Nimesulide Uses and actions

Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) which acts as a cyclooxygenase- 2 inhibitor. Which has become a leading NSAID in over 50 countries worldwide for the treatment of post-traumatic inflammation, acute musculoskeletal disorders including sprains, strains, tendinitis, tenosynovitis, low back pain, periarthritis (shoulder pain) and osteoarthritis (joint pains), stiffness.
Nimesulide is a multi-factorial drug in controlling inflammation and pain. The adverse reaction profile of nimesulide is, in general, like that of other NSAIDs.As for other NSAIDs the use of Nimesulide is preffered for the shortest duration necessary to control symptoms in patients with acute pain or primary dysmenorrhoea. 

Nimesulide is available in the form of gel, powder, capsules and tablets.

Nimesulide also improves the skin tone and to increase in energy levels. Food, gender and advanced age have negligible effects on Nimesulide pharmacokinetics

Nimesulide dose

Nimesulide medication is a non-steroidal anti-inflammatory drug, prescribed for painful inflammatory conditions, back pain, dysmenorrhea, postoperative pain, osteoarthritis, and fever.

Nimesulide Dosage:

• Adults: 100 mg twice daily
• Children: 5mg/kg of body weight in 2 or 3 divided doses.

The minimum effective dose should be used for the shortest duration to reduce the undesirable effects.

The maximum duration of a treatment course with Nimesulide is 15 days.

Nimesulide 100mg Tablets/granules should be used for the shortest possible duration, as required by the clinical situation.

Adults:
100mg bid after mealElderly:

In elderly patients there is no need to reduce the daily dosage

Children (< 12 years):
Nimesulide 100mg Tablets/granules is contraindicated in these patients.

Adolescents (from 12 to 18 years):
on the basis of the kinetic profile in adults and on the pharmacodynamic characteristics of nimesulide, no dosage adjustment in these patients is necessary.

Nimesulide Pain relief

Nimesulide was developed by Helsinn Healthcare and is marketed world-wide around 50 countries.It is used for the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoeaIt has multifactorial mode of action and is characterized by a fast onset of analgesic action.

The rapid onset of analgesic action gives meaningful reductions in pain and inflammation within 15 minutes from drug intake.

It is available in a variety of forms: tablets, powder for dissolution in water, suppositories, mouth dissolving tablets and topical gel.Anti-inflammatoryAnalgesics tablet – Nimesulide is very much required for the quick treatment of severe muscular pains and inflammatory problems.

It has superior gastrointestinal safety as compared to other NSAIDs.

nimesulide for fever

Nimesulide is a non-steroidal anti-inflammatory (NSAID) drug which has been found to be useful in the treatment of fever.Clinical studies of Nimesulide in treating children with fever have been carried out. In the children receiving Nimesulide, it took 8.6h to reach normal temperature.  The mean decrease in temperature for each cycle was slightly higher for the Nimesulide group. The drugs were well tolerated by the children.Nonsteroidal anti-inflammatory drugs (NSAIDs) are the mainstay of treatment in pain. Various fixed dose combinations of NSAIDs are available in the market, particularly those of paracetamol and ibuprofen.

Nimesulide tablet dose

Nimesulide medication is a non-steroidal anti-inflammatory drug, prescribed for painful inflammatory conditions, back pain, dysmenorrhea, postoperative pain, osteoarthritis, and fever.Nimesulide Dosage:

Adults: 100 mg twice daily
Children: 5mg/kg of body weight in 2 or 3 divided doses.Nimesulide 100mg Tablets/granules should be used for the shortest possible duration, as required by the clinical situation.

Adults:
100mg bid after meal.

Elderly:
In elderly patients there is no need to reduce the daily dosageThe best prescribed Nimesulide tablet is used for the treatment of acute pain, Primary dysmennorhea and also to treat degenerative joint disease.Forms: A variety of Nimesulide forms are available in the market like in the form of tablets and syrup for oral administration and gels for topical application.Dose: Nimesulide is available with the dosage of 100 mg for tablets, 100 mg for granules for oral suspension, 200mg for suppositories and 3% of gel.Nimesulide tablets exerts less gastrointestinal adverse effects than other NSAIDs. It is available in different brands in worldwide among 50 countries.Nimesulide is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF).Nimesulide transdermal gel is a well tolerated novel hydroalcoholic microcarrier based drug delivery system with penetration enhancer, indicated for a variety of conditions characterized by pain, inflammation and stiffness, such as osteoarthritis, periarthritis, post-traumatic or acute musculoskeletal disorders including tendinitis, tenosynovitis, sprains, strains and low back pain.Solubility of Nimesulide was studied using different cosolvent mixtures and various classes of non-ionic surfactant. Solubility increased drastically (>70 mg/rnl) when polyethylene glycol 300 and polyethylene glycol 400 were used as solvents.The quick dissolving tablets of Nimesulide contains superdisintegrants, that accelerates the disintegration of tablets by virtue of their ability to soak up great deal of water once exposed to binary compound surroundings.

Nimesulide Chemical Structure

Nimesulide is generally utilized as a part of the treatment of inflammatory torment which hinders the protein cyclooxygenase-2 (COX-2) and has better gastro-intestinal mediocrity in addition to different NSAIDs in its class.

Molecular formula of Nimesulide is C13H12N2O5S

Nimesulide (4-nitro-2-phenoxymethanesulfoanilide) may be a selective Cox-2 anti-inflammatory drug.

This compound, a by-product of p-nitrophenyl methane series sulfa, is structurally a singular non-steroidal anti-inflammatorydrug. It belongs to selective COX-2inhibitors, with a potent analgesic activity.

It is available in more than 50 countries worldwide.

Features:

• Amongst most effective yet gastro friendly
• Non steroidal anti inflammatory drug (NSAID)
• Nimesulide targets COX-2 an enzyme responsible for inflammation & pain.

Nimesulide tablet incorporates:

• Fast results
• Helpful and supportive
• No feature impacts
• Fast and quick effects

Nimesulide Painkiller Tablet

Nimesulide is used in giving relief from acute pain associated with rheumatoid arthritis, osteoarthritis and primary dysmenorrhoea in adolescents and adults.

The drug is also an effective antipyretic and used to treat headaches and flu. It is also used in treating inflammatory conditions in humans and pain caused by arthritis or severe injury.

Nimesulide is a popular NSAID and available in various forms including tablets, suppositories, water-soluble powders, and topical gels.

Working of Nimesulide:

It acts by inhibiting the release of tumour necrosis factor-alpha, acts as a competitive inhibitor of histamine release and reduces superoxide anion formation

Nimesulide Dosage:

Adults: 100 mg twice daily
Children: 5mg/kg of body weight in 2 or 3 divided doses.

The minimum effective dose should be used for the shortest duration to reduce the undesirable effects.

The maximum duration of a treatment course with Nimesulide is 15 days.