Nimesulide is a preferential COX-2 inhibitor most commonly prescribed
for the treatment of various inflammatory conditions such as
tonsillitis, pharyngitis, stomatitis, rheumatoid arthritis,
osteoarthritis, low back pain.
It has high anti-inflammatory, antipyretic. Solubility of Nimesulide was studied using different cosolvent mixtures and various classes of non-ionic surfactant.
Solubility Increased on solubilization of drug in semi-polar solvents and non-ionic surfactants. Solubility increased drastically (>70 mg/rnl) when polyethylene glycol 300 and polyethylene glycol 400 were used as solvents.
The quick dissolving tablets of Nimesulide contains superdisintegrants, that accelerates the disintegration of tablets by virtue of their ability to soak up great deal of water once exposed to binary compound surroundings.
It has high anti-inflammatory, antipyretic. Solubility of Nimesulide was studied using different cosolvent mixtures and various classes of non-ionic surfactant.
Solubility Increased on solubilization of drug in semi-polar solvents and non-ionic surfactants. Solubility increased drastically (>70 mg/rnl) when polyethylene glycol 300 and polyethylene glycol 400 were used as solvents.
The quick dissolving tablets of Nimesulide contains superdisintegrants, that accelerates the disintegration of tablets by virtue of their ability to soak up great deal of water once exposed to binary compound surroundings.
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