Nimesulide Solubility

Nimesulide is a preferential COX-2 inhibitor most commonly prescribed for the treatment of various inflammatory conditions such as tonsillitis, pharyngitis, stomatitis, rheumatoid arthritis, osteoarthritis, low back pain.

It has high anti-inflammatory, antipyretic. Solubility of Nimesulide was studied using different cosolvent mixtures and various classes of non-ionic surfactant.

Solubility Increased on solubilization of drug in semi-polar solvents and non-ionic surfactants. Solubility increased drastically (>70 mg/rnl) when polyethylene glycol 300 and polyethylene glycol 400 were used as solvents.

The quick dissolving tablets of Nimesulide contains superdisintegrants, that accelerates the disintegration of tablets by virtue of their ability to soak up great deal of water once exposed to binary compound surroundings.

Solubility of Nimesulide in Organic Solvents

NSAID drug Nimesulide has proven benefits in the treatment of Acute (short term) pain, Painful osteoarthritis (Swelling in the joints) and Primary dysmennorhea (Period Pains).

Nimesulide is available in various forms like Nimesulide Tablets, Nimesulide Powder, Nimesulide Gel, suppositories etc.

Nimesulide is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF).

Nimesulide is an effective and safe therapeutic choice for the treatment of various painful inflammatory conditions, with a rapid onset of analgesic activity.

The prescription of a drug is appropriate when the benefit it is able to provide to a specific patient outweigh the risks associated with its use. A careful evaluation of individual risk factors is therefore of crucial importance.

As for other NSAIDs the use of Nimesulide is recommended for the shortest duration necessary to control symptoms in patients with acute pain or primary dysmenorrhoea.