Nimesulide Medicine

Nimesulide 100mg Therapeutic indications:

• Treatment of acute pain
• Symptomatic treatment of painful osteoarthritis
• Primary dysmenorrhoea.

Nimesulide Medicine uses:

• Nimesulide has less gastrointestinal adverse effects than other NSAIDs
• It has superior benefit-risk ratio to other drugs with a comparable safety and tolerability to placebo.
• Its multifactorial mode of action gives it a unique and broad action on inflammatory.
• Nimesulide is also safe in sensitive asthmatic patients. It is reported to be beneficial in relieving the symptoms of rhinitis, rhinopharyngitis tubaritis and seceretory otitis media with concomitant antibiotic treatment.
• Nimesulide has potent analgesic, anti-inflammatory and antipyretic activities

Nimesulide medicines are recommended for short duration of 15days

Nimesulide Tablet Indication

Anti-inflammatory Analgesics tablet – Nimesulide is required for the quick treatment of severe muscular pains and inflammatory problems. Nimesulide tablets is available in different countries in the world.

Nimesulide is Indicated in reducing pain, fever and inflammatory symptoms of:

• Chronic arthritis
• Osteo arthritis
• Otorhinolary diseases
• Soft tissues and oral cavity inflammation
• Dysmenorrhoea
• Thrombosis
• Urogenital disease
• Postoperative pain states
• Sports injuries

Uses of Nimesulide:

• Rapid onset of action within 15 minutes
• Rapidly relieves pain in arthritis

Precautions:

Women should use the drug with caution during lactation; Nimesulide is contraindicated during pregnancy.
The usual dosage of Nimesulide is 100mg twice a day. For children it should be taken 5mg/kg of body weight in 2 or 3 divided doses

Nimesulide Brands in India

NSAID’s tablet Nimesulide is a widely prescribed anti-inflammatory analgesic drug belongs to BCS class II which is required for the quick treatment of severe muscular pains and inflammatory problems.

NSAID’s tablet Nimesulide is been available since 1985 and sanction with assorted trade names in worldwide in abundance of 50 countries.

Nimesulide is distributed world-wide through a network of selected international partners.

Different trademarks of Nimesulide are:

For Oral Use: Sulide, Nimalox, Nimesil, Nimulid, Nicip (India),, Nimcap, Nise, Sulidene and Zolan, Pain Lock(VIP Pharma India ), Nilden (Mexico),

Why Nimesulide Drugs are Used?

The main purpose of using Nimesulide are:

• To treat acute pain
• To treat osteoarthritis
• To treat primary dysmenorrhoea in adolescents and adults above 12 years old.

Nimesulide tablet incorporates:

• Fast results
• Helpful and supportive
• No feature impacts
• Fast and quick effects

Nimesulide Solubility

Nimesulide is a unique non- steroidal anti-inflammatory drug that acts specifically on cyclo-oxygenase-2 and does not affect cyclo-oxygenase-1. Hence, it exerts its anti-inflammatory action characteristics of non- steroidal anti-inflammatory drug. Solubility of Nimesulide Increased on solubilization of drug in semi-polar solvents and non-ionic surfactants.

Solubility of Nimesulide was studied using different cosolvent mixtures and various classes of non-ionic surfactant. Solubility increased drastically (>70 mg/rnl) when polyethylene glycol 300 and polyethylene glycol 400 were used as solvents.

The quick dissolving tablets of Nimesulide contains superdisintegrants, that accelerates the disintegration of tablets by virtue of their ability to soak up great deal of water once exposed to binary compound surroundings.

Nimesulide is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, Nimesulide should first be dissolved in ethanol and then diluted with the aqueous buffer of choice. Nimesulide has a solubility of approximately <200 μg/ml in a 10% DMSO in PBS (pH 7.2) solution using this method.

Nimesulide Tablets Use

Nimesulide is a popular NSAID prescribed for painful inflammatory conditions, back pain, dysmenorrhea associated with musculoskeletal system, Thrombophlebitis, dental pain and in ENT inflammation. 

Nimesulide is a prescription drug with important analgesic properties. Therefore it is always recommended to use this medicine under a licensed physician supervision and as per approved indications.

Nimesulide is available in various forms including tablets, suppositories, water-soluble powders, and topical gels. It is an analgesic and antipyretic in action.

Nimesulide Drug uses: 

• Nimesulide has less gastrointestinal adverse effects than other NSAIDs.
• It has superior benefit-risk ratio to other drugs with a comparable safety and tolerability to placebo.
• Rapid onset of action within 15 minutes
• Rapidly relieves pain in arthritis
• Its multifactorial mode of action gives it a unique and broad action on inflammatory.
• Nimesulide is also safe in sensitive asthmatic patients.
• It is reported to be beneficial in relieving the symptoms of rhinitis, rhinopharyngitis tubaritis and seceretory otitis media with concomitant antibiotic treatment.
• Nimesulide has potent analgesic, anti-inflammatory and antipyretic activities.

Nimesulide Tablet Uses

Nimesulide medication is a non-steroidal anti-inflammatory drug with analgesic and antyperetic properties, prescribed for painful inflammatory conditions, back pain, dysmenorrhea and etc.

The usual dosage of Nimesulide is 100mg twice a day. For children it should be taken 5mg/kg of body weight in 2 or 3 divided doses

Nimesulide is used to reduce:

1. Osteoarthritis
2. Low back Pain
3. Sports injury
4. Dental pain
5. Moderate pain & fever
6. Dysmenorrhea

Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.

Nimesulide is reported to be beneficial in relieving the symptoms of rhinitis, rhinopharyngitis tubaritis and seceretory otitis media with concomitant antibiotic treatment.

Precautions:

Women should use the drug with caution during lactation; Nimesulide is contraindicated during pregnancy.

Nimesulide Drug

Pharmacokinetic: Nimesulide has a potent Anti-Inflammatory action.It behaves as a competetive inhibitor of histamine release in-vivo and in-vitro, hence posseses antihistaminic and antiallergic properties.

Indications:
Nimesulide is indicated in painful inflammatory conditions associated with musculoskeletal system, dysmenorrhoea, Thrombophlebitis, dental pain and in ENT inflammation. Absorption Well absorbed from GI tract following oral admin. Peak plasma levels:1-3 hours. With bid admin of 100 mg, steady-state is achieved within 24-36 hours.

Routes of Administration and Dosage: Oral dosage form in adults :100 mg b.i.d In children : 5 mg/kg/day in 2 or 3 divided doses.

Nimesulide Drug uses: 

• Nimesulide has less gastrointestinal adverse effects than other NSAIDs.
• It has superior benefit-risk ratio to other drugs with a comparable safety and tolerability to placebo.
• Its multifactorial mode of action gives it a unique and broad action on inflammatory.
• Nimesulide is also safe in sensitive asthmatic patients.
• It is reported to be beneficial in relieving the symptoms of rhinitis, rhinopharyngitis tubaritis and seceretory otitis media with concomitant antibiotic treatment.
• Nimesulide has potent analgesic, anti-inflammatory and antipyretic activities.