Nimesulide tablet dose

The main purpose of Nimesulide tablets is for the treatment of painful inflammatory conditions, back pain, dysmenorrhea, postoperative pain, osteoarthritis, and fever.

Oral dosage form in adults :100 mg and In children : 5 mg/kg/day in 2 or 3 divided doses. It is prescribed for the shortest duration.

Nimesulide has superior gastrointestinal safety as compared to other NSAIDs. Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.

Nimesulide tablet prevents cancer by inhibiting the proliferation of various types of cancer cells mainly via COX-2 independent mechanisms. It is also used for dry skin, to improve skin-tone,and to increase energy.

Nimesulide treatment  also brought about an immediate and significant improvement in over-all pain, exudation, oedema and headache.

Nimesulide Formulation and features

Nimesulide, a wide endorsed medicine pain relieving drug fits in with BCS classification II and show low and variable oral bioavailability.

Nimesulide (4-nitro-2-phenoxymethanesulfoanilide) may be a particular Cox-2 anti-inflammatory medication. This compund, a by-result of p-nitrophenyl methane arrangement sulfa, is structurally a solitary non-steroidal anti-inflammatorydrug. It has a place with particular COX-2inhibitors, with an intense pain relieving movement.

its shown as second line treatment for  acute pain, symptomatic treatment of excruciating degenerative joint ailment and first dysmenorrhoea.

It's conjointly utilized for the treatment of skin-tone, Heart illnesses and dry skin.

Nimesulide tablet features incorporate :

• Fast results
• Helpful and supportive
• No feature impacts
• Fast and quick effects

Use of Nimesulide 100mg- pill :

• Pain relieving and antipyretic.
• Rheumatic inflammatory sickness, degenerative joint ailment, elective perpetual joint issue treatment
• Musculo skeletal issue treatment
• Thrombophlebitis.
• Enhances skintone
• Heart Diseases
• Dry Skin
• Malignancy treatment

Nimesulide Medicine for Joint pain treatment

Joint ache influenced by osteoarthritis (OA) which is a gathering of mechanical abnormailities including debasement of joints, and NSAID’s – Nimesulide is most regularly used to treat agony connected with OA.

The primary symptom is agony, creating loss of capacity and regularly solidness. Osteoarthritis (OA) is brought about by aging joints, damage, and obesity. OA usually influences the hands, feet, spine, and the expansive weight bearing joints, for example, the hips and knees.


Nimesulide proved to be significantly more viable in giving symptomatic relief. Nimesulide speaks to a successful operator for the treatment of joint ache, with specific reference to the quick onset of its pain relieving impact.

It additionally utilized for the treatment of primary Dysmenorrhea, and Acute ache.

Nimesulide shows significant diminishments in pain and irritation observed in 15 minutes with pain relieving and antipyretic properties.

Nimesulide Drug Composition

Nimesulide, a wide proposed drug pain relieving medication has a place with sulfonanilide class II and show low and variable oral bioavailability. Nimesulide tablets is generally utilized in inflammatory pain.

Nimesulide (4-nitro-2-phenoxymethanesulfoanilide) is a particular Cox-2 calming medication. This intensify, a by-result of p-nitrophenyl methane arrangement sulfa, is structurally a particular non-steroidal mitigating medication.

It groups antihistaminic, pain relieving and antipyretic properties.

Nimesulide tablet experiences extensive biotransformation and has a generally fast onset of activity, with significant diminishments in agony and irritation saw inside 15 minutes from medication consumption.

Nimesulide is likewise being broadly utilized for anticancer and antiviral operators, and dental surgery.

Nimesulide Synthesis

Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties which, preferentially inhibits the enzyme cyclooxygenase-2 (COX-2)

It has better gastro-intestinal tolerability among other NSAIDs in its class. Its approved indications are the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea, sports injuries etc.

A variety of new nimesulide derivatives were synthesized through incorporation of a 5-LOX pharmacophore into Nimesulide followed with some structural modifications. which were then characterized for dual enzyme inhibitors for these two types of enzymes (Cyclooxygenase-½ (COX-½) and 5-lipoxygenase (5-LOX) )

Clinically it has proven that it supports a particularly good profile in terms of gastrointestinal tolerability.

Nimesulide Gel

Nimesulide tablets is available in gel formulation and applied mainly for topical pain management.

Nimesulide transdermal gel is a well tolerated novel hydroalcoholic microcarrier based drug delivery system with penetration enhancer. This is cause of superior efficacy of Nimesulide Transdermal Gel.

 

Nimesulide gel is indicated for a variety of conditions characterized by pain, inflammation and stiffness, such as osteoarthritis, periarthritis, post-traumatic or acute musculoskeletal disorders including tendinitis, tenosynovitis, sprains, strains and low back pain. It Functions by inhibiting particular nerve impulses sent from the periphery to your central system.

 

Nimesulide is a non-steroidal anti-inflammatory (NSAID) agent which also possess analgesic properties. The product has been formulated using a novel combination of solvents for solubilization of Nimesulide.

 

Nimesulide exhibited better efficacy it also demonstrated faster onset of action. Significant concentration of Nimesulide could be detected in the blood within 30 minutes of treatment and persisted for 8 hours post treatment

Nimesulide Tablets and it's various Forms

The best prescribed Nimesulide tablet is used for the treatment of acute pain, Primary dysmennorhea and also to treat degenerative joint disease.

Apart from tablet the drug- Nimesulide is also available in various forms such as in the form of Gell, powder, and suppositories with the dosage of 100 mg for tablets, 100 mg for granules for oral suspension, 200mg for suppositories and 3% of gel.

Nimesulide is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF).

Nimesulide transdermal gel is a well tolerated novel hydroalcoholic microcarrier based drug delivery system with penetration enhancer.

 

Nimesulide gel is indicated for a variety of conditions characterized by pain, inflammation and stiffness, such as osteoarthritis, periarthritis, post-traumatic or acute musculoskeletal disorders including tendinitis, tenosynovitis, sprains, strains and low back pain.
It’s also available in various brand names of Sulide, Nimalox, Nimesil, Nimulid, Nicip, Nimcap, Nise, Sulidene and Zolan e.t.c. which is available in more than 50 countries world wide.