide therapy was also very well tolerated and no patient reported an adverse event. In contrast, 2 naproxen-treated patients reported episodic gastralgia of moderate intensity.

Nimesulide's therapeutic value in effectively and rapidly controlling inflammation and pain is supported by significant clinical evidence.

Clinical studies have been carried out in a wide variety of acute inflammatory and painful conditions with the aim of evaluating the analgesic activity of nimesulide in comparison to placebo and to some of the most common NSAIDs.

In these studies, the efficacy of nimesulide was consistently superior to placebo and at least comparable, or in some cases superior, to that observed for the reference drugs, with a particularly fast onset of the analgesic action.

Nimesulide posses analgesic properties with multifactorial mode of action for the treatment of musculoskeletal system, dysmenorrhoea, and acute pain.
The abilities of NSAID’s drug nimesulide to inhibit COX-2 preferentially and to exert other novel anti-inflammatory actions are consistent with good efficacy and safety with highly effective in reducing pain, inflammation and also helps in better penetration of the antibiotics.

It also undergoes extensive biotransformation. The recent study on the basis of analgesic activity of Nimesulide has proved that it has a quicker onset which shows relief from pain relief and inflammation within 15 minutes from drug intake.

Nimesulide is recommended for the shortest duration necessary to control symptoms in patients with acute pain or primary dysmenorrhoea.

Nimesulide gel

Nimesulide is available in various forms including tablets, suppositories, water-soluble powders, and topical gels.

Original Nimesulide is commercially available as tablets (100 mg), granules for oral suspension (100 mg), suppositories (200 mg) and gel (3%).

Nimesulide gel possesses higher anti-inflammatory activity compared to other gel’s.

Dosage and Administration

Nimesulide Gel is apply to the affected area, rubbing in a thin layer of the gel 2 to 4 times every day. For best results, wash the application area beforehand to clean away any oil, grease, or bacteria, allowing the gel to absorb more easily.

Nimesulide is available in assortment of structures like as tablets and syrup for oral organization and gels for topical application.

The anti-inflammatory activity of topically applied Nimesulide gel demonstrations particularly on cyclo-oxygenase-2 which applies less gastrointestinal antagonistic impacts than different NSAIDs.

The superior analgesic activity of Nimesulide transdermal gel has reported good results in terms of decreasing pain and improved functions in musculoskeletal conditions after topical application.