Nimesulide
Solubility
NSAID drug
NImesulide has
proven benefits in the treatment of Acute (short term) pain, Painful
osteoarthritis (Swelling in the joints) and Primary dysmennorhea
(Period Pains).
Nimesulide is
available in various forms like Nimesulide Tablets, Nimesulide
Powder, Nimesulide Gell, suppositories
etc.
Nimesulide
is soluble in organic solvents such as ethanol, DMSO, and dimethyl
formamide (DMF).
nimesulide
is an effective and safe therapeutic choice for the treatment of
various painful inflammatory conditions, with a rapid onset of
analgesic activity.
As
for other NSAIDs the use of nimesulide is recommended for the
shortest duration necessary to control symptoms in patients with
acute pain or primary dysmenorrhoea.
Solubility of Nimesulide was studied using different cosolvent mixtures and various classes of non-ionic surfactant. Solubility increased drastically (>70 mg/rnl) when polyethylene glycol 300 and polyethylene glycol 400 were used as solvents.
The quick dissolving tablets of Nimesulide contains superdisintegrants, that accelerates the disintegration of tablets by virtue of their ability to soak up great deal of water once exposed to binary compound surroundings.
No comments:
Post a Comment