Nimesulide is a non-steroidal anti-inflammatory (NSAID) drug which has been found to be useful in the treatment of fever.Clinical studies of Nimesulide in treating children with fever have been carried out. In the children receiving Nimesulide, it took 8.6h to reach normal temperature. The mean decrease in temperature for each cycle was slightly higher for the Nimesulide group. The drugs were well tolerated by the children.Nonsteroidal anti-inflammatory drugs (NSAIDs) are the mainstay of treatment in pain. Various fixed dose combinations of NSAIDs are available in the market, particularly those of paracetamol and ibuprofen.
No side effects were reported in any child. The result showed that Nimesulide acted more rapidly in bringing down the temperature to normal.
Nimesulide appears to exert its effects also through a variety of other mechanisms and involves interference with the production action of mediators other than prostaglandins such as enzymes, toxic oxygen derivatives, cytokines, platelet activating factor and histamine.
The anti-inflammatory activity of topically applied Nimesulide gel commonly used in the management of Musculoskeletal injuries.
Nimesulide gel possesses higher anti-inflammatory activity compared to other gel’s.
The superior analgesic activity of Nimesulide transdermal gel has reported good results in terms of decreasing pain and improved functions in musculoskeletal conditions after topical application.
Nimesulide transdermal gel is a novel hydroalcoholic microcarrier based drug delivery system with penetration enhancer.
Treatment:
Nimesulide gel is demonstrated for an assortment of conditions depicted by anguish, irritation and strength, for instance, osteoarthritis, periarthritis, post-traumatic or extreme musculoskeletal issue including tendinitis, tenosynovitis, sprains, strains and low back torment. It Functions via limiting particular nerve inspirations sent from the edge to your central system.
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