Nimesulide Tablet Formulation

Nimesulide, a widely prescribed anti-inflammatory analgesic drug belongs to BCS class II and exhibit low and variable oral bioavailability.

 

Nimesulide (4-nitro-2-phenoxymethanesulfoanilide) may be a particular Cox-2 anti-inflammatory medication. This compund, a by-result of p-nitrophenyl methane arrangement sulfa, is structurally a solitary non-steroidal anti-inflammatorydrug. It has a place with particular COX-2inhibitors, with an intense pain relieving movement.

its shown as second line treatment for  acute pain, symptomatic treatment of excruciating degenerative joint ailment and first dysmenorrhoea.

Nimesulide tablet incorporates:

• Fast results
• Helpful and supportive
• No feature impacts
• Fast and quick effects

Nimesulide Tablet Advantages:

• Nimesulide has less gastrointestinal adverse effects than other NSAIDs
• It has superior benefit-risk ratio to other drugs with a comparable safety and tolerability to placebo.
• Its multifactorial mode of action gives it a unique and broad action on inflammatory.
• Nimesulide is also safe in sensitive asthmatic patients. It is reported to be beneficial in relieving the symptoms of rhinitis, rhinopharyngitis tubaritis and seceretory otitis media with concomitant antibiotic treatment. 
• Nimesulide has potent analgesic, anti-inflammatory and antipyretic activities

Nimesulide Tablet Composition

Nimesulide is a Non steroidal anti inflammatory drug (NSAID) and targets COX-2 an enzyme responsible for inflammation & pain.

Nimesulide is used in the treatment of Osteoarthritis, Low back Pain, Sports injury, Dental pain, Moderate pain & fever, and Dysmenorrhea.

Uses of Nimesulide:

• Rapid onset of action within 15 minutes
• Rapidly relieves pain in arthritis

The nimesulide is preferably used in the composition in an amount of 0.1-5% by weight, more preferably in an amount of 0.1-3% by weight, most preferably in an amount of around 1 % by weight of the composition.

This medication is for the most part used as an issue of the treatment of inflammatory torment and also used for postoperative trauma, sports injuries, acute musculoskeletal disorders

Nimesulide Drug Uses

Pharmacokinetic:

Nimesulide has a potent Anti-Inflammatory action.It behaves as a competetive inhibitor of histamine release in-vivo and in-vitro, hence posseses antihistaminic and antiallergic properties.

Indications:

Nimesulide is indicated in painful inflammatory conditions associated with musculoskeletal system, dysmenorrhoea, Thrombophlebitis, dental pain and in ENT inflammation.

Absorption:

Well absorbed from GI tract following oral admin. Peak plasma levels:1-3 hours. With bid admin of 100 mg, steady-state is achieved within 24-36 hours.


Routes of Administration and Dosage:

Oral dosage form in adults :100 mg b.i.d In children : 5 mg/kg/day in 2 or 3 divided doses.

Nimesulide Drug uses:

• Nimesulide has less gastrointestinal adverse effects than other NSAIDs
• It has superior benefit-risk ratio to other drugs with a comparable safety and tolerability to placebo.
• Its multifactorial mode of action gives it a unique and broad action on inflammatory.
• Nimesulide is also safe in sensitive asthmatic patients. It is reported to be beneficial in relieving the symptoms of rhinitis, rhinopharyngitis tubaritis and seceretory otitis media with concomitant antibiotic treatment.
• Nimesulide has potent analgesic, anti-inflammatory and antipyretic activities

Nimesulide Efficacy

The abilities of NSAID’s drug nimesulide to inhibit COX-2 preferentially and to exert other novel anti-inflammatory actions are consistent with good efficacy and safety with highly effective in reducing pain, inflammation and also helps in better penetration of the antibiotics.

Nimesulide posses analgesic properties with multifactorial mode of action for the treatment of musculoskeletal system, dysmenorrhoea, and acute pain .

It also undergoes extensive biotransformation. The recent study on the basis of analgesic activity of nimesulide has proved that Nimesulide had a quicker onset which shows relief from pain relief and inflammation within 15 minutes from drug intake.

Nimesulide is recommended for the shortest duration necessary to control symptoms in patients with acute pain or primary dysmenorrhoea.

Nimesulide 100mg Uses

Nimesulide 100mg Therapeutic indications:

• Treatment of acute pain
• Symptomatic treatment of painful osteoarthritis
• Primary dysmenorrhoea.

Nimesulide 100mg Tablets/granules should be used for the shortest possible duration, as required by the clinical situation.

Adults:

100mg bid after meal.

Elderly:

In elderly patients there is no need to reduce the daily dosage.

Children (< 12 years):

Nimesulide 100mg Tablets/granules is contraindicated in these patients.

Adolescents (from 12 to 18 years):

on the basis of the kinetic profile in adults and on the

pharmacodynamic characteristics of nimesulide, no dosage adjustment in these patients is necessary.

 

Nimesulide 100mg Uses:

• Analgesic and antipyretic.
• Rheumatoid arthritis, osteoarthritis, other degenerative joint disorders.
• Musculo skeletal disorders.
• Thrombophlebitis.

Nimesulide Dose

The main purpose of Nimesulide tablets is for the treatment of painful inflammatory conditions, back pain, dysmenorrhea, postoperative pain, osteoarthritis, and fever.

Oral dosage form prescribed for the shortest duration

In adults:100 mg
In children: 5 mg/kg/day in 2 or 3 divided doses.

Nimesulide has superior gastrointestinal safety as compared to other NSAIDs. Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.

Nimesulide tablet prevents cancer by inhibiting the proliferation of various types of cancer cells mainly via COX-2 independent mechanisms. It is also used for dry skin, to improve skin-tone,and to increase energy.

Nimesulide treatment  also brought about an immediate and significant improvement in over-all pain, exudation, oedema and headache.

Nimesulide Solubility

Nimesulide is a preferential COX-2 inhibitor most commonly prescribed for the treatment of various inflammatory conditions such as tonsillitis, pharyngitis, stomatitis, rheumatoid arthritis, osteoarthritis, low back pain.

It has high anti-inflammatory, antipyretic. Solubility of Nimesulide was studied using different cosolvent mixtures and various classes of non-ionic surfactant.

Solubility Increased on solubilization of drug in semi-polar solvents and non-ionic surfactants. Solubility increased drastically (>70 mg/rnl) when polyethylene glycol 300 and polyethylene glycol 400 were used as solvents.

The quick dissolving tablets of Nimesulide contains superdisintegrants, that accelerates the disintegration of tablets by virtue of their ability to soak up great deal of water once exposed to binary compound surroundings.