Nimesulide is a COX-2 selective drug which has the properties of antiinflammatory and antihistaminic, it also possesses analgesic properties.
Apart for the treatment of acute pain, osteoarthritis and primary dysmenorrhoea. Nimesulide is also being widely used for anticancer and antiviral agents.
A variety of new nimesulide derivatives were synthesized through incorporation of a 5-LOX pharmacophore into Nimesulide followed with some structural modifications. which were then characterized for dual enzyme inhibitors for these two types of enzymes (Cyclooxygenase-½ (COX-½) and 5-lipoxygenase (5-LOX) )
Nimesulide is available in various forms like powder/granules, gel, and suppositories.
Clinically it has proven that it supports a particularly good profile in terms of gastrointestinal tolerability.
Its main purpose is to treat acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea.
As for other NSAIDs the use of Nimesulide preffered for the shortest duration necessary to control symptoms in patients with acute pain or primary dysmenorrhoea. The efficacy of Nimesulide was consistently superior to placebo with its particularly rapid onset action.
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